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Mak 70th Grad PhD Citations Session 1, Part 3

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College of Health Sciences (CHS)

 

BBOSA Nicholas

A molecular phylogenetic and modelling approach towards understanding the transmission dynamics and genetic diversity of HIV-1 in the fishing communities of Lake Victoria, Uganda

Dr. BBOSA Nicholas used molecular phylogenetic and modelling approaches to dissect the transmission dynamics of HIV in the fishing communities of Lake Victoria. The fishing communities are disproportionately affected by HIV relative to the general population and for a long time, the dynamics of HIV transmission were not well understood. His research revealed for the first time in Uganda that the fishing communities were a sink for HIV transmission from the general population and negated the generally held assumption of the fishing communities being viral reservoirs. The findings have contributed towards informing public health policies on the implementation of targeted interventions for effective HIV epidemic control in most at-risk populations. This study was funded by the UK Medical research council, and was supervised by Prof. Pontiano Kaleebu, Prof. Andrew Leigh-Brown, Dr. Bernard S. Bagaya, Assoc. Prof Noah Kiwanuka and Dr. Rebecca N. Nsubuga.

 

BWIRE Godfrey

Molecular characterization and rapid detection of Vibrio cholerae in Uganda: the relationship between human pathogens and aquatic environment.

Dr. BWIRE Godfrey studied Vibrio cholerae, the bacteria responsible for repeated cholera outbreaks in Uganda to determine their genetic profile, spread, transmission, virulence, aquatic environmental reservoirs and a field cholera rapid diagnostic test (RDT). The study found that cholera outbreaks in Uganda were due to three genetically related V. cholerae clones. The clones showed transmission within Uganda, East and Central African regions. The surface water sources in Uganda were possibly not reservoirs for the epidemic V. cholerae. The accuracy of the cholera RDT, a modified Crystal VC® dipsticks was high. This study enhances our understanding of cholera outbreaks and may help in prevention, control and elimination of cholera in Uganda. The study was jointly funded by the Uganda Ministry of Health and Bill and Melinda Gates Foundation (USA) and supervised by Prof. Christopher Garimoi Orach (MakSPH) and Prof. David Allen Sack (John Hopkins University, USA).

 

EGESA Moses

Human B and T cell responses to novel Schistosoma mansoni skin-stage antigens

Mr. EGESA Moses studied human immune responses to parasite components expressed at the vulnerable skin larva stage of the human blood fluke, Schistosoma. It was not known how endemic populations respond to recombinant components of the larvae and how these immune responses relate with intensity of infection when people get re-infected. The recombinant antigens induced inflammatory cytokine responses. Additionally, antibodies to these antigens were detectable and were affected by treatment. Although not associated with reinfection intensity, the information generated informs the selection and prioritization of vaccine targets. This study was funded by a Wellcome Trust Strategic Award and the DELTAS Africa Initiative and supported by European Commission’s Seventh Framework Programme, and was supervised by Dr. Bernard Bagaya, Prof. Maria Yazdanbakhsh and Dr. Stephen Cose.

 

KADDUMUKASA Martin

Sodium intake in post-stroke patients – its influence on blood pressure, knowledge and perceptions and stroke outcomes in Uganda

Dr. KADDUMUKASA Martin’s thesis focuses on salt intake and cardiovascular stroke. He estimates the daily intake and its association with blood pressure and stroke. He further investigates knowledge, perceptions, and consumption decisions after stroke. He uses 24-hour urine to determine the salt intake in stroke patients. He notes that stroke survivors with high blood pressure have twice the levels of salt compared to stroke survivors without blood pressure. Poor knowledge, perceptions, and salt use beliefs. Finally, a high frequency of stroke recurrence and death was observed in this group. This study recommends primary stroke prevention through salt intake reduction and population salt awareness through education. This study was supported by NIH MEPI-linked Neurology Award (No. 5R24TW008886), Fogarty International Centre and was supervised by Prof. E. Katabira, Prof. Martha Sajatovic, Prof. Larry Goldstein and Dr. Pundik.

 

KAYIMA James

Hypertension in Uganda: epidemiology and association with HIV infection and genetics

Dr. KAYIMA James investigated the association of HIV infection and selected genes with blood pressure traits among Ugandans. He observed that, unlike the western populations, the frequency of hypertension was lower among HIV-infected compared to uninfected subjects in Uganda. Further, he uncovered the profound negative effect of SUB/NPR3 gene on systolic blood pressure. These finding suggest a protective effect of HIV on hypertension; and a potential modifying effect of SUB/NPR3 gene on hypertension in African populations. This work elucidates the role of HIV and population-specific genetic factors in the control of hypertension risk. It builds a foundation for formulation of prevention efforts for cardiovascular disease among high-risk groups; and for pharmacogenetic studies to identify appropriate medication for hypertensive black populations. This study was funded by Medical Education Partnership Initiative on Cardiovascular Disease (MEPI-CVD), and was supervised by Dr. Achilles Katamba, Prof. Harriet Mayanja Kizza, Prof. Xiaofeng Zhu and Prof. Mahboob Rahman.

 

MBOOWA Gerald

Functional host-genetic loci associated with pediatric HIV-disease progression in Uganda and Botswana

Dr. MBOOWA Gerald used genomics and bioinformatics approaches to identify a set of genes that informs us which person if HIV-infected will take many years to develop AIDS (symptoms) without HIV-treatment. His research revealed that following HIV infection, there are two groups of people; Rapid-AIDS progressors (develop symptoms in 3-years or less after infection) and Long-term non-progressors (>10-years to develop symptoms) without HIV-treatment. These findings have implications for the current “Test-and-Treat and Treat-for-Life” HIV-treatment policy; when one tests HIV-positive and started on treatment-for-life exposing them to drugs’ dangerous side-effects yet some HIV-infected people have nature ability to stay for many years without developing symptoms in absence of HIV-treatment. This study was funded by the Collaborative African Genomics Network-(CAfGEN) and Training Health Researchers into Vocational Excellence in East Africa-(THRiVE-2), and supervised by Prof Moses Joloba and Dr. David Kateete.

 

MPIMBAZA Arthur Mwambari

Determinants of severe malaria among children hospitalised at Jinja Regional Referral Hospital, Uganda

Dr. MPIMBAZA Arthur Mwambari studied determinants of severe malaria among children in the Busoga sub-region. Risk factors for severe malaria included delayed care seeking by more than 24 hours after fever onset and seeking care at a drug shop as the initial response. For convenience, drug shops were the most common provider sought by caregivers of children with severe malaria. However, drug shops offered sub-optimal healthcare services compared to public health facilities. Hemoglobin S heterozygotes, alpha thalassemia heterozygosity and homozygosity were associated with protection against severe malaria. Drug shops were a problem, contributing to delay and severe malaria. The role of drug shops in caring for children with malaria needs to be re-evaluated and services at public health facilities strengthened. This study was funded by NIH Fogarty International Center (TW009343 and TW007375) and was supervised by Assoc. Prof. Charles Karamagi, Prof. Anne Katahoire, Grace Ndeezi and Philip J Rosenthal.

 

NABATANZI Rose (Ms)

Innate immune system recovery after long-term antiretroviral therapy in an African cohort

Dr. NABATANZI Rose studied whether key blood cell populations of HIV infected adults recover completely after at least seven years of treatment with antiretroviral therapy (ART). This research found that despite at least seven years of effective ART, key first line defence cells among HIV-infected individuals were still fewer and produced low chemical mediators of first line defence against invading germs; compared with age-matched healthy HIV uninfected individuals. More emphasis should be put on ways of improving the body’s defence system for individuals on long-term ART to levels comparable to HIV-uninfected individuals, to prevent or delay HIV-associated complications among adults aging with the disease. This study was funded by DELTAS Africa Initiative, the Wellcome Trust and UK government and Alliance for Global Health and Science at University of California, Berkeley, USA; and was supervised by Prof. Damalie Nakanjako, Prof. Moses Joloba, Prof. Stephen Cose and Prof. Sarah Rowland Jones.

 

NAJJUKA Christine Florence (Ms)

Characterisation of extended spectrum Beta lactamases elaborated in Enterobactereaceae in Uganda

Dr. NAJJUKA Christine Florence investigated the prevalence of Extended Spectrum beta-Lactamases (ESBLs), the factors associated with gastrointestinal carriage, genotypes, transmission dynamics and co-resistance among clients attending outpatient clinics in Kampala, Kayunga and Mpigi Districts. She found predominance of cefotaximase in Kampala and presence of plasmid-mediated AmpC beta-lactamase genes, especially in ceftriaxone-susceptible Escherichia coli. Use of ciprofloxacin, inoculation and routine health follow up were risk factors, while rural residency and visiting lower health centres were protective of carriage of resistant bacteria. Transmission was predominantly by horizontal gene transfer of cefotaximase with at least two non-beta-lactam resistance genes. The findings inform widespread gut colonisation by bacteria resistant to 3rd generation cephalosporins and commonly used non beta-lactam agents, a source for transmission and infection with unpredictable and limited treatment options. This study was funded by Sida-Makerere Bilateral Research Programme and the Carnegie Cooperation of New York, and was supervised by Prof. Moses L. Joloba and Prof. Sabiha Y. Essack.

 

ZIDA Andre

Creating and institutionalizing supports for evidence-informed decision making, including a rapid response service, in the Burkina Faso health system

Dr. ZIDA Andre’s research focused on decision making in the Burkina Faso health system. His investigation focused on the institutionalization of a policy support unit called rapid response to provide evidence for urgent decision-making. The study showed that the institutionalization of decision support units demands a robust framework and political will. It can be non-linear, and it depends on the leadership of unit managers to implement relevant activities, mobilize funding, and recruit and maintain sufficient human resources. This study developed a clear roadmap for evidence-informed decision-making and policy unit institutionalization. This study was funded by International Development Research Centre (IDRC) and the European Union, and was supervised by Prof. Nelson K. Sewankambo, John N. Lavis and Dr. Bocar Kouyate.

 

Please click the links below to navigate to the PhD Citations for the respective Sessions.

< Director’s Message | Session 1: Part1 : Part2 : Part3 | Session 2 | Session 3 | Session 4 >

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Mark Wamai

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Makerere University Pushes for Stronger Support for Research Ethics Committees amid Growing Research Demands

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Seated: Prof. Sarah Ssali (2nd L) and Prof. Robert Wamala (2nd R) with Chairpersons of Research Ethics Committees on 25th May 2026. High-level meeting between University Management and Chairpersons of Research Ethics Committees (RECs) held in the Vice Chancellor’s Boardroom, Makerere University Main building, Kampala Uganda, East Africa on May 25, 2026.

By Moses Lutaaya

Makerere University has intensified efforts to strengthen research governance and ethical oversight, with university leaders calling for greater institutional support for Research Ethics Committees (RECs), whose role has become increasingly central to the institution’s research-led agenda.

The call was made during a high-level meeting between University Management and Chairpersons of Research Ethics Committees held at the Vice Chancellor’s Boardroom at the Makerere University Main Building on May 25, 2026.

Opening the meeting, the Director of Research Innovations and Partnerships (DRIP), Prof. Robert Wamala, highlighted a number of operational and administrative challenges affecting the effectiveness of RECs at Makerere University.

Prof. Wamala observed that RECs continue to operate with gaps in institutional framework outlining their position within the university governance structure, a gap he said has affected institutional support and long-term sustainability.

According to Prof. Wamala, inadequate facilitation continues to affect the operations of several committees, especially in areas of staffing, administrative coordination, and remuneration for REC administrators.

Prof. Robert Wamala. High-level meeting between University Management and Chairpersons of Research Ethics Committees (RECs) held in the Vice Chancellor’s Boardroom, Makerere University Main building, Kampala Uganda, East Africa on May 25, 2026.
Prof. Robert Wamala.

He also pointed to challenges arising from new regulatory requirements governing the appointment of REC members, particularly the need for appointment letters to be authorized or signed by the Vice Chancellor.

Prof. Wamala further raised concern over the high cost of mandatory accreditation and training processes required by the Uganda National Council for Science and Technology (UNCST), especially the Good Research Regulatory Practice (GRRP) training undertaken every three years. “Payment for training is too high for individual RECs to cover,” he noted, adding that many committees are struggling to independently raise the money to undertake the training for all their members.

He also emphasized the need for stronger institutional monitoring systems to support timely submission of accreditation renewal applications, oversight of approved research activities, and coordination of REC operations across the university.

In her remarks, the Deputy Vice Chancellor in charge of Academic Affairs, Prof. Sarah Ssali, commended the growing contribution of RECs in advancing Makerere University’s research agenda and acknowledged the concerns raised by Prof. Wamala and committee members.

“There were not very many RECs,” Prof. Ssali said. “So now that we are 10, it is really impressive because it speaks to our cause for a research-led university.” She admitted that despite their importance, many RECs still operate outside the formal university establishment, making staffing and operational support difficult.

Prof. Sarah Ssali. High-level meeting between University Management and Chairpersons of Research Ethics Committees (RECs) held in the Vice Chancellor’s Boardroom, Makerere University Main building, Kampala Uganda, East Africa on May 25, 2026.
Prof. Sarah Ssali.

“The only challenge that I see is that they are not fully institutionalized. So it is upon units to start them or not to start them,” she explained. Prof. Ssali added that because RECs are not fully integrated into the public service structure of the university, recruiting and remunerating staff through conventional university systems remains complicated. “Hiring for them staff will be a little bit cumbersome because the university will say they are not part of our structure,” she said.

She nevertheless emphasized that university management recognizes the strategic importance of RECs in strengthening ethical research oversight and supporting Makerere’s position as a research-led institution. “RECs are doing a great job of furthering our strategic agenda of being a research-led university,” she noted.

Prof. Ssali explained that the growing reliance on institutional RECs by the Uganda National Council for Science and Technology demonstrates the trust placed in Makerere University’s ethical review systems.

Addressing concerns about the cost and frequency of mandatory training, Prof. Ssali acknowledged the financial burden on RECs but explained that many of the requirements are set by national regulators. “Many of the things you have raised are with National Council, they are not with us,” she said. “We can only pledge to lobby.”

To address logistical challenges associated with training senior academics, she proposed more flexible scheduling arrangements. “For a professor to give you a whole day is going to be a challenge,” she said. “Maybe you can do half days throughout the week.”

Prof. Ssali also encouraged colleges and schools to allocate part of their enhanced research budgets toward supporting REC activities, including staffing, training, and operational facilitation.

The High-Level Meeting in session. High-level meeting between University Management and Chairpersons of Research Ethics Committees (RECs) held in the Vice Chancellor’s Boardroom, Makerere University Main building, Kampala Uganda, East Africa on May 25, 2026.
The High-Level Meeting in session.

She suggested that colleges and schools hosting RECs should directly take responsibility for sustaining them. “For me, that’s the way out — to ensure that the colleges and schools that have RECs take them as their responsibility,” she noted.

The DVC-AA also addressed concerns related to intellectual property rights, Material Transfer Agreements (MTA), and the need for researchers to formally communicate scientific discoveries and innovations to the university to ensure institutional protection and benefit-sharing. “All you are saying is true, but it depends on you as researchers informing the institution that we have made this discovery,” she said.

Prof. Ssali reiterated Makerere University’s commitment to strengthening research governance systems and pledged continued engagement with both university management and national regulatory bodies to address the concerns raised by REC members. “Where they are, they enable research, publication and growth,” she said of the RECs. “Most importantly, they enable us to be ethical with the way we do our things.”

The meeting was attended by chairpersons of the various Research Ethics Committees across Makerere University and affiliated institutions. These included Dr. Ponsiano Ochama from the School of Medicine Research Ethics Committee (SOM-REC), Dr. Moses Ocan from the School of Biomedical Sciences Research Ethics Committee (SBS-REC), Dr. Paul Kutyabami from the School of Health Sciences Research Ethics Committee, Dr. David Kyaddondo from the Uganda Cancer Institute Research Ethics Committee, Dr. Stella Neema from the School of Social Sciences Research Ethics Committee (MAKSS-REC), Dr. Joseph Kagayi from the School of Public Health Research Ethics Committee, Dr. Joseph Kateete from the Infectious Diseases Institute Research Ethics Committee, Dr. Fred Okuku from the Uganda Heart Institute Research Ethics Committee, Dr. Kassim Sadik from the College of Agricultural and Environmental Sciences Research Ethics Committee, and Dr. Eddy Walakira from the College of Business and Management Sciences Research Ethics Committee.

The discussions reflected Makerere University’s broader ambition to consolidate its position as a leading research-intensive institution while ensuring that ethical standards, accountability, and innovation protection remain central to its academic mission.

Mak Editor

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Sylas Ruhweza: A Brief Life Marked by Meaningful Accomplishments

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The late Sylas Ruhweza, 3rd President of the Scholars Association Makerere University (SAMAK). Kampala Uganda, East Africa.

On May 29, 2026, the Mastercard Foundation Scholars Community learned of the passing of Sylas Ruhweza Atwooki, a remarkable Scholar of the Mastercard Foundation Scholars Program at Makerere University. At just 32 years old, Sylas had already made an indelible mark. He served as the representative of Makerere University on the Mastercard Foundation Advisory Board, contributing to vital decisions that shape the future. Additionally, he held the prestigious role of Minister of Information for Tooro Kingdom, an extraordinary achievement that set a powerful example for his peers and illuminated the potential for leadership and impact within the community.

Sylas was born on 19 July 1994 to the late Tinkasimire Paul Adyeeri and Ms. Ategeka Margret Abwooli in what is now Bunyangabu District. As the ninth of eleven children, he recognised early the power of education and the doors it can open. His academic journey commenced at Kaboyo Primary School, followed by Fort Portal Secondary School for his O-levels. With the backing of the Mastercard Foundation Scholarship, he confidently pursued his A-levels at Hannah International School and later enrolled at Makerere University, where he successfully earned a Bachelor of Science in Petroleum Geoscience and Production in 2022, once again bolstered by the Mastercard Foundation Scholars Program.

Sylas actively contributed to the Scholars community as the 3rd President of the Scholars Association Makerere University (SAMAK) and as the first Team Lead of the AlumNet Foundation, established in 2018, an umbrella organisation that unites all the alumni of the Mastercard Foundation at Makerere University. This organisation serves as a community of practice for Makerere University alumni, promoting agency and voice, peer mentorship, and community-impact initiatives. He demonstrated transformative leadership as Chairperson of the Mastercard Foundation Alumni Network at BRAC from 2020 to 2022. At the time of his death, Sylas served as the Minister of Information in the Tooro Kingdom and as the Strategy and Engagement Lead for the Mastercard Foundation Alumni Network’s Uganda Chapter, where he continued to advocate for collaboration and social responsibility. He was a Programme Associate at Africa Climate Collaborative, one of the Mastercard Foundation Initiatives at Makerere University, and was also pursuing his Master’s degree at Victoria University. May his soul find eternal peace.

Bernard Buteera is the Principal Communications and Public Relations Officer of the Mastercard Foundation Scholars Programme at Makerere University.

Bernard Buteera

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Makerere University Chancellor Dr. Crispus Kiyonga Appointed 2nd Deputy Prime Minister

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The Chancellor, Hon. Dr. Crispus Kiyonga gestures during an interview on 17th January 2025. 75th Graduation Ceremony, Day 5, CAES, CEDAT and CHUSS. 17th January 2025, Freedom Square, Makerere University, Kampala Uganda, East Africa.

President Yoweri Kaguta Museveni has appointed Makerere University Chancellor Dr. Crispus Walter Kiyonga as Uganda’s Second Deputy Prime Minister and Deputy Leader of Government Business in Parliament.

The appointment was announced on May 26, 2026, as part of the cabinet reshuffle for the 2026–2031 government term. Dr. Kiyonga now assumes one of the senior leadership positions in government while continuing to serve as Chancellor of Makerere University.

Dr. Kiyonga is both Chancellor and alumnus of Makerere University. He studied at Makerere University School of Medicine from 1973 to 1978, graduating with a Bachelor of Medicine and Bachelor of Surgery (MBChB). He later obtained a Master of Health Science in Population Dynamics from the Johns Hopkins School of Public Health in 2004.

Born on September 19, 1952, in Kasese District, Dr. Kiyonga attended Bwera Primary School, Nyakasura School, and Kings College Budo before joining Makerere University.

He was appointed Chancellor of Makerere University in August 2024 and formally installed in October 2024, succeeding Professor Ezra Suruma.

Incoming Chancellor Dr. Crispus Kiyonga lifting the Chancellor’s Mace.

Political and Public Service Career

Dr. Kiyonga entered national politics during Uganda’s 1980 elections, where he won a parliamentary seat on the Uganda Patriotic Movement (UPM) ticket. He later joined the National Resistance Movement during the liberation struggle and subsequently served in several senior government positions after 1986.

He represented Bukonjo County West in Parliament from 1980 to 2016 and was also a member of the Constituent Assembly that drafted the 1995 Constitution.

Over the years, Dr. Kiyonga has held several ministerial portfolios, including:

  • Minister for Cooperatives and Marketing
  • Minister of Finance
  • Minister of Internal Affairs
  • Minister of Health
  • Minister without Portfolio
  • Minister of Defence

During his tenure as Minister of Health, he played a key role in Uganda’s response to the Ebola outbreak in Gulu in 2000.

From 2016, he served as Uganda’s Ambassador to China, where he represented Uganda during a significant period of Uganda-China relations.

Dr. Kiyonga’s appointment marks a return to frontline government leadership after several years in diplomatic service and university leadership.

Significance for Makerere

As Chancellor, Dr. Kiyonga serves as the titular head of Makerere University and presides over major ceremonial functions, including graduation ceremonies.

University Chancellor Dr. Crispus Kiyonga confers a Doctorate Degree upon one of the graduands during the 76th Graduation Ceremony. 76th Graduation Ceremony, Day 2, School of Public Health (MakSPH). Commencement Speaker-Dr. Margaret J. Kigozi, Makerere University Endowment Fund Chairperson. 25th February 2026, Freedom Square, Kampala Uganda, East Africa.
University Chancellor Dr. Crispus Kiyonga confers a Doctorate Degree upon one of the graduands during the 76th Graduation Ceremony.

His appointment reflects the longstanding contribution of Makerere University alumni to public service and national leadership in Uganda and across the region.

Speaking during his installation as Chancellor in 2024, the First Lady and Minister of Education and Sports, Hon. Janet K. Museveni, noted that Dr. Kiyonga’s experience and networks would support the advancement of the university.

Makerere University congratulates Chancellor Dr. Crispus Walter Kiyonga upon his appointment and wishes him success in his new role.

The Writer is a Volunteer in the Public Relations Office, Makerere University and the Mak Sharks PRO | Est. 2014

Philemon Akoragye.
Philemon Akoragye

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