Research
The newly refurbished CoVAB-based Research Centre for Tropical Diseases and Vector Control (RTC) Commissioned
On Friday, 1st August 2025, Prof. Barnabas Nawangwe, Vice Chancellor of Makerere University, officially inaugurated the newly upgraded Research Centre for Tropical Diseases and Vector Control (RTC) Lab at the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB). The event brought together a wide range of stakeholders, including representatives from the Ministry of Agriculture, Animal Industry and Fisheries (MAAIF), the funding partner GALVmed, the Uganda Veterinary Association (UVA), and the Uganda Animal Health Laboratory Network, staff and students of the college.
A once-outdated research lab in Uganda, as recently as 2015, has undergone a remarkable transformation, emerging as a multi-unit scientific powerhouse that now plays a pivotal role in advancing national health priorities and training students across diverse disciplines. Strategic partnerships fueled this revitalization, the most recent being the MoTAR project, Monitoring of Ticks and Acaricide Resistance in Uganda, implemented by CoVAB. With support from the Global Alliance for Livestock Veterinary Medicines (GALVmed), the MoTAR project will establish a total network of nine technically equipped laboratories across the country. The labs, three of which have been commissioned, including RTC, Gulu, and Kumi labs, will be central to diagnosing tick-borne diseases, tracking acaricide resistance, and generating data to inform national policy and improve livestock productivity.
“If I could launch laboratories every single day and do nothing else, I would,” declared Prof. Barnabas Nawangwe, Vice Chancellor, during the unveiling ceremony. “Our vision is to transform into a more research-intensive, research-led university that journey begins here.”
He emphasized the transformative power of innovation, urging the community to view research not just as an academic pursuit but as a driver of development and job creation. He commended CoVAB for its remarkable research output, attributing it to the university’s ranking.
Prof. Nawangwe encouraged researchers to embrace a mindset of creativity and production. He noted the increasing volume of patent, trademark, and copyright applications processed by the university’s intellectual property office, which, he said, was evidence that scholars were now committed to turning ideas into impactful solutions.
The Vice Chancellor applauded the critical work taking place in the RTC lab, especially in addressing livestock mortality amid growing population pressures. He challenged vaccine researchers to ensure their innovations directly respond to the urgent need to safeguard the livestock sector, which is a cornerstone of national food security and economic stability.
While addressing the issue of a lack of jobs in the country, he said the responsibility of job creation lies on the shoulders of the researchers. “It is we who must create jobs through the students we train, and the innovations we make. We want every Makerere student to go out with a company in their hands to create jobs, he said, while congratulating the RTC team for the great work done.
The RTC lab’s strategic rise from humble beginnings
According to Dr. Patrick Vudriko, Head of the Facility and Principal Investigator of the MoTAR project, the transformation began in 2011, when the lab faced challenges of outdated equipment and limited operational capacity. Fueled by a vision for change, he said, a committed team spearheaded efforts to restore and reinvent the research center. A turning point came in 2016, when Dr. Vudriko received advanced training in Japan, which, coupled with the arrival of modern equipment, marked the beginning of a structured reorganization. By 2022, the lab had evolved into a robust multi-unit research complex featuring four specialized laboratories, namely genomics, serology, pharmaceutical research and development, and a general research unit, each aligned with CoVAB’s academic departments and Uganda’s broader scientific agenda.
The upgraded RTC Lab has become a magnet for budding scientists across a wide spectrum of disciplines and institutions. While rooted within CoVAB, the facility draws active participation from other colleges at Makerere University, including the College of Engineering, Design, Art and Technology, particularly in the field of nanotechnology, the College of Health Sciences for pharmaceutical studies, the College of Natural Sciences for natural products research, and food science programs. Its national impact is further underscored by strong collaborations with external institutions such as Kyambogo University, Kampala International University (KIU), and Busitema University, and students from foreign universities. Beyond academia, the lab contributes to national health efforts as evidenced by collaborations with the FAO and JICA that have enabled community outreach, especially in Kiboga District, focusing on disease diagnostics and the management of ticks. Dr. Vudriko noted that the insights gained since 2013 stress the urgency of proactive research and rapid testing, since chemical resistance complicates tick control.
The PI explained that MoTAR, working closely with MAAIF, initiated efforts towards developing a digital National Information Management System. This integrates tick species mapping, acaricide resistance data, and pathogen tracking across Uganda’s ecologies. The refurbished and newly equipped labs will make high-quality data contributions to the system and in turn support the agricultural policy development in Uganda.
GALVmed supports small-scale livestock farmers through MoTAR
Speaking on behalf of the funding agency GALVmed, Dr. Johnson Ouma, the MoTAR Project Coordinator, expressed gratitude for the support provided by Makerere University towards the smooth project implementation. He underscored GALVmed’s mission to expand access to veterinary products and services for small-scale livestock producers, particularly those who lack the financial resources and proximity to essential inputs like drugs and diagnostics.
Dr. Ouma cited compelling research evidence that highlighted the widespread challenge of tick infestations and increasing resistance to acaricides, which has significant implications for livestock health and productivity. Thus, he explained the importance of investing in robust information systems capable of mapping acaricide resistance, tick distribution, and the prevalence of tick-borne pathogens.
He commended Makerere University for taking a leadership role in developing these innovations, with the intent that successful strategies would be replicated in other countries facing similar challenges. Dr. Ouma concluded with optimism, noting that the MoTAR project is expected to yield impactful outcomes, both locally and internationally.
Prof. Frank Norbert Mwiine Applauds RTC Lab’s Transformation
The Principal of CoVAB, Prof. Frank Norbert Mwiine, praised the RTC Lab team led by Dr. Patrick Vudriko for the impressive progress in revitalizing the laboratory. “It’s more than infrastructure; it’s a movement,” he said, emphasizing the lab’s key role in connecting classroom theory with hands-on experience.
Students are now being immersed directly into laboratory environments, gaining exposure to cutting-edge research and diagnostic techniques. Prof. Mwiine underscored that fifth-year veterinary students are actively deployed into districts, engaging with farmers and applying their knowledge on the ground.
This hands-on approach guarantees that future veterinarians are not only academically prepared but also rooted in community involvement and practical problem solving. Through training and outreach initiatives, the labs function both as learning centers and catalysts for societal change.
“We should take Makerere to the community and not the community coming to us” Prof. Mwiine added. He extended appreciation to MAAIF for the proposed 69 veterinary labs to be constructed in the country. He said the college continues to train students who will be handy in the use of the labs.
Prof. Robert Tweyongyere, Dean of the School of Veterinary Medicine and Animal Resources (SVAR), underscored the strategic importance of the RTC Lab by tracing its historical focus on tick-related research. He emphasized that tick resistance goes far beyond science, touching on economics, policy, and sustainability. “When ticks become resistant to acarisides,” he noted, “it leads to increased chemical use, higher costs, and broader socioeconomic consequences.” Prof. Tweyongyere celebrated the lab’s evolution into a national hub, now supporting other laboratories and diagnostic units in communities across Uganda. He further applauded the veterinary fraternity for its commitment to advancing animal health and spearheading diagnostic services in underserved regions.
Uganda’s latest national HIV survey reveals lower viral suppression among adolescents and young adults living with HIV than among older adults, even as the country records substantial improvements in controlling the virus. The findings come from Uganda Population-Based HIV Impact Assessment (UPHIA 2025), a national household survey examining HIV prevalence and whether people living with the virus know their status, receive treatment, and achieve viral suppression.
Releasing the preliminary UPHIA 2025 findings at the Uganda Media Centre on 1 October 2026, Minister of Health Hon. Dr. Chris Baryomunsi called for earlier prevention and testing, particularly among adolescent girls and young women, alongside support for treatment adherence. “We must reach out to the young people, ensure that they have information, they test, take treatment, and adhere to the treatment guidance,” he urged.
Hon. Baryomunsi recalled how fear had discouraged testing during his university years: “I remember when we were at university, we went for testing at the university hospital. We sat there for three hours. Some of us left without even testing because it was scary.” Today, he explained, “even if you test HIV positive, you can be initiated on treatment, and you live normally like the rest of those who don’t have HIV.”
UPHIA 2025 was locally led under the Ministry of Health’s overall leadership, with Makerere University School of Public Health serving as the prime implementer, a role ICAP at Columbia University held in the previous two surveys. The Uganda Bureau of Statistics led sampling, while the Uganda Virus Research Institute and National Health Laboratory and Diagnostic Services led laboratory operations. Regional referral hospitals and local governments supported implementation, and the U.S. government provided US$10 million through PEPFAR, along with technical assistance from the U.S. CDC.
UPHIA collected data from July to September 2025 among people aged 15 and above, including those outside routine treatment services. Of 6,283 eligible households, 94.4% completed interviews. Researchers interviewed 13,801 people and tested 13,477 for HIV.
Testing followed Uganda’s national algorithm, with laboratory confirmation of positive samples, viral-load measurement, and checks for antiretroviral medicines to establish treatment use. Researchers weighted the estimates to account for the sampling design. Participants received counselling and results, and those who tested positive were referred for treatment.
Hon. Baryomunsi thanked participants and their families for welcoming survey staff and contributing their time, information and samples, without which the national evidence would not have been available.
National progress and the youth gap
The survey estimated HIV prevalence, which means the proportion of people living with HIV, at 5.9% among those aged 15 and above, corresponding to about 1.496 million people in this age group nationwide. Prevalence was 7.3% among women and 4.1% among men, ranging from 1.3% in Karamoja to 8% in the South Western region.
Among people aged 15 and above living with HIV, 86% had achieved viral suppression, meaning a low amount of HIV in the blood, measured in UPHIA as fewer than 1,000 copies per millilitre. Suppression stood at 69.3% among adolescents and young adults aged 15–24 living with HIV, compared with 89.9% among those aged 50 and above. These estimates cover people living with HIV regardless of whether they know their status or receive treatment.
HIV prevalence among people aged 15–24 was 1.5%, including 2% among young women and 1% among young men. Among young women, prevalence was 1.3% at ages 15–19 and 2.8% at ages 20–24. These differences support attention to earlier prevention and testing, although they do not establish when infections occurred.
The highest prevalence estimates occurred among middle-aged adults: 15.7% among women aged 40–44 and 11.7% among men aged 45–49. Lower suppression among young people therefore requires attention alongside the higher HIV prevalence among middle-aged adults. Comparing the same age group across both surveys, viral suppression among people aged 15–64 increased from 74.9% in 2020–21 to 86.1% in 2025, while HIV prevalence remained at 5.9%.
Diagnosis and the path to 2030
The treatment results identify diagnosis as the main national gap. Among people aged 15 and above living with HIV, 85.3% knew their status. Of those aware, 99.1% were receiving treatment; among those receiving treatment, 96.5% had achieved suppression.
The 95-95-95 targets aimed for 95% of people living with HIV to know their status, 95% of those diagnosed to receive treatment, and 95% of those receiving treatment to achieve viral suppression by 2025. Among people aged 15 and above, Uganda exceeded the treatment and suppression targets, while diagnosis remained below target. UNAIDS’s Global AIDS Strategy 2026–2031 retains these targets towards ending AIDS as a public health threat by 2030.
According to WHO, viral suppression protects health and helps prevent HIV transmission. Uncontrolled HIV weakens the immune system, increasing the risk of serious illness. With continued treatment as prescribed, sexual transmission risk is negligible when HIV remains suppressed but detectable, and zero when undetectable. The Uganda AIDS Commission estimated over 34,000 new HIV infections in 2025, underscoring the importance of early diagnosis, timely treatment, and sustained suppression alongside other prevention measures.
The demographic stakes are substantial. People aged 15–24 constituted 21.2% of Uganda’s population in the 2024 census. The country’s Fourth National Development Plan, covering 2025–2030, prioritises a healthy, knowledgeable, skilled and productive population and reducing HIV through primary health care. Protecting young people’s health, therefore, supports their participation in education, work, and national development; UPHIA helps identify where services need greater attention.
Turning evidence into action
The study’s conclusions identify three priorities: sustain treatment outcomes, find people unaware of their status, and improve suppression among younger people. Permanent Secretary Dr. Diana Atwine connected the findings to the Ministry’s planning.
“We do believe that these results are a true reflection of what is happening in our country as far as the HIV status is concerned, and we do believe that it will give us a very clear direction and the roadmap that we are going to take in the next five years to target and to get our targets achieved.”
Acting on these priorities requires funding for services and research. Hon. Baryomunsi outlined plans to target resources where needs are greatest, strengthen district services and align partner support with government priorities. Responding to journalists’ questions, he noted the government’s intention to increase domestic funding for the HIV response, including research.
“The HIV/AIDS response, including research and surveys such as this one, has largely been funded by partners in the past. The government of Uganda is committed to allocating more resources from our domestic budget to support the response and research,” he noted.
For the first time in the UPHIA series, the survey assessed selected noncommunicable disease indicators among people aged 15 and above: 15.5% had elevated blood pressure, 24.8% were overweight or obese, and 0.9% had raised random blood glucose. These screening findings align with the Ministry’s integration agenda and Hon. Baryomunsi’s call to bring HIV and chronic care services together to address people’s wider health needs.
Speaking at the release of the preliminary results, U.S. Embassy Chargé d’Affaires Mikael (Mika) Cleverley described UPHIA 2025 as the first Population-Based HIV Impact Assessment worldwide fully led and implemented by the country itself.
“The study was led by Ugandan scientists, Ugandan managers, Ugandan public servants, Ugandan field teams, from design to data collection to analysis. And this is what two decades of focused strategic U.S. foreign investments in the public health sector was meant to produce, is to reinforce Ugandan leadership and Ugandan-led efforts.”
At the survey launch on 29 May 2025, MakSPH Dean Prof. Rhoda Wanyenze highlighted the partnership’s contribution: “The partnership between Makerere University and CDC has not only helped build national capacity in surveillance and epidemiology, but has also strengthened our ability to lead high-quality, large-scale national surveys.”
The Dean added: “After two decades of joint work, we are proud that UPHIA is now a fully Ugandan-led effort. This is critical to the sustainability of the skills and knowledge generation to inform our local response.”
UPHIA 2025 shows how far Uganda’s HIV response has advanced and where gaps remain. As the country works towards ending AIDS as a public health threat by 2030, reaching young people with testing, treatment, and continued care will be essential to extending those gains.
Read the full UPHIA 2025 summary results here:
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