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Mak 70th Grad PhD Citations Session 1, Part 3

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College of Health Sciences (CHS)

 

BBOSA Nicholas

A molecular phylogenetic and modelling approach towards understanding the transmission dynamics and genetic diversity of HIV-1 in the fishing communities of Lake Victoria, Uganda

Dr. BBOSA Nicholas used molecular phylogenetic and modelling approaches to dissect the transmission dynamics of HIV in the fishing communities of Lake Victoria. The fishing communities are disproportionately affected by HIV relative to the general population and for a long time, the dynamics of HIV transmission were not well understood. His research revealed for the first time in Uganda that the fishing communities were a sink for HIV transmission from the general population and negated the generally held assumption of the fishing communities being viral reservoirs. The findings have contributed towards informing public health policies on the implementation of targeted interventions for effective HIV epidemic control in most at-risk populations. This study was funded by the UK Medical research council, and was supervised by Prof. Pontiano Kaleebu, Prof. Andrew Leigh-Brown, Dr. Bernard S. Bagaya, Assoc. Prof Noah Kiwanuka and Dr. Rebecca N. Nsubuga.

 

BWIRE Godfrey

Molecular characterization and rapid detection of Vibrio cholerae in Uganda: the relationship between human pathogens and aquatic environment.

Dr. BWIRE Godfrey studied Vibrio cholerae, the bacteria responsible for repeated cholera outbreaks in Uganda to determine their genetic profile, spread, transmission, virulence, aquatic environmental reservoirs and a field cholera rapid diagnostic test (RDT). The study found that cholera outbreaks in Uganda were due to three genetically related V. cholerae clones. The clones showed transmission within Uganda, East and Central African regions. The surface water sources in Uganda were possibly not reservoirs for the epidemic V. cholerae. The accuracy of the cholera RDT, a modified Crystal VC® dipsticks was high. This study enhances our understanding of cholera outbreaks and may help in prevention, control and elimination of cholera in Uganda. The study was jointly funded by the Uganda Ministry of Health and Bill and Melinda Gates Foundation (USA) and supervised by Prof. Christopher Garimoi Orach (MakSPH) and Prof. David Allen Sack (John Hopkins University, USA).

 

EGESA Moses

Human B and T cell responses to novel Schistosoma mansoni skin-stage antigens

Mr. EGESA Moses studied human immune responses to parasite components expressed at the vulnerable skin larva stage of the human blood fluke, Schistosoma. It was not known how endemic populations respond to recombinant components of the larvae and how these immune responses relate with intensity of infection when people get re-infected. The recombinant antigens induced inflammatory cytokine responses. Additionally, antibodies to these antigens were detectable and were affected by treatment. Although not associated with reinfection intensity, the information generated informs the selection and prioritization of vaccine targets. This study was funded by a Wellcome Trust Strategic Award and the DELTAS Africa Initiative and supported by European Commission’s Seventh Framework Programme, and was supervised by Dr. Bernard Bagaya, Prof. Maria Yazdanbakhsh and Dr. Stephen Cose.

 

KADDUMUKASA Martin

Sodium intake in post-stroke patients – its influence on blood pressure, knowledge and perceptions and stroke outcomes in Uganda

Dr. KADDUMUKASA Martin’s thesis focuses on salt intake and cardiovascular stroke. He estimates the daily intake and its association with blood pressure and stroke. He further investigates knowledge, perceptions, and consumption decisions after stroke. He uses 24-hour urine to determine the salt intake in stroke patients. He notes that stroke survivors with high blood pressure have twice the levels of salt compared to stroke survivors without blood pressure. Poor knowledge, perceptions, and salt use beliefs. Finally, a high frequency of stroke recurrence and death was observed in this group. This study recommends primary stroke prevention through salt intake reduction and population salt awareness through education. This study was supported by NIH MEPI-linked Neurology Award (No. 5R24TW008886), Fogarty International Centre and was supervised by Prof. E. Katabira, Prof. Martha Sajatovic, Prof. Larry Goldstein and Dr. Pundik.

 

KAYIMA James

Hypertension in Uganda: epidemiology and association with HIV infection and genetics

Dr. KAYIMA James investigated the association of HIV infection and selected genes with blood pressure traits among Ugandans. He observed that, unlike the western populations, the frequency of hypertension was lower among HIV-infected compared to uninfected subjects in Uganda. Further, he uncovered the profound negative effect of SUB/NPR3 gene on systolic blood pressure. These finding suggest a protective effect of HIV on hypertension; and a potential modifying effect of SUB/NPR3 gene on hypertension in African populations. This work elucidates the role of HIV and population-specific genetic factors in the control of hypertension risk. It builds a foundation for formulation of prevention efforts for cardiovascular disease among high-risk groups; and for pharmacogenetic studies to identify appropriate medication for hypertensive black populations. This study was funded by Medical Education Partnership Initiative on Cardiovascular Disease (MEPI-CVD), and was supervised by Dr. Achilles Katamba, Prof. Harriet Mayanja Kizza, Prof. Xiaofeng Zhu and Prof. Mahboob Rahman.

 

MBOOWA Gerald

Functional host-genetic loci associated with pediatric HIV-disease progression in Uganda and Botswana

Dr. MBOOWA Gerald used genomics and bioinformatics approaches to identify a set of genes that informs us which person if HIV-infected will take many years to develop AIDS (symptoms) without HIV-treatment. His research revealed that following HIV infection, there are two groups of people; Rapid-AIDS progressors (develop symptoms in 3-years or less after infection) and Long-term non-progressors (>10-years to develop symptoms) without HIV-treatment. These findings have implications for the current “Test-and-Treat and Treat-for-Life” HIV-treatment policy; when one tests HIV-positive and started on treatment-for-life exposing them to drugs’ dangerous side-effects yet some HIV-infected people have nature ability to stay for many years without developing symptoms in absence of HIV-treatment. This study was funded by the Collaborative African Genomics Network-(CAfGEN) and Training Health Researchers into Vocational Excellence in East Africa-(THRiVE-2), and supervised by Prof Moses Joloba and Dr. David Kateete.

 

MPIMBAZA Arthur Mwambari

Determinants of severe malaria among children hospitalised at Jinja Regional Referral Hospital, Uganda

Dr. MPIMBAZA Arthur Mwambari studied determinants of severe malaria among children in the Busoga sub-region. Risk factors for severe malaria included delayed care seeking by more than 24 hours after fever onset and seeking care at a drug shop as the initial response. For convenience, drug shops were the most common provider sought by caregivers of children with severe malaria. However, drug shops offered sub-optimal healthcare services compared to public health facilities. Hemoglobin S heterozygotes, alpha thalassemia heterozygosity and homozygosity were associated with protection against severe malaria. Drug shops were a problem, contributing to delay and severe malaria. The role of drug shops in caring for children with malaria needs to be re-evaluated and services at public health facilities strengthened. This study was funded by NIH Fogarty International Center (TW009343 and TW007375) and was supervised by Assoc. Prof. Charles Karamagi, Prof. Anne Katahoire, Grace Ndeezi and Philip J Rosenthal.

 

NABATANZI Rose (Ms)

Innate immune system recovery after long-term antiretroviral therapy in an African cohort

Dr. NABATANZI Rose studied whether key blood cell populations of HIV infected adults recover completely after at least seven years of treatment with antiretroviral therapy (ART). This research found that despite at least seven years of effective ART, key first line defence cells among HIV-infected individuals were still fewer and produced low chemical mediators of first line defence against invading germs; compared with age-matched healthy HIV uninfected individuals. More emphasis should be put on ways of improving the body’s defence system for individuals on long-term ART to levels comparable to HIV-uninfected individuals, to prevent or delay HIV-associated complications among adults aging with the disease. This study was funded by DELTAS Africa Initiative, the Wellcome Trust and UK government and Alliance for Global Health and Science at University of California, Berkeley, USA; and was supervised by Prof. Damalie Nakanjako, Prof. Moses Joloba, Prof. Stephen Cose and Prof. Sarah Rowland Jones.

 

NAJJUKA Christine Florence (Ms)

Characterisation of extended spectrum Beta lactamases elaborated in Enterobactereaceae in Uganda

Dr. NAJJUKA Christine Florence investigated the prevalence of Extended Spectrum beta-Lactamases (ESBLs), the factors associated with gastrointestinal carriage, genotypes, transmission dynamics and co-resistance among clients attending outpatient clinics in Kampala, Kayunga and Mpigi Districts. She found predominance of cefotaximase in Kampala and presence of plasmid-mediated AmpC beta-lactamase genes, especially in ceftriaxone-susceptible Escherichia coli. Use of ciprofloxacin, inoculation and routine health follow up were risk factors, while rural residency and visiting lower health centres were protective of carriage of resistant bacteria. Transmission was predominantly by horizontal gene transfer of cefotaximase with at least two non-beta-lactam resistance genes. The findings inform widespread gut colonisation by bacteria resistant to 3rd generation cephalosporins and commonly used non beta-lactam agents, a source for transmission and infection with unpredictable and limited treatment options. This study was funded by Sida-Makerere Bilateral Research Programme and the Carnegie Cooperation of New York, and was supervised by Prof. Moses L. Joloba and Prof. Sabiha Y. Essack.

 

ZIDA Andre

Creating and institutionalizing supports for evidence-informed decision making, including a rapid response service, in the Burkina Faso health system

Dr. ZIDA Andre’s research focused on decision making in the Burkina Faso health system. His investigation focused on the institutionalization of a policy support unit called rapid response to provide evidence for urgent decision-making. The study showed that the institutionalization of decision support units demands a robust framework and political will. It can be non-linear, and it depends on the leadership of unit managers to implement relevant activities, mobilize funding, and recruit and maintain sufficient human resources. This study developed a clear roadmap for evidence-informed decision-making and policy unit institutionalization. This study was funded by International Development Research Centre (IDRC) and the European Union, and was supervised by Prof. Nelson K. Sewankambo, John N. Lavis and Dr. Bocar Kouyate.

 

Please click the links below to navigate to the PhD Citations for the respective Sessions.

< Director’s Message | Session 1: Part1 : Part2 : Part3 | Session 2 | Session 3 | Session 4 >

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Mark Wamai

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Women in Business Empowered at Makerere

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Prof. Sarah Ssali (Seated 3rd Right) with officials and participants during the Women in Business training on 20th August 2025. Institute of Gender and Development Studies in partnership with the United Nations Development Programme (UNDP), training program focusing on procurement and business development for women in business, 20th August 2025, Yusuf Lule Central Teaching Facility Auditorium, Makerere University, Kampala Uganda, East Africa.

Makerere University, through the Institute of Gender and Development Studies in partnership with the United Nations Development Programme (UNDP), on 20th August 2025 commenced a training program focusing on procurement and business development for women in business. The two sessions, which brought together women from diverse business sectors, were held at the Yusuf Lule Central Teaching Facility. The training covered critical areas such as business requirements and strategic positioning, access to credit—particularly the Women in Business initiative by Stanbic Bank—and navigating procurement processes in the public service, among other vital aspects.

In his remarks, Mr. Paul Agaba, Director of the Procurement and Disposal Unit (PDU) at Makerere University, outlined relevant laws and shed light on reservation schemes for women-owned businesses. He detailed the requirements for companies to participate in procurement reserved for women, the necessary qualifying documents, and the benefits associated with such schemes. Mr. Agaba referred to the Public Procurement and Disposal of Public Assets (PPDA) Act of 2003, a law aimed at regulating procurement processes while enhancing service delivery and ensuring value for money. He noted that the Act has undergone several amendments to address emerging issues and reinforce principles of fairness and inclusivity, including measures to integrate previously marginalized groups—women, youth, and persons with disabilities—into business opportunities.

He further emphasized that reservation schemes are designed to provide incentives for women-owned businesses. To qualify, a business must be registered with the appropriate authorities, with at least 51% of its shares owned by one or more Ugandan women. On specific requirements, he highlighted the need for registration with the Uganda Registration Services Bureau (URSB), annual registration with the PPDA to be listed among providers, and documentation proving 51% female shareholding. However, Mr. Agaba noted that more effort is needed to actualize some provisions, such as ensuring that 15% of every procurement plan in public institutions and all procurements below UGX 30 million are reserved for women.

Representing UNDP, Ms. Beatrice Nabagya Mugambe, whose organization funded the training, underscored the importance of the program, describing it as a response to critical gaps identified through organizational assessments and surveys. She observed that despite ongoing efforts in gender-responsive procurement, women’s participation in procurement processes remains limited—a challenge not unique to Makerere but also evident across other agencies. She pointed to barriers such as lack of capital, insufficient information about bid opportunities and procedures, perceptions that bid amounts are beyond their reach, and limited business networks that could otherwise facilitate collective bidding. She stressed that such limitations can be overcome through collective action.

Addressing the topic of access to credit, Mr. Joel Mukasa, Relationship Manager at Stanbic Bank, highlighted opportunities available to women-owned businesses through the bank. Drawing from over seven years of experience, he noted that women tend to be better business managers, with 90% of loans disbursed to women being repaid, compared to less than 50% among men, attributing the gap to men often diverting business funds for personal use. Mr. Mukasa explained that Stanbic Bank has established several initiatives tailored for women, including the ‘Grow Project’ in partnership with the Private Sector Foundation Uganda (PSFU) and the government, and the ‘Stanbic for Her’ program. He clarified that the ‘Grow Project’ does not provide free money but rather credit facilities designed for active women entrepreneurs. To qualify, businesses must be registered as sole proprietorships headed by women, companies with at least 51% female shareholding, partnerships led by women, or formal/informal savings groups composed entirely of women. Applicants are also required to have an operational account with Stanbic Bank for at least six months, which eases qualification without the need for audited books.

Prof. Sarah Ssali, Head of the Institute of Gender and Development Studies, reaffirmed Makerere University’s commitment to gender equity and justice as central pillars of its operations. She noted that Makerere is the first public institution globally to apply for the UNDP’s Gender Equality Seal, with the process beginning in 2022. As part of this commitment, the university is evaluated on gender parity in student enrollment. Since 1991, initiatives such as the 1.5 scheme, the establishment of a gender institute, and other affirmative action programs, including those addressing disability and inclusion, have been implemented to promote gender balance among students.

She added that as a gender-responsive employer, the university emphasizes women’s representation in its workforce, particularly in leadership and staffing. Makerere has a comprehensive Gender Equality Policy and Framework supported by affirmative action, which has significantly increased women’s representation in both employment and leadership roles. However, Prof. Ssali acknowledged that challenges persist in the area of procurement. Bound by the PPDA Act, the university cannot impose gender quotas since bidding is based on merit and fair competition. Low participation of women in bids is often due to their operation at a micro-level, lack of familiarity with the PPDA Act, and insufficient capital to handle large contracts.

To address these challenges, Prof. Ssali said Makerere is exploring lawful strategies to promote gender parity in procurement. The main focus is to strengthen women-owned businesses so they can compete effectively for large contracts, while also supporting small and medium women entrepreneurs as they scale up. She explained that the current workshop was deliberately designed for women in business, with participation restricted to women-owned companies. Its primary goal was to build competitiveness by equipping participants with knowledge of pre-qualification, bid submission, assessment, appraisal, and selection processes—ensuring women-owned businesses are fully integrated into Makerere’s procurement activities as part of the university’s broader gender inclusivity agenda.

Ms. Sara Nakibuuka, a practicing procurement professional at Makerere University, stressed the importance of such initiatives in supporting women entrepreneurs. She encouraged women to take full advantage of provisions under the existing Acts of Parliament to expand their business opportunities and strengthen their market presence.

The Women in Business Training 2025 was moderated by Donna Keirungi, a member of the Makerere University Gender Equality Seal implementation team.

Eve Nakyanzi
Eve Nakyanzi

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E-Mobility Skilling Programme: Cohort 2 Applications Now Open!

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E-Mobility Skilling Programme: Cohort 2, in partnership with Kiira Motors Corporation and UNDP Uganda launched! Apply by September 1, 2025. Makerere University, Kampala Uganda, East Africa.

The Makerere University Innovation Pod is thrilled to announce the launch of the E-Mobility Skilling Programme: Cohort 2, in partnership with Kiira Motors Corporation and UNDP Uganda! This immersive one-year program offers exceptional Bachelor of Science and related discipline students (2nd-3rd year) the opportunity to gain cutting-edge skills in electric vehicle technology.

We are seeking motivated individuals from Physics, various Engineering fields, Industrial Art, Architecture, and Business (Marketing) with a strong academic record. Participants will engage in hands-on training, industrial immersion at Kiira Motors, and contribute to the development of the “Moonshot Project.”

Apply by September 1, 2025, to be part of this transformative skilling initiative. Female students are strongly encouraged to apply.

Learn more and apply here: https://forms.gle/jntp2TrzYqJ4TrKv9

Mak Editor

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Bid Notice: Refugee Law Project Mid-Term Review

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An aerial view of Left to Right: Mitchell Hall, Senate, CoCIS Blocks B and A, Lincoln Flats, Frank Kalimuzo Central Teaching Facility and School of Social Sciences (white) Buildings, Makerere University, with Kampala City in the background, October 2018. Uganda.

DETAILED BID NOTICE UNDER OPEN BIDDING

Invitation to bid for Consultancy Services for Midterm Review of The Embassy of The Kingdom of Netherlands Funded Project; Securing Refugee-Host Relations Through Enhanced Protection, under Refugee Law Project, School of Law, Makerere University.
Proc. Ref. No. MAK/SRVCS/2025-26/00013

  1. The Makerere University under Refugee Law Project has allocated funds to be used for the acquisition of Consultancy Services for Midterm Review of The Embassy of The Kingdom of Netherlands Funded Project; Securing Refugee-Host Relations Through Enhanced Protection, under Refugee Law Project, School of Law, Makerere University.
  2. The Entity invites sealed bids from eligible bidders for the provision of the above consultancy services.
  3. Bidding will be conducted in accordance with the open domestic bidding procedures contained in the Public Procurement and Disposal of Public Assets Act, 2003, and is open to all bidders.
  4. Interested eligible bidders may obtain further information and inspect the bidding documents at the address given below at 8(a) from 8:00am to 5:00pm.
  5. The Bidding Documents in English may be purchased by interested bidders on the submission of a written application to the address at 2 above and upon payment of a non-refundable fee of UGX. 100,000/= (One Hundred Thousand), only. The method of payment shall be cash payment after downloading Application Advice Slip from https://payments.mak.ac.ug/ and thereafter obtain a receipt from the bank before picking the document.
  6. Proposals must be delivered to the address below at 8(c) at or before 10:00am on Wednesday 20th August 2025. All proposals must be accompanied by a proposal securing declaration which must be valid until 28th February 2026. Late proposals shall be rejected. Proposals will be opened in the presence of the consultants’ representatives who choose to attend at the address below at 8(a) at 10:15am on 20th August 2025.

See below for detailed bid notice.

Mak Editor

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