CoVAB Principal Prof. Frank Norbert Mwiine (R) , Deputy Principal Prof. James Okwee Acai (C) and Prof. Lawrence Mugisha present the best BVM students for the award during the Third Session of Makerere University's 72nd Graduation Ceremony on 25th May 2022.
BALINANDI Karabyo Stephen Ticks and tick-borne diseases of cattle in selected districts of Uganda: zoonotic potential and public health implications
Dr. BALINANDI Karabyo Stephen investigated the diversity of ticks infesting cattle, and their importance for public health attention in Uganda. This is because ticks are now increasingly recognized as a major factor in the epidemiology of various zoonotic diseases. The field work was done in the districts of Kasese, Hoima, Gulu, Soroti and Moroto, between September and November 2017. In total, 4,362 ticks were collected from 500 cattle, from which 15 tick species were found. Prior to this study, the economically important tick species, Rhipicephalus microplus, that spreads fatal babesiosis in cattle, was only found in Serere district. With the work herein published, Rhipicephalus microplus has been found also in Gulu and Soroti districts. This study also identified several viruses that were circulating in Ugandan cattle, including 4 potential novel viruses. In addition, it was revealed from this study that Crimean-Congo hemorrhagic fever, one of the most important tickborne infections for humans around the world, was widely spread in Uganda. Overall, this study highlighted the need for increased surveillance of tickborne diseases in Uganda, and for government policy to focus on control of ticks as an important vector of human diseases. The study was funded by the Swedish Research Council and supervised by Assoc Prof Lawrence Mugisha, Assoc Prof Maja Malmberg and Dr. Julius J. Lutwama.
Ms. NAMAYANJA Monica studied how Trypanosoma brucei brucei, interacts with host cells when crossing different biological barriers. First, a mouse model was employed to seek whether crossing of the blood-brain barrier commences at the same time for different strains. Further, in vitro models, confocal and scanning electron microscopy were used to determine the crossing mechanism. Subsequently, a protein previously suspected to be involved in blood brain barrier traversal was localized. Findings showed that different strains cross the blood brain barrier at different time points, that crossing of different biological barriers is different, and modification of the host plasma membrane was observed. The expressed protein localized in the mitochondria ruling out its involvement in blood brain barrier traversal. This thesis, for first time demonstrated the modification of the host plasma membrane by T. b. brucei and pointed to factors that can be exploited for the development of new interventions against African Trypanosomiasis. The study was funded by National Key Basic Research Program of China, the Organization of Women in Science for the Developing World; and supervised by Prof George W. Lubega and Assoc Prof. Enock Matovu.
SEBULIME Perigrine
SEBULIME Perigrine Phytochemical Composition of Capsicum Frutescens And Its Effect On Growth, Carcass Yield And Organoleptic Characteristics Of Indigenous And Broiler Chickens
Mr. SEBULIME Perigrine investigated phytochemical composition and dietary inclusion levels of Capsicum frutescens powder with positive effects on growth, carcass yield and organoleptic characteristics of indigenous chickens and broilers. A completely randomized design was used to conduct Capsicum frutescens feed inclusion levels experiments for broiler and indigenous chicken. It was found that C. frutescens powder had alkaloids, terpenoids, coumarins, saponins, anthracenosides and reducing compounds. The total flavonoids, phenols, alkaloids and saponins were 83.33 mgRE/100g, 587.75 mg GAE/100g, 6.8% and 23.5%, respectively. The antioxidant activity scores based on 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity at concentrations 100, 200, 400, and 500 ug/mL were 17.1, 20.8, 29.8, and 33.3%, respectively. It was shown that it was possible to improve carcass yield when C. frutescens was included at a level of 2.2% in the diets of sunflower seed cake, introduced to birds aged six months for the duration of thirty-seven days. However, there was no evidence to suggest that Capsicum frutescens could interfere with the most desirable organoleptic characteristics of the carcasses. Notably, the findings of this study offer guidance for integrating Capsicum frutescens in intensive production systems within Uganda to produce safer chicken meat with reduced risks to health of consumers.
Makerere Centre for Biosecurity and Global Health partner with VIQAP Consultancy Services and Stakeholders to Strengthen Biorisk Management Capacity among Laboratory Technologists
From 20th to 22nd October 2025, the Centre for Biosecurity and Global Health (CeBIGH) and the Department of Biosecurity, Ecosystems and Veterinary Public Health (BEP) at COVAB, Makerere University, in collaboration with VIQAP Consultancy Services, the Uganda Medical Laboratory Technologists Association (UMLTA), the Biosafety and Biosecurity Association of Uganda (BBAU), and the Uganda National Health Laboratories and Diagnostic Services, conducted a three-day Biorisk Management (Biosafety and Biosecurity) training which happened in the CeBIGH Conference room.
The training was part of an ongoing campaign to provide Continuous Professional Development (CPD) for laboratory professionals working across various sectors—including human health, animal health, environmental, biocontainment, and research laboratories. Participants included government and private laboratory technologists, graduate students of MSc Global Biosecurity and Infectious Disease Management, Clinical Epidemiology, Biomedical Laboratory Technology, as well as early-career biomedical scientists.
Participants in a group discussion during the training.
Building Competence in Biorisk Management
The Facilitation of the three-day training was led by Mr. JohnBaptist Galiwango, a certified Biorisk Management Professional by the International Federation of Biosafety Associations (IFBA) and Research Assistant in the Department of Biosecurity, Ecosystems and Veterinary Public Health (BEP), COVAB.
Mr. John Baptist Galiwango, who was the lead facilitator for the three days Biorisk Management Training.
Participants were equipped with both theoretical and practical knowledge in key areas such as:
Biosafety and biosecurity principles and practices, Biorisk Management International standards and frameworks (ISO 35001, ISO 15189, ISO 15190, BWC, UNSCR, Cartagena Protocol), Risk management and the AMP model (Assessment, Mitigation, Performance Evaluation), Laboratory design, operations, and biological waste management, Introduction to Cyberbiosecurity and Dual-Use Research of Concern (DURC) and Introduction to Emerging technologies and responsible life sciences research.
Some of the participant in an engaging group presentation.Participants in a group activity on day two of the training.
Mr. Galiwango emphasized the need for enhanced collaboration among public and private laboratory stakeholders to strengthen Uganda’s preparedness for potential emerging and re-emerging Biothreats and “Disease X.” He highlighted that a resilient laboratory system, supported by competent and well-trained personnel, is crucial in the era of rapid technological advancement. He also noted that over 200 professionals expressed interest in participating, but only a limited number could be accommodated due to resource constraints—underscoring the urgent need for more such capacity-building programs in the future.
Mr. Galiwango facilitating a Session on day Two.
Stakeholders’ Reflections and Commitments
Ms. Viola Nakidde, Managing Director of VIQAP Consultancy Services, expressed her appreciation to Makerere CeBIGH for hosting the training and for its continued commitment to professional development in the laboratory field. She reaffirmed VIQAP’s dedication to partnering with academic and professional institutions to close knowledge gaps among laboratory professionals through other CPD programs such as Internal Auditing, Laboratory Leadership and Management training and ISO Standards Implementation and support for laboratory accreditation processes.
Ms. Viola Nakidde, the Managing Director of VIQAP Consultancy Services facilitating a session.Ms. Viola Nakidde, the Managing Director of VIQAP Consultancy Services facilitating a session.
The training was officially opened by Prof. Clovice Kankya, Head of the Department of Biosecurity, Ecosystems and Veterinary Public Health , who commended the organizing team led by Mr. Galiwango and Ms. Nakidde. He encouraged participants to apply the knowledge gained for both personal and institutional growth and to seek further learning opportunities in biosafety and biosecurity.
Prof. Clovice Kankya, the Head of Department of Biosecurity, Ecosystems and Veterinary Public Health, Makerere University addressing the participants.Prof. Clovice Kankya, the Head of Department of Biosecurity, Ecosystems and Veterinary Public Health, Makerere University addressing the participants.
Delivering the keynote address, Mr. Joseph Nkodyo, National Coordinator for Biosafety and Biosecurity Programs at the Ministry of Health, pledged continued government support for private sector partners such as VIQAP Consultancy to strengthen biosafety and biosecurity systems across Uganda’s laboratories. He urged participants to apply their new skills in daily operations and to engage in research advancing biosafety and biosecurity in Uganda.
Some of the participants pose for a Photo with Mr Joseph Nkodyo (In the Middle)- The National Coordinator of Biosafety and Biosecurity programs from Ministry of Health.
Figure 9: Some of the participants pose for a Photo with Mr Joseph Nkodyo (In the Middle)- The National Coordinator of Biosafety and Biosecurity programs from Ministry of Health.
Participants and the facilitators pose for a Group photo with the National Cordinator of the Biosafety and Biosecurity programs of Ministry of Health Mr Joseph Nkodyo (Middle).
Closing Ceremony
The closing ceremony and award of certificate was presided over by COVAB’s Prof. Lawrence Mugisha, who doubles as the Chairperson of the National Biosafety Committee under the Uganda National Council for Science and Technology (UNCST). He applauded the initiative, noting that CeBIGH was the ideal venue for such technical trainings.
Prof. Lawrence Mugisha addressing the participants at the closing Ceremony.Prof. Lawrence Mugisha- the Chairperson of the National Biosafety Committee awarding Certificate to one of the active participants during the closure of the activity.
Figure 12: Prof Lawrence Mugisha- the Chairperson of the National Biosafety Committee awarding Certificate to one of the active participants during the closure of the activity.
Participants posing with their certificates and the organizing team and Prof. Mugisha after the training.
Prof. Mugisha underscored the importance of biosafety and biosecurity in the era of emerging technologies such as Artificial Intelligence (AI). He urged participants to deepen their understanding of Cyberbiosecurity, Dual-Use Research of Concern (DURC), and Gain-of-Function (GoF) Research, emphasizing responsible conduct in life sciences as a cornerstone for global health security.
Participant Feedback
Participants expressed deep gratitude for the opportunity, describing the training as a transformative experience that enhanced their professional competence. Many participants appreciated the practical and interactive approach of the facilitators and called for more frequent and sustained training programs to reach a broader group of professionals across Uganda.
The organizers of the training posing for the photo with Prof. Mugisha after closure of the training.Some of the COVAB participants and the lead facilitator after the training.
In a groundbreaking advancement for zoonotic disease research, Makerere University’s College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB) inaugurated the Tracking Trails project, an ambitious, transnational research initiative that aims to expose the spatiotemporal dynamics of free-roaming dogs and their epidemiological implications, particularly concerning rabies.
This endeavor brings together expertise from Uganda, Chad, India, Indonesia, and Switzerland, exemplifying an ideal One Health model. It integrates epidemiology, ecology, veterinary medicine, genomics, and socio-cultural anthropology, forging a transdisciplinary approach to health that is as inclusive as it is innovative.
The project under the department of Biosecurity, Ecosystems and Veterinary Public Health at CoVAB was officially launched at Fairway Hotel in in Kampala on October 16th 2025, at a ceremony attended by a consortium of national and international collaborators.
Dr. Terrence Odoch, CoVAB, Co-PI, Makerere University, and Dr. Salome Dürr of the University of Bern, the Principal Investigator, gave a brief about the project.
Dr. Salome Dürr of the University of Bern, the principal investigator, underscored the imperative of comprehending canine mobility not solely through the prism of rabies, but as a broader vector of zoonotic pathogen transmission. “Our inquiry transcends mere rabies surveillance, we intend to interrogate the health ramifications of canine movement,” she said.
Uganda as the Initial Epicenter
Uganda has been strategically designated as the inaugural locus for implementation, owing to its heterogeneous demographic fabric, divided into urban and rural ecosystems, alongside its ongoing national rabies eradication agenda. Research operations will span five districts of Kyegegwa, Masaka, Arua, Soroti, and Kampala, each offering varied ecological and socio-cultural matrices.
Dr. Terence Odoch, the Co – Principal Investigator from CoVAB Makerere University, emphasized the twofold imperative of generating actionable scientific evidence while concurrently cultivating academic capacity through the active inclusion of postgraduate cohorts.
Prof. James Acai Okwee (C) officiates at the launch of the project.
He said what distinguishes the Tracking Trails project is its integrative methodological representation that includes GPS telemetry, behavioral ecology, socio-cultural ethnography, and genomic analysis converge to address critical interrogatives, he said while giving a brief about the project. Why do dogs roam? In what ways are they embedded within human ecologies? Which movement vectors potentiate pathogen propagation? Interventions, he noted, must be established upon the understanding of these dynamics, rather than simplistic vaccination paradigms.
Contextual Complexity across Continents
A section of the implementers from the Districts who attended the launch and will play key roles.
During the launch, the different implementing countries made brief report about the status of their intended interventions and the prevailing circumstances. It was reported that in Chad, nomadic pastoralism renders canine mobility both indispensable and problematic. Professor Fayiz Abakar emphasized that prior vaccination efforts in N’Djamena achieved epidemiologically significant coverage only when rendered cost-free, underscoring the primacy of accessibility and public engagement.
For India, one of the implementing countries, it was reported that this was a home to an estimated 60 million canines, struggling with a paradoxical cultural disposition that is also spiritual in nature coupled with neglect and abandonment. Dr. Harish Tiwari delineated contrasting rural-urban movement ecologies, revealing expanded urban ranges and increased aggression post-COVID.
Some of the researchers that include PhD and Post Doc fellows taking part in the project were at the launch.
For the case of Indonesia, the situation of free roaming dogs was no any better given the socio-religiously complex set up and the endemic rabies in 26 provinces. Dr. Ewaldus Wera described distinctive behavioral adaptations in rural versus urban dogs across Flores, Lombok, and West Timor. Underscoring logistical impediments to surveillance in topographically inaccessible locales.
Rabies as a Persistent Global Threat
During the launch, officiated by CoVAB’s Deputy Principal Prof. James Acai Okwee on behalf of the Vice Chancellor, Prof. Barnabas Nawangwe , it was explained that rabies continues to pose a formidable public health threat, remaining a virulent zoonosis with a near-100% case fatality rate once clinical symptoms appear , despite being entirely preventable through timely prophylaxis.
Local and international students react to issues raised after they presented their research concepts during the Launch seminar.
Dr. Alfred Wejuli of Uganda’s Ministry of Health emphasized the urgent need for intersectoral collaboration under the One Health framework. He underscored that coordinated governance across human, animal, and environmental health sectors is indispensable for sustained disease mitigation and effective rabies control.
By equipping free-roaming dogs with GPS collars, researchers will gain real-time insights into canine movement patterns, enabling the mapping of trajectories, analysis of pack dynamics, home range variability, and interactions with human environments.
Academic and Institutional Capacity Building
Beyond empirical inquiry, the initiative is an incubator for emerging scholars. Makerere University and its partner institutions have embedded postgraduate training into the project’s architecture, equipping students with competencies in cross-disciplinary fieldwork, laboratory diagnostics, and community-based research.
Global Solidarity and Forward Trajectory
CoVAB’s Dr. Sam Okech moderated the sessions at the launch seminar.
Notwithstanding anticipated challenges ranging from logistical constraints in remote terrains to sociocultural sensitivities, the Tracking Trails project offers an unprecedented confluence of innovation, collaboration, and public health utility. As it scales across Africa and Asia, it aspires to generate an empirically grounded, culturally attuned, and ethically informed blueprint for rabies control and canine population management. Dr. Dürr encapsulated the initiative’s ethos: “Rabies transcends borders. Dog mobility defies administrative frontiers. To safeguard both human and animal health, a synergistic, global, and interdisciplinary response is imperative.”
Sekajja Agro Farms Ltd (SAF), a fully integrated poultry enterprise located in Buyuki Nama Sub-County, Mukono District, has initiated strategic discussions with Makerere University’s College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB) to establish a Graduate Trainee partnership. This collaboration is designed to bridge the persistent gap between academic instruction and practical industry experience by offering final-year students and recent graduates immersive training across the entire poultry value chain.
At a meeting held at CoVAB, the SAF team, led by Dr. Abu Mayanja, the Chief Operations Officer SAF, and the staff of the Department of Livestock and Industry Resources (LIR), a range of operations where the students would benefit were explained, ranging from feed mill production and hatchery management to broiler farming, outgrower coordination, and abattoir services, providing a rich environment for experiential learning. Dr. Abu said the initiative will not only enhance graduate employability but also foster innovation and research, and build technical capacity in Uganda’s poultry sector, while promoting knowledge exchange and entrepreneurial thinking among young professionals. Dr. Mayanja highlighted the significant human resource gap in Uganda’s poultry industry, noting that most workers acquire skills informally on the job. To address this challenge, the partnership will offer final-year students and recent graduates a six-month comprehensive training program, combining mentorship with hands-on experience across SAF’s integrated poultry operations from feed production and hatchery management to broiler farming and processing.
A section of CoVAB staff who were at the meeting deliberated on the potential partnership
Dr. Sylvia Nalubwama, along with other CoVAB staff, emphasized the strategic importance of the proposed Graduate Trainee partnership with Sekajja Agro Farms Ltd (SAF). The team highlighted that the initiative aligns well with Makerere University’s broader mission to provide education that meets societal needs, especially through practical, skills-based training. The two parties agreed to formalize the partnership following the established process, starting at the departmental level through the School of Veterinary Medicine and Animal Resources (SVAR), and concluding with approval of the Memorandum of Understanding by University Management. They also agreed that, due to the urgent workforce gaps in the poultry industry, they would begin immediate engagement and move forward with preliminary activities, including reaching out to interested students and planning the program, even while formalities are still being finalized.
Among some of the terms of the engagement is providing student facilitation, including rent, internet access, and meals, while emphasizing the importance of attitude, adaptability, and willingness to learn. Students will be selected through a merit-based application and interview process. The meeting also spoke of the need for collaboration with BTVET institutions, certification for trainees, and aligning academic programs with industry expectations.
Representatives of the final-year students in attendance expressed keen interest in the Graduate Trainee program and raised pertinent questions regarding remuneration and post-training employment opportunities. In response, representatives from Sekajja Agro Farms Ltd (SAF) acknowledged the importance of financial incentives but emphasized that the true value of the program lies in the unique exposure it offers to the commercial and operational aspects of poultry production. They assured students that the six-month training module is designed to equip them with critical skills, industry insights, and entrepreneurial competencies that are essential for driving growth and innovation within Uganda’s poultry sector.