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Mak 70th Grad PhD Citations Session 1, Part 3

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College of Health Sciences (CHS)

 

BBOSA Nicholas

A molecular phylogenetic and modelling approach towards understanding the transmission dynamics and genetic diversity of HIV-1 in the fishing communities of Lake Victoria, Uganda

Dr. BBOSA Nicholas used molecular phylogenetic and modelling approaches to dissect the transmission dynamics of HIV in the fishing communities of Lake Victoria. The fishing communities are disproportionately affected by HIV relative to the general population and for a long time, the dynamics of HIV transmission were not well understood. His research revealed for the first time in Uganda that the fishing communities were a sink for HIV transmission from the general population and negated the generally held assumption of the fishing communities being viral reservoirs. The findings have contributed towards informing public health policies on the implementation of targeted interventions for effective HIV epidemic control in most at-risk populations. This study was funded by the UK Medical research council, and was supervised by Prof. Pontiano Kaleebu, Prof. Andrew Leigh-Brown, Dr. Bernard S. Bagaya, Assoc. Prof Noah Kiwanuka and Dr. Rebecca N. Nsubuga.

 

BWIRE Godfrey

Molecular characterization and rapid detection of Vibrio cholerae in Uganda: the relationship between human pathogens and aquatic environment.

Dr. BWIRE Godfrey studied Vibrio cholerae, the bacteria responsible for repeated cholera outbreaks in Uganda to determine their genetic profile, spread, transmission, virulence, aquatic environmental reservoirs and a field cholera rapid diagnostic test (RDT). The study found that cholera outbreaks in Uganda were due to three genetically related V. cholerae clones. The clones showed transmission within Uganda, East and Central African regions. The surface water sources in Uganda were possibly not reservoirs for the epidemic V. cholerae. The accuracy of the cholera RDT, a modified Crystal VC® dipsticks was high. This study enhances our understanding of cholera outbreaks and may help in prevention, control and elimination of cholera in Uganda. The study was jointly funded by the Uganda Ministry of Health and Bill and Melinda Gates Foundation (USA) and supervised by Prof. Christopher Garimoi Orach (MakSPH) and Prof. David Allen Sack (John Hopkins University, USA).

 

EGESA Moses

Human B and T cell responses to novel Schistosoma mansoni skin-stage antigens

Mr. EGESA Moses studied human immune responses to parasite components expressed at the vulnerable skin larva stage of the human blood fluke, Schistosoma. It was not known how endemic populations respond to recombinant components of the larvae and how these immune responses relate with intensity of infection when people get re-infected. The recombinant antigens induced inflammatory cytokine responses. Additionally, antibodies to these antigens were detectable and were affected by treatment. Although not associated with reinfection intensity, the information generated informs the selection and prioritization of vaccine targets. This study was funded by a Wellcome Trust Strategic Award and the DELTAS Africa Initiative and supported by European Commission’s Seventh Framework Programme, and was supervised by Dr. Bernard Bagaya, Prof. Maria Yazdanbakhsh and Dr. Stephen Cose.

 

KADDUMUKASA Martin

Sodium intake in post-stroke patients – its influence on blood pressure, knowledge and perceptions and stroke outcomes in Uganda

Dr. KADDUMUKASA Martin’s thesis focuses on salt intake and cardiovascular stroke. He estimates the daily intake and its association with blood pressure and stroke. He further investigates knowledge, perceptions, and consumption decisions after stroke. He uses 24-hour urine to determine the salt intake in stroke patients. He notes that stroke survivors with high blood pressure have twice the levels of salt compared to stroke survivors without blood pressure. Poor knowledge, perceptions, and salt use beliefs. Finally, a high frequency of stroke recurrence and death was observed in this group. This study recommends primary stroke prevention through salt intake reduction and population salt awareness through education. This study was supported by NIH MEPI-linked Neurology Award (No. 5R24TW008886), Fogarty International Centre and was supervised by Prof. E. Katabira, Prof. Martha Sajatovic, Prof. Larry Goldstein and Dr. Pundik.

 

KAYIMA James

Hypertension in Uganda: epidemiology and association with HIV infection and genetics

Dr. KAYIMA James investigated the association of HIV infection and selected genes with blood pressure traits among Ugandans. He observed that, unlike the western populations, the frequency of hypertension was lower among HIV-infected compared to uninfected subjects in Uganda. Further, he uncovered the profound negative effect of SUB/NPR3 gene on systolic blood pressure. These finding suggest a protective effect of HIV on hypertension; and a potential modifying effect of SUB/NPR3 gene on hypertension in African populations. This work elucidates the role of HIV and population-specific genetic factors in the control of hypertension risk. It builds a foundation for formulation of prevention efforts for cardiovascular disease among high-risk groups; and for pharmacogenetic studies to identify appropriate medication for hypertensive black populations. This study was funded by Medical Education Partnership Initiative on Cardiovascular Disease (MEPI-CVD), and was supervised by Dr. Achilles Katamba, Prof. Harriet Mayanja Kizza, Prof. Xiaofeng Zhu and Prof. Mahboob Rahman.

 

MBOOWA Gerald

Functional host-genetic loci associated with pediatric HIV-disease progression in Uganda and Botswana

Dr. MBOOWA Gerald used genomics and bioinformatics approaches to identify a set of genes that informs us which person if HIV-infected will take many years to develop AIDS (symptoms) without HIV-treatment. His research revealed that following HIV infection, there are two groups of people; Rapid-AIDS progressors (develop symptoms in 3-years or less after infection) and Long-term non-progressors (>10-years to develop symptoms) without HIV-treatment. These findings have implications for the current “Test-and-Treat and Treat-for-Life” HIV-treatment policy; when one tests HIV-positive and started on treatment-for-life exposing them to drugs’ dangerous side-effects yet some HIV-infected people have nature ability to stay for many years without developing symptoms in absence of HIV-treatment. This study was funded by the Collaborative African Genomics Network-(CAfGEN) and Training Health Researchers into Vocational Excellence in East Africa-(THRiVE-2), and supervised by Prof Moses Joloba and Dr. David Kateete.

 

MPIMBAZA Arthur Mwambari

Determinants of severe malaria among children hospitalised at Jinja Regional Referral Hospital, Uganda

Dr. MPIMBAZA Arthur Mwambari studied determinants of severe malaria among children in the Busoga sub-region. Risk factors for severe malaria included delayed care seeking by more than 24 hours after fever onset and seeking care at a drug shop as the initial response. For convenience, drug shops were the most common provider sought by caregivers of children with severe malaria. However, drug shops offered sub-optimal healthcare services compared to public health facilities. Hemoglobin S heterozygotes, alpha thalassemia heterozygosity and homozygosity were associated with protection against severe malaria. Drug shops were a problem, contributing to delay and severe malaria. The role of drug shops in caring for children with malaria needs to be re-evaluated and services at public health facilities strengthened. This study was funded by NIH Fogarty International Center (TW009343 and TW007375) and was supervised by Assoc. Prof. Charles Karamagi, Prof. Anne Katahoire, Grace Ndeezi and Philip J Rosenthal.

 

NABATANZI Rose (Ms)

Innate immune system recovery after long-term antiretroviral therapy in an African cohort

Dr. NABATANZI Rose studied whether key blood cell populations of HIV infected adults recover completely after at least seven years of treatment with antiretroviral therapy (ART). This research found that despite at least seven years of effective ART, key first line defence cells among HIV-infected individuals were still fewer and produced low chemical mediators of first line defence against invading germs; compared with age-matched healthy HIV uninfected individuals. More emphasis should be put on ways of improving the body’s defence system for individuals on long-term ART to levels comparable to HIV-uninfected individuals, to prevent or delay HIV-associated complications among adults aging with the disease. This study was funded by DELTAS Africa Initiative, the Wellcome Trust and UK government and Alliance for Global Health and Science at University of California, Berkeley, USA; and was supervised by Prof. Damalie Nakanjako, Prof. Moses Joloba, Prof. Stephen Cose and Prof. Sarah Rowland Jones.

 

NAJJUKA Christine Florence (Ms)

Characterisation of extended spectrum Beta lactamases elaborated in Enterobactereaceae in Uganda

Dr. NAJJUKA Christine Florence investigated the prevalence of Extended Spectrum beta-Lactamases (ESBLs), the factors associated with gastrointestinal carriage, genotypes, transmission dynamics and co-resistance among clients attending outpatient clinics in Kampala, Kayunga and Mpigi Districts. She found predominance of cefotaximase in Kampala and presence of plasmid-mediated AmpC beta-lactamase genes, especially in ceftriaxone-susceptible Escherichia coli. Use of ciprofloxacin, inoculation and routine health follow up were risk factors, while rural residency and visiting lower health centres were protective of carriage of resistant bacteria. Transmission was predominantly by horizontal gene transfer of cefotaximase with at least two non-beta-lactam resistance genes. The findings inform widespread gut colonisation by bacteria resistant to 3rd generation cephalosporins and commonly used non beta-lactam agents, a source for transmission and infection with unpredictable and limited treatment options. This study was funded by Sida-Makerere Bilateral Research Programme and the Carnegie Cooperation of New York, and was supervised by Prof. Moses L. Joloba and Prof. Sabiha Y. Essack.

 

ZIDA Andre

Creating and institutionalizing supports for evidence-informed decision making, including a rapid response service, in the Burkina Faso health system

Dr. ZIDA Andre’s research focused on decision making in the Burkina Faso health system. His investigation focused on the institutionalization of a policy support unit called rapid response to provide evidence for urgent decision-making. The study showed that the institutionalization of decision support units demands a robust framework and political will. It can be non-linear, and it depends on the leadership of unit managers to implement relevant activities, mobilize funding, and recruit and maintain sufficient human resources. This study developed a clear roadmap for evidence-informed decision-making and policy unit institutionalization. This study was funded by International Development Research Centre (IDRC) and the European Union, and was supervised by Prof. Nelson K. Sewankambo, John N. Lavis and Dr. Bocar Kouyate.

 

Please click the links below to navigate to the PhD Citations for the respective Sessions.

< Director’s Message | Session 1: Part1 : Part2 : Part3 | Session 2 | Session 3 | Session 4 >

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Mark Wamai

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Makerere University Leaders Call for Excellence in Research and Supervision as Academic Staff and PhD Students Receive Certificates

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Prof. Sarah Ssali (Centre) flanked by Prof. Julius Kikooma (Left) and Dr. Dorothy Sebbowa Kyagaba (Right) at the certificate award ceremony on 15th December 2025. Graduate Supervision and Mentorship Course and PhD Students who successfully undertook the University’s compulsory cross-cutting doctoral courses Certificate Award Ceremony, Yusuf Lule Central Teaching Facility Auditorium, 15 December, 2025, Makerere University, Kampala Uganda, East Africa.

By Moses Lutaaya

Kampala, 15 December 2025Makerere University on Monday held a reflective and inspiring Certificate Award Ceremony at the CTF 2 Auditorium , Yusuf Lule to award academic staff who completed the Graduate Supervision and Mentorship Course and PhD Students who successfully undertook the University’s compulsory cross-cutting doctoral courses. The event was presided over by the Deputy Vice Chancellor – Academic Affairs, Prof. Sarah Ssali.

The ceremony honored the efforts and achievements of 58 academic staff members, 39 men and 19 women from various colleges including CEDAT, CAES, CEES, COVAB and COBAMS, who completed a rigorous three-week Graduate Supervision and Mentorship programme.

Additionally, PhD students were recognized for completing cross-cutting courses in Philosophy of Methods, Scholarly Writing and Communication, and Advanced Research Methods.

Left to Right: Prof. Julius Kikooma, Prof. Sarah Ssali and Dr. Dorothy Sebbowa Kyagaba follow proceedings. Graduate Supervision and Mentorship Course and PhD Students who successfully undertook the University’s compulsory cross-cutting doctoral courses Certificate Award Ceremony, Yusuf Lule Central Teaching Facility Auditorium, 15 December, 2025, Makerere University, Kampala Uganda, East Africa.
Left to Right: Prof. Julius Kikooma, Prof. Sarah Ssali and Dr. Dorothy Sebbowa Kyagaba follow proceedings.

In her keynote remarks, Prof. Sarah Ssali, the Deputy Vice Chancellor–Academic Affairs, delivered a message of encouragement and renewed commitment to research excellence at Makerere University.

“It is both an honor and a privilege to be here today to celebrate a significant academic milestone, the completion of the PhD Cross-Cutting Courses by our students and the award of Supervision Certificates to our academic staff.”

“Your completion of this course is not just a personal achievement, but a critical contribution to strengthening the research and mentoring capacity of Makerere University.”

To the PhD students, Prof. Ssali offered warm congratulations and encouragement. “These courses have equipped you with essential tools to conduct high-quality, ethical research and to engage with complex academic questions. This achievement reflects your hard work, intellectual growth, and commitment to excellence.”

She reaffirmed Makerere University’s commitment to research advancement. “As a University, we remain deeply committed to fostering a culture of research excellence. We will continue to invest in both our students and our staff, ensuring that we uphold the highest standards in research and academic supervision.”

The Director of Graduate Training, Prof. Julius Kikooma, challenged the PhD students to approach research with urgency, intentionality, and a clear sense of purpose.

Prof. Julius Kikooma, Director of Graduate Training. Graduate Supervision and Mentorship Course and PhD Students who successfully undertook the University’s compulsory cross-cutting doctoral courses Certificate Award Ceremony, Yusuf Lule Central Teaching Facility Auditorium, 15 December, 2025, Makerere University, Kampala Uganda, East Africa.
Prof. Julius Kikooma, the Director of Graduate Training.

 “Completing the crosscutting courses in Philosophy of Methods, Advanced Research Methods, and Scholarly Writing and Communication has not been an easy task. However, the certificate alone is not the end goal. Don’t simply compile these certificates. Make them meaningful.”

Prof. Kikooma emphasized that the value of the courses lies in applying the knowledge gained. “These certificates give you the foundation knowledge. The question now is: Can we see the application of that knowledge in your different fields?”

He further urged doctoral students to begin producing serious academic work now, not at the end of their studies. “If you are becoming someone to be listened to, start now. It means the course is becoming useful. Write about issues that speak to societal challenges. Produce thinking pieces. Produce better outputs. “Look for low-lying fruits that can make your PhD journey more exciting and impactful.”

 Prof. Kikooma also reminded students that while the PhD journey is shared by the academic community, its weight is uniquely felt by the candidates. “Your PhD journey is ours as a group. But you feel the heat. Speak to us so we understand your challenges. “You cannot be here for more than three years. Why are some of you still here? Is the journey heavy? How can we support you to complete it?” He asked.

He encouraged students to build thought leadership through the PhD Forum, adding that the forum is a strong voice for the students. A PhD is automatic leadership in the knowledge domain. Why doesn’t the PhD Forum come up with periodic writings that reflect what communities are experiencing? Start now so that by the time you finish the course, you hit the ground running.”

The Ag. Director of the Centre for Teaching and Learning Support (CTLS), Dr. Dorothy Ssebowa Kyagaba, gave a message to the academic staff who completed the Graduate Supervision and Mentorship Course, speaking with admiration for their dedication and high level of engagement.

Dr. Dorothy Sebbowa Kyagaba, the Ag. Director of the Center for Teaching and Learning Support (CTLS). Graduate Supervision and Mentorship Course and PhD Students who successfully undertook the University’s compulsory cross-cutting doctoral courses Certificate Award Ceremony, Yusuf Lule Central Teaching Facility Auditorium, 15 December, 2025, Makerere University, Kampala Uganda, East Africa.
Dr. Dorothy Sebbowa Kyagaba, the Ag. Director of the Center for Teaching and Learning Support (CTLS).

 “I congratulate all the academic staff who have completed the three-week Graduate Supervision and Mentorship Course. Your commitment, hard work, and enthusiasm have been evident throughout the training.”

She described the course as a cornerstone of Makerere’s commitment to strengthening graduate supervision. “This course is a key component in Makerere University’s drive to strengthen the quality of graduate training, research supervision, innovation, and strategic partnerships.”

She highlighted the thematic richness of the training; covering Knowledge Production Perspectives, Supervisory styles, Supervisory meetings and conversation skills, Research Ethics, Intercultural supervision and diversity, Scholarly writing and feedback as well as Examination processes and Doctoral Viva. She expressed gratitude to the Directorate of Graduate Training led by Prof. Kikooma, and to Prof. Ssali for providing leadership that advances graduate training across Makerere University.

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US$ 162m KEXIM Loan Approval Timely for Makerere University

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Front View of the reconstructed Main Building, Makerere University. Date Taken 8th November 2024. Kampala Uganda, East Africa.

The approval by the Parliament of Uganda of a US$162 million concessional loan from the Korea Export-Import Bank (KEXIM) on 16th December 2025 marks a pivotal moment for Makerere University, as the institution enters the fourth year of its second century of existence. This funding approval comes at a critical moment as the university underscores its intention to become research-intensive, against the pressing need to align with global standards in science, technology, engineering, and mathematics (STEM) education.

With student numbers growing from 5,000 three decades ago to approximately 35,000 today, Makerere‘s facilities continue to be stretched. The loan’s timely approval during a plenary session chaired by Deputy Speaker Rt. Hon. Thomas Tayebwa, underscores the government’s commitment to revitalizing higher education amid national development goals outlined in the National Development Plan IV and the Ten-fold Growth Strategy.

Anticipated Developments

The loan will finance the construction of a state-of-the-art science and technology center, complete with advanced laboratories and innovation hubs for engineering disciplines. Upgrades to existing labs and smart classrooms at the College of Computing and Information Sciences are planned, alongside new buildings for Electrical, Civil and Mechanical Engineering Departments.

The College of Health Sciences will see expanded preclinical education facilities, and a dedicated structure for the School of Dentistry will incorporate cutting-edge equipment for dental technology, education, and clinical practice. These initiatives are not mere expansions; they aim to elevate Makerere to international benchmarks, fostering an environment where students can engage in hands-on research and practical training.

Furthermore, capacity-building programs will empower staff to harness new technologies, ensuring sustainable operations long after the 42-month implementation period, spanning financial years 2025-2026 to 2029-2030. The timing couldn’t be more opportune. Uganda’s ratio of science and technology graduates to humanities remains at 2:5, a ratio the loan is anticipated to improve to least 3:5 by 2030.

The loan facility addresses immediate challenges like inadequate spaces for growing programs, such as the Bachelor of Medicine and Bachelor of Surgery, which has seen a rise in intake, with increased interest from international applicants. Additionally, by investing in PhD training at Makerere, the loan reduces reliance on costly overseas programs, enabling resources to be redirected toward comprehensive educational enhancements.

Government’s Broader Strategy

Makerere as the premier regional institution has been prioritized to receive funding based on Government’s recognition of the trickle-down effect that enhancing the capacity at the university has on other higher education institutions and the education ecosystem. This approval builds on Makerere‘s legacy of resilience, positioning it as a beacon for African innovation. In an era where technological advancement defines global progress, this loan propels Makerere toward producing graduates equipped to tackle real-world challenges, from climate resilience to digital transformation.

Ultimately, the KEXIM loan is a timely catalyst for Makerere‘s renaissance. It not only revamps physical infrastructure but also reignites the university’s role in socio-economic transformation, with the Ministry of Education and Sports (MoES) as the executing agency. Therefore, as Uganda eyes Ten-Fold Growth from approximately $50 billion (2023) to $500 billion by 2040 via Agro-industrialisation, Tourism, Mineral-based industrialisation, Science and Technology/ICT (ATMS), empowering Makerere University is not just strategic—it’s essential.

Taking Stock of Previous Support

The African Development Bank’s (AfDB) US$29.2 million under the HEST program in 2016 funded infrastructure at Makerere, including two centralised teaching facilities with lecture rooms, auditoriums, e-learning labs, and specialized facilities like diagnostic, biotechnology, GIS, and computer labs. These transformed the skyline, enhanced large-class teaching, research access, and service provision to a thriving staff and students’ community.

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Makerere University Hosts EU Delegation to Review Institutional Engagement in EU Cooperation Programmes

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Makerere University today hosted a delegation of members from the European Union (EU) for a high-level engagement aimed at reviewing the University’s involvement in EU cooperation programmes. The meeting focused on the linkages between the Erasmus+ Programme, Makerere University’s internationalization strategy, and the related institutional management and coordination structures.

The delegation was received by Deputy Vice Chancellor (Academic Affairs) Professor Sarah Ssali, provided an overview of how EU cooperation programmes are coordinated across different offices within the University. She highlighted Makerere’s integrated institutional approach to managing EU-funded initiatives, emphasizing collaboration among academic units, administrative offices, and support departments to ensure effective implementation and sustainability of projects.

Professor Sarah Ssali presenting to the delegation.

Prof. Sylivia Antonia Nakimera Nanyonga-Tamusuza presented an overview of how grants are handled at Makerere University, with particular emphasis on the role of the Grants Management and Support (GAMSU) Office. She explained that the office provides end-to-end support for externally funded projects, including proposal development, grant negotiation, compliance, financial accountability, reporting, and capacity building for project teams. The GAMSU Office plays a critical role in ensuring transparency, efficiency, and compliance with donor requirements, including those of the European Union.

Prof. Sylivia Antonia Nakimera Nanyonga-Tamusuza(R) interact with the delegation.

The University Secretary, Mr. Yusuf Kiranda, addressed the meeting and outlined how the University’s resources are managed to support academic programmes and international cooperation initiatives. He further explained the role of the Office of the University Secretary in supporting students, including policy oversight, governance, student welfare, administrative coordination, and ensuring that institutional systems effectively support teaching, research, and international partnerships.

Ms. Betty Nabisubi

Ms. Betty Nabisubi from the International Relations Office (IRO) provided a comprehensive overview of how Erasmus+ programmes are coordinated within her office. She explained that the IRO supports Erasmus students and staff from the time they arrive at Makerere University until their departure. This includes orientation, immigration support, accommodation guidance, academic coordination, cultural integration, and continuous student support. She also highlighted additional services offered by the office, such as partnership development, mobility coordination, and facilitation of international collaborations.

Following the institutional presentations, project representatives were allocated 30 minutes for structured discussions with EU project contact persons. The session began with short presentations focusing on project results, impact, and sustainability, followed by an interactive discussion and question-and-answer session. The representatives presented their projects clearly and confidently, demonstrating strong outcomes and long-term impact aligned with both Makerere University and EU cooperation objectives.

Overall, the engagement was highly productive and fruitful, providing a valuable platform for knowledge sharing, reflection on best practices, and strengthening collaboration between Makerere University and the European Union. The discussions reaffirmed Makerere University’s commitment to effective internationalization, accountable project management, and sustained partnerships under EU cooperation programmes.

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