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72nd Graduation: Doctoral Citations – CHS

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AGABA Bekiita Bosco
AGABA Bekiita Bosco

AGABA Bekiita Bosco
Molecular Epidemiological Surveillance of pfhrp2 and pfhrp3 gene deletions in Plasmodium falciparum parasite populations in Uganda

Mr. AGABA Bekiita Bosco investigated the biological and molecular changes in malaria parasites that make them difficult to be detected in malaria infected individuals. Once these parasites evade detection, individuals remain untreated leading to severe disease and risk of mortality. The results provide the first large-scale evidence reporting the presence of pfhrp2/3 gene deletions in P. falciparum parasites in Uganda and demonstrated that gene deletions are not confined but rather spread across regions. Further, the study showed that these parasites emerge independently and sponteneously. The findings inform national guidelines for malaria case management and policy for the introduction and deployment of new malaria diagnotic tests. The study was funded by the NIH-Fogarty Malaria training grant and the WHO collaborating center in Australia. The work was supervised by Prof. Moses R. Kamya, Prof. Chae Seung Lim, Dr. Adoke Yeka and Dr. Samuel Nsobya.


AMONGIN Dinah
AMONGIN Dinah

AMONGIN Dinah
Understanding Trends and Trajectories of Repeat Adolescent Birth in Uganda

Ms. AMONGIN Dinah studied the magnitude and explanation for repeat adolescent birth (i.e. a second or higher order live birth before age 20 years, following a first birth before age 18 years) and its later life consequences in Uganda. Her results revealed high repeat adolescent births (over 1 in 2) with slight decline in the 30 years of observation (1988/89-2016) although more women over the years wanted to have this repeat birth later. Results suggest life-long negative socio-economic and reproductive health outcomes among women with repeat adolescent births compared to those without. Further, escalation of the socio-economic distress following first birth, domestic violence, and partner coercion, predisposed adolescent girls to sexual exploitation and unwanted marriages. Interventions should focus on preventing repeat adolescent pregnancy and increasing opportunities for adolescent mothers, with a primary focus on: improving school retention/continuation, strengthening family planning services, and preventing early marriage. This study was funded by Training Health Researchers into Vocational Excellence (THRiVE-2) and was supervised by Assoc. Prof Annettee Nakimuli, Assoc. Prof Lenka Benova, Assoc. Prof Lynn Atuyambe, and Assoc. Prof Claudia Hanson.


KAPAATA ANDAMA Anne
KAPAATA ANDAMA Anne

KAPAATA ANDAMA Anne
Genotypic And Phenotypic Characterization Of Hiv-1 Transmitted/Founder Viruses And Their Effect On Cytokine Profiles And Disease Progression Among Acutely Infected Ugandans

Ms. KAPAATA ANDAMA Anne looked at Genotypic and Phenotypic Characterization of HIV-1 transmitted/founder viruses and their effect on cytokine profiles and disease progression among acutely infected Ugandans. Subtype analysis of inferred transmitted/founder viruses showed a high transmission rate of inter-subtype recombinants (69%) involving mainly A1/D, while pure subtype D variants accounted for one- third of infections (31%). The signal peptide-C1 region and gp41 transmembrane domain were hotspots for A1/D recombination events. She documented diversity in the functional protein domains across the Gag-Pol region of the HIV virus and identified differences in the Gag-p6 domain that were frequently associated with higher in vitro replication. She also found that HIV-1 subtype D infections had higher concentrations of different cytokines than subtype Ainfections. cytokines IL-12/23p40 and IL-1α were associated with faster CD4+T cell count decline while basic fibroblast growth factor was associated with maintenance of CD4+T cell count above 350cells/microliter. This work was funded by the International AIDS Vaccine initiative and supervised by Prof. Pontiano Kaleebu, Eric Hunter and Moses Joloba and Dr Jesus Salazar Gonzalez.


BAKESIIMA Ritah
BAKESIIMA Ritah

BAKESIIMA Ritah
Modern contraceptive use among female refugee adolescents in northern Uganda: prevalence, effect of peer counselling, adherence and experiences

Ms. BAKESIIMA Ritah studied modern contraceptive use among female refugee adolescents northern Uganda: the prevalence, effect of peer counselling, adherence, and experiences. She found that the use of modern contraceptives among sexually active adolescents was very low with less than 10% using a method, and yet they wanted to delay child birth. This highlights a high unmet need of contraceptives in this population. She also found that peer counselling had a positive effect on acceptance of modern contraceptives; participants who received peer counselling were more likely to accept a contraceptive method compared to those who received routine counselling. The commonest reasons for non-acceptance of a method were partner prohibition and fear of side effects. She recommends that refugee adolescents, together with their partners, are further sensitized of the dangers of teenage pregnancy, and the benefits of contraception in preventing teenage pregnancy and associated complications. This research was funded by SIDA and supervised by Assoc. Prof Elin Larsson, Dr. Jolly Beyeza-Kashesya, Prof. Kristina Gemzell-Danielsson, Dr. Amanda Cleeve, and Dr. Rose Chalo Nabirye.


BAYIGGA Lois
BAYIGGA Lois

BAYIGGA Lois
Role of Vaginal Microbiome in Host Susceptibility of HIV Infection in Pregnant Ugandan Women: Inflammatory Response and Epithelial Barrier Integrity

Mr. BAYIGGA Lois investigated the virginal microbial diversity and its immune-modulatory effects on host susceptibility to HIV among pregnant women in Uganda. In the results, the vaginal microbiome of pregnant women in the cross-sectional study was categorised into four distinct cervicotypes. In conclusion, African women had a more diverse vaginal microbiome relative to women in the America and Europe as observed in the literature. This work was supervised by Prof. Damalie Nakanjako, Dr. David Patrict Kateete, Dr. Musa Sekikubo and Prof. Deborah Anderson.


MIJUMBI Deve Rhona
MIJUMBI Deve Rhona

MIJUMBI Deve Rhona
Rapid Response Services to Support Policymaking in Uganda

Ms. MIJUMBI Deve Rhona evaluated the rapid response mechanisms aimed at providing evidence for policymaking in Uganda, including their feasibility and establishment, their uptake amongst the users along with these users’ experiences with them. She was able to determine and confirm the feasibility of an RRS in Uganda and map the establishment, growth, and evolution of the service. She was also able to document the important factors that led to the establishment of the service, then used this information to develop a theoretical framework combining the structural and temporal components of the development of an RRS and the factors important at each stage. She also established the important factors that influence the uptake of the RRS amongst its actual and potential users and also explored the users’ experience with the rapid response (RR) briefs produced by the RRS and used her findings to improve these briefs. The findings from this work are important to enable the use of evidence for decision-making at different levels of governance globally, especially in complex situations where time is barred. The work was funded by the International Development Research Center’s International Research Chairs Initiative and supervised by Prof. Nelson Sewankambo, Prof. John Lavis, and Dr. Andrew Oxman.


MUKURU Moses
MUKURU Moses

MUKURU Moses
An analysis of evolutions in maternal health policies and implementation adaptations in Uganda during the MDG period (2000-2015)

Mr. MUKURU Moses analysed Uganda’s maternal health policies introduced during the fifteen years of the Millennium Development Goals (MDG period) to understand policy failure. This followed the persistence of high preventable maternal mortality, which closed at a Maternal Mortality Ratio (MMR) of 368 deaths per 100,000 live births in 2015 below the target of 131 deaths per 100,000 live births. While most studies explain the failure to achieve maternal health policy targets from epidemiological, interventional and health systems perspectives, this study examined how elite interests underpinning maternal health policies, policy design and implementation influenced maternal health policy failure in Uganda. The study found that the failure to achieve policy targets and persistence of high maternal mortality despite introducing fourteen policy shifts emanated from a complex interplay of factors at the policy formulation, design and implementation levels. Policy elites developed policies which mainly served their selfish political and economic interests while paying limited attention to the goal of reducing maternal mortality. The policy instruments introduced were incoherent, inconsistent and incomprehensive to cover all the causes of maternal mortality rendering the policies ineffective in design. Consequently, maternal health policies could not be fully operationalised at the frontline to support timely response to all the emergencies that cause maternal death. The study was funded by DAAD, the Alliance for Health Policy and Systems Research, Switzerland, through the University of Cape Town, South Africa, the “Support Policy Engagements for Evidence informed (SPEED)” and was supervised by Professor Freddie Ssengooba and Dr Suzanne Kiwanuka.


MUSABA Milton
MUSABA Milton

MUSABA Milton
Obstructed labour in Eastern Uganda: risk factors, electrolyte derangements, and effect of bicarbonate on obstetric outcomes

Dr. MUSABA Milton studied the risk factors, electrolyte derangements, and effect of bicarbonate on obstetric outcomes among women with Obstructed labour (OL). Failure of a woman to give birth normally is called OL. It is often associated with poor outcomes for both the mother and baby, if the intervention (surgical) is not timely. In Uganda, one in five maternal deaths and two in five perinatal deaths are attributed to OL. The risk factors were being a first-time mother, using herbal medicines, and being referred in labour. While being married, having a delivery plan, and an educated partner were protective. Perioperatively, multiple electrolyte derangements were common. Perinatal death was four times higher than the national average, and the predictors were being referred and having a high maternal blood lactate level. Sodium bicarbonate infusion had no significant beneficial or harmful effect. Developing birth and complication readiness plans may help to minimize delays and multiple referrals in case of an emergency. To minimize the effects of metabolic and electrolyte derangements in OL, healthcare providers need to ensure that these patients are well rehydrated especially during transfer to a higher facility. This study was funded by NORHED/NORAD and was supervised by Prof. Grace Ndeezi, Prof. Julius N. Wandabwa, Dr. Justus K. Barageine, and Prof. Andrew D. Weeks


NAMAZZI Gertrude
NAMAZZI Gertrude

NAMAZZI Gertrude
Burden and risk factors for child developmental disability among infants in Busoga region, in Uganda

Dr. NAMAZZI Gertrude investigated the burden and risk factors for child developmental disability among infants in Busoga region, in Uganda. The study revealed a high burden of child developmental disability at population level and among preterm babies. The caretakers of children with developmental disability expressed emotional stress and an impoverishing experience with limited support from the community and the health system. The key risk factors included: birth asphyxia, malnutrition, newborn infections, and a mother having more than three children. The study findings indicate the need to improve the quality of care during delivery and the postnatal period to prevent birth asphyxia, neonatal infections and malnutrition so as to curb the burden of child developmental disability. In addition, parents should limit the number of children to those they are able to nurture and care for adequately. The study recommends to government to improve the health facility readiness to respond to caretakers’ needs and the needs of children with developmental disability so as to empower families, while respecting their beliefs, to cope with adversity. The study was funded by SIDA and was supervised by Prof. James Tumwine, Assoc. Prof. Peter Waiswa and Assoc. Prof. Helena.


NANKYA Mutyoba Eron Joan
NANKYA Mutyoba Eron Joan

NANKYA Mutyoba Eron Joan
Hepatitis B. Among Ugandan pregnant women: Studies on Epidemiology, knowledge, perceptions and behavioural intentions

Ms. NANKYA Mutyoba Eron Joan investigated the epidemiology, knowledge, perceptions and behavioural intentions associated with Hepatitis B among Ugandan pregnant women. The study was conducted among pregnant women attending routine Antenatal Care in public health facilities in Kampala, Wakiso and Arua Districts. In the results, the overall prevalence of Hepatitis B. Virus infection was 6.1%. Pregnant women in Uganda have a high burden of the virus with significant regional differences, low knowledge and inaccurate perceptions of the virus. This study was funded by SIDA and was supervised by Assoc Prof. Ponsiano Ocama, Asoc Prof. Fredrick Makumbi and Assoc Prof. Lynn Atuyambe.


ODEI OBENG-AMOAKO Gloria Adobea
ODEI OBENG-AMOAKO Gloria Adobea

ODEI OBENG-AMOAKO Gloria Adobea
Retrospective analysis of concurrently wasted and stunted children 6-59 months in the outpatient therapeutic feeding programme in Karamoja: burden, characteristics, detection, response to treatment and outcomes

Ms. ODEI Obeng-Amoako Gloria Adobea examined the burden, characteristics and detection of concurrently wasted and stunted among children under 5 years, and their response to treatment and outcomes in the outpatient therapeutic feeding programme in Karamoja. She found that 5% of children under-5 years in Karamoja were wasted and stunted concurrently. Concurrent wasting and stunting was common among children younger than 3 years and particularly males. She identified optimal weight for age z-score (WAZ) and mid upper arm circumference (MUAC) thresholds for detecting children with concurrent wasting and stunting. Nearly half (49%) of children with severe acute malnutrition receiving outpatient therapeutic care were concurrently wasted and stunted and had lower recovery rate. The study will inform decision-making on integrated wasting and stunting prevention and treatment policy and programme. This study was funded by Carnegie Corporation of New York through RUFORUM, UNICEF Uganda; and African Union and European Union-Intra-ACP Mobility Partnering for Health Professionals Training in African Universities (P4HPT) and supervised by Assoc. Prof Charles A. S. Karamagi and Dr. Henry Wamani.


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Health

Call For Applications: Masters Support in Self-management Intervention for Reducing Epilepsy Burden

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An aerial photo of the College of Health Sciences (CHS), Makerere University showing Left to Right: The Sir Albert Cook Memorial Library, School of Biomedical Sciences, Davies Lecture Theatre, School of Public Health, Mulago Specialised Women and Neonatal Hospital (MSWNH)-Background Left and Nakasero Hill-Background Right, Kampala Uganda.

The Makerere University College of Health Sciences & Case Western Reserve University, partnering with Mbarara University of science and Technology are implementing a five-year project, “Self-management Intervention for Reducing Epilepsy Burden Among Adult Ugandans with Epilepsy”.

The program is funded by the National Institute of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS). One aspect of the program is to provide advanced degree training to qualified candidates with an interest in pursuing clinical and research careers in Epilepsy. We are aiming at growing epilepsy research capacity including self-management approaches in SSA.

The Project is soliciting for applications for Masters Research thesis support focusing on epilepsy related research at Makerere University and Mbarara University, cohort 1, 2024/2025.

Selection criteria

  • Should be a Masters’ student of the following courses; MMED in Internal Medicine, Paediatrics, Surgery and Neurosurgery, Psychiatry, Family Medicine, Public Health, Master of Health Services Research, MSc. Clinical Epidemiology and Biostatistics, Nursing or Masters in the Basic Sciences (Physiology, Anatomy, Biochemistry or any other related field).
  • Should have completed at least one year of their Masters training in the courses listed above.
  • Demonstrated interest in Epilepsy and Neurological diseases, care and prevention and commitment to develop and maintain a productive career and devoted to Epilepsy, Clinical Practice and Prevention.

Research Programs

The following are the broad Epilepsy research priority areas (THEMES) and applicants are encouraged to develop research concepts in the areas of; Applicants are not limited to these themes; they can propose other areas.

  • The epidemiology of Epilepsy and associated risk factors.
  • Determining the factors affecting the quality of life, risk factors and outcomes (mortality, morbidity) for Epilepsy, epilepsy genetics, and preventive measures among adults.
  • Epilepsy in childhood and its associated factors, preventative measures etc.
  • Epilepsy epidemiology and other Epilepsy related topics.
  • Epilepsy interventions and rehabilitation

In addition to a formal masters’ program, trainees will receive training in bio-ethics, Good Clinical Practice, behavioral sciences research, data and statistical analysis and research management.

The review criteria for applicants will be as follows:

  • Relevance to program objectives
  • Quality of research and research project approach
  • Feasibility of study
  • Mentors and mentoring plan; in your mentoring plan, please include who are the mentors, what training they will provide and how often they propose to meet with the candidate.
  • Ethics and human subjects’ protection.

Application Process

Applicants should submit an application letter accompanied with detailed curriculum vitae, two recommendation letters from Professional referees or mentors and a 2-page concept or an approved full proposal describing your project and addressing Self-Management Intervention for Reducing Epilepsy Burden Among Adult or epilepsy related problem.

A soft copy should be submitted to the Administrator, Reducing Epilepsy Burden Project.  Email: smireb2@gmail.com; Closing date for the Receipt of applications is 1st July 2024.

For more information, inquiries and additional advice on developing concepts, please contact the following:

Makerere University College of Health Sciences

Prof. Mark Kaddumukasa:  kaddumark@yahoo.co.uk

Mbarara University

Ms. Josephine N Najjuma: najjumajosephine@yahoo.co.uk

Only short-listed candidates will be contacted for Interviews.

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Call For Applications: Masters Support in Brain Health

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Artistic illustration of Medical Science at the College of Health Sciences (CHS), Makerere University, Kampala Uganda.

The Makerere University College of Health Sciences and Uganda Martyrs University (UMU), Research Training and mentorship to strengthen brain health program is a five-year project, funded by the National Institute of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) and the Fogarty International Center (FIC). The Major goal is to strengthen brain health research through multidisciplinary training and build a sustainable faculty and institutional capacity for research to improve brain health across the Lifespan in Uganda.

The Project is soliciting for applications for Master’s training support in Brain Health-related research at Makerere University/UMU, 5th Cohort, 2024/2025.

Selection criteria

  • Should be a Masters’ student of the following courses; MMED in Internal Medicine, Obstetrics/Gynaecology, Paediatrics, Surgery and Neurosurgery, Psychiatry, Family Medicine, Public Health, Master of Health Services Research, MSc. Clinical Epidemiology and Biostatistics, Nursing or Masters in the Basic Sciences (Physiology, Anatomy, Biochemistry or any other related field at Makerere University/UMU.
  • Should have completed at least one year of their Masters training in the courses listed above and ready to start their thesis development.
  • Proof of admission onto a master’s program at Makerere or UMU
  • Research work should be related to their selected research area in brain health
  • A letter of support from a mentor and another letter from the department committing to give the candidate protected time to study.
  • Demonstrated interest in Brain Health and Neurological diseases, care and prevention and commitment to develop and maintain a productive career and devoted to Brain Health, Clinical Practice and Prevention.

Research Programs

The following are the broad Brain Health Research priority areas (THEMES) and applicants are encouraged to develop research concepts in the areas of; Meningitis, encephalitis, traumatic brain injury, seizures/ epilepsy, neurodevelopmental disorders, ADHD, Autism, cerebral palsy, mental health disorders, stroke, dementias, Parkinson’s disease and nerve disorders plus “other brain-related topics”

In addition to a formal masters’ program, trainees will receive training in bio-ethics, Implementation science, behavioral sciences research, qualitative and quantitative research methodology, data analysis and research management.

The review criteria for applicants will be as follows:

  • Relevance to program objectives
  • Quality of research and research project approach
  • Feasibility of study
  • Mentors and mentoring plan; in your Mentoring plan, please include who are the proposed mentors, what training they will provide and how often they propose to meet with the candidate.
  • Ethics and human subjects’ protection.

Application Process

Applicants should submit an application letter accompanied with a detailed curriculum vitae, two recommendation letters from Professional referees or mentors and a 2-page concept or approved full proposal addressing a brain health or neurological disease related problem.

A soft copy should be submitted to the Training Coordinator, Brain Health Project.

Email: brainhealthtraining@gmail.com.

Closing date for the Receipt of applications is 10th June 2024.

For more information, inquiries and additional advice on developing concepts, please contact the following:

Prof. Elly Katabira, katabira@infocom.co.ug;

Dr. Mark Kaddumukasa. kaddumark@yahoo.co.uk

Only short-listed candidates will be contacted for Interviews

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Call For Applications: Masters Support in Reducing Stroke Risk Factors

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The Dean’s Gardens with Davies Lecture Theatre (Right), College of Health Sciences, Makerere University, Mulago Hill, Kampala Uganda on a bright sunny day. East Africa

The Makerere University College of Health Sciences and Case Western Reserve University, partnering with Mbarara University of Science and Technology are implementing a five-year project, “A targeted self-management Intervention for Reducing Stroke Risk Factors in High Risk Ugandans”.

The program is funded by the National Institute of Health (NIH), the National Institute of Neurological Disorders and Stroke (NINDS). One aspect of the program is to provide advanced degree training to qualified candidates with an interest in pursuing clinical and research careers in Stroke. Trainees will be expected to develop and maintain a productive career devoted to Stroke Research, Clinical Practice, and Prevention. We are aiming at growing Research Capacity in Stroke Risk Reduction and training the next generation of Stroke health in Sub-Saharan Africa.

The Project is soliciting for applications for Masters Research thesis support in stroke-related research at Makerere University and Mbarara University, cohort 5, 2024/2025.

Selection criteria

  • Should be a Masters’ student of the following courses; MMED in Internal Medicine, Paediatrics, Surgery and Neurosurgery, Psychiatry, Family Medicine, Public Health, Master of Health Services Research, MSc. Clinical Epidemiology and Biostatistics, Nursing or Masters in the Basic Sciences (Physiology, Anatomy, Biochemistry or any other related field).
  • Should have completed at least one year of their Masters training in the courses listed above.
  • Demonstrated interest in Stroke and Neurological diseases, care and prevention and commitment to develop and maintain a productive career and devoted to Stroke, Clinical Practice and Prevention.

Research Programs

The following are the broad brain health research priority areas (THEMES) and applicants are encouraged to develop research concepts in the areas of; Applicants are not limited to these themes, they can propose other areas.

  • The epidemiology of Stroke and associated risk factors.
  • Stroke risk factors and outcomes (mortality, morbidity) for stroke, stroke genetics, and preventive measures in among adults.
  • Stroke in childhood and its associated factors, preventative measures etc.
  • Stroke epidemiology and other stroke related topics.
  • Stroke interventions and rehabilitation

In addition to a formal masters’ program, trainees will receive training in bio-ethics, Good Clinical Practice, behavioral sciences research, data and statistical analysis and research management.

The review criteria for applicants will be as follows:

  • Relevance to program objectives
  • Quality of research and research project approach
  • Feasibility of study
  • Mentors and mentoring plan; in your mentoring plan, please include who are the mentors, what training they will provide and how often they propose to meet with the candidate.
  • Ethics and human subjects’ protection.

Application Process

Applicants should submit an application letter accompanied with a detailed curriculum vitae, two recommendation letters from Professional referees or mentors and a 2-page concept or an approved full proposal describing your project and addressing Stroke Risk Factors or a stroke related problem.

A soft copy should be submitted to the Training Coordinator, Reducing Stroke Project.

Email: reducingstroke@gmail.com. The closing date for the Receipt of applications is 10th June 2024.

For more information, inquiries, and additional advice on developing concepts, please contact the following:

Makerere University College of Health Sciences

Prof. Elly Katabira: katabira@infocom.co.ug

Dr. Mark Kaddumukasa:  kaddumark@yahoo.co.uk

Mbarara University

Ms. Josephine N Najjuma: najjumajosephine@yahoo.co.uk

Only short-listed candidates will be contacted for Interviews.

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