General
Mak 70th Grad PhD Citations Session 1, Part 3
Published
5 years agoon
College of Health Sciences (CHS)
BBOSA Nicholas
A molecular phylogenetic and modelling approach towards understanding the transmission dynamics and genetic diversity of HIV-1 in the fishing communities of Lake Victoria, Uganda
Dr. BBOSA Nicholas used molecular phylogenetic and modelling approaches to dissect the transmission dynamics of HIV in the fishing communities of Lake Victoria. The fishing communities are disproportionately affected by HIV relative to the general population and for a long time, the dynamics of HIV transmission were not well understood. His research revealed for the first time in Uganda that the fishing communities were a sink for HIV transmission from the general population and negated the generally held assumption of the fishing communities being viral reservoirs. The findings have contributed towards informing public health policies on the implementation of targeted interventions for effective HIV epidemic control in most at-risk populations. This study was funded by the UK Medical research council, and was supervised by Prof. Pontiano Kaleebu, Prof. Andrew Leigh-Brown, Dr. Bernard S. Bagaya, Assoc. Prof Noah Kiwanuka and Dr. Rebecca N. Nsubuga.
BWIRE Godfrey
Molecular characterization and rapid detection of Vibrio cholerae in Uganda: the relationship between human pathogens and aquatic environment.
Dr. BWIRE Godfrey studied Vibrio cholerae, the bacteria responsible for repeated cholera outbreaks in Uganda to determine their genetic profile, spread, transmission, virulence, aquatic environmental reservoirs and a field cholera rapid diagnostic test (RDT). The study found that cholera outbreaks in Uganda were due to three genetically related V. cholerae clones. The clones showed transmission within Uganda, East and Central African regions. The surface water sources in Uganda were possibly not reservoirs for the epidemic V. cholerae. The accuracy of the cholera RDT, a modified Crystal VC® dipsticks was high. This study enhances our understanding of cholera outbreaks and may help in prevention, control and elimination of cholera in Uganda. The study was jointly funded by the Uganda Ministry of Health and Bill and Melinda Gates Foundation (USA) and supervised by Prof. Christopher Garimoi Orach (MakSPH) and Prof. David Allen Sack (John Hopkins University, USA).
EGESA Moses
Human B and T cell responses to novel Schistosoma mansoni skin-stage antigens
Mr. EGESA Moses studied human immune responses to parasite components expressed at the vulnerable skin larva stage of the human blood fluke, Schistosoma. It was not known how endemic populations respond to recombinant components of the larvae and how these immune responses relate with intensity of infection when people get re-infected. The recombinant antigens induced inflammatory cytokine responses. Additionally, antibodies to these antigens were detectable and were affected by treatment. Although not associated with reinfection intensity, the information generated informs the selection and prioritization of vaccine targets. This study was funded by a Wellcome Trust Strategic Award and the DELTAS Africa Initiative and supported by European Commission’s Seventh Framework Programme, and was supervised by Dr. Bernard Bagaya, Prof. Maria Yazdanbakhsh and Dr. Stephen Cose.
KADDUMUKASA Martin
Sodium intake in post-stroke patients – its influence on blood pressure, knowledge and perceptions and stroke outcomes in Uganda
Dr. KADDUMUKASA Martin’s thesis focuses on salt intake and cardiovascular stroke. He estimates the daily intake and its association with blood pressure and stroke. He further investigates knowledge, perceptions, and consumption decisions after stroke. He uses 24-hour urine to determine the salt intake in stroke patients. He notes that stroke survivors with high blood pressure have twice the levels of salt compared to stroke survivors without blood pressure. Poor knowledge, perceptions, and salt use beliefs. Finally, a high frequency of stroke recurrence and death was observed in this group. This study recommends primary stroke prevention through salt intake reduction and population salt awareness through education. This study was supported by NIH MEPI-linked Neurology Award (No. 5R24TW008886), Fogarty International Centre and was supervised by Prof. E. Katabira, Prof. Martha Sajatovic, Prof. Larry Goldstein and Dr. Pundik.
KAYIMA James
Hypertension in Uganda: epidemiology and association with HIV infection and genetics
Dr. KAYIMA James investigated the association of HIV infection and selected genes with blood pressure traits among Ugandans. He observed that, unlike the western populations, the frequency of hypertension was lower among HIV-infected compared to uninfected subjects in Uganda. Further, he uncovered the profound negative effect of SUB/NPR3 gene on systolic blood pressure. These finding suggest a protective effect of HIV on hypertension; and a potential modifying effect of SUB/NPR3 gene on hypertension in African populations. This work elucidates the role of HIV and population-specific genetic factors in the control of hypertension risk. It builds a foundation for formulation of prevention efforts for cardiovascular disease among high-risk groups; and for pharmacogenetic studies to identify appropriate medication for hypertensive black populations. This study was funded by Medical Education Partnership Initiative on Cardiovascular Disease (MEPI-CVD), and was supervised by Dr. Achilles Katamba, Prof. Harriet Mayanja Kizza, Prof. Xiaofeng Zhu and Prof. Mahboob Rahman.
MBOOWA Gerald
Functional host-genetic loci associated with pediatric HIV-disease progression in Uganda and Botswana
Dr. MBOOWA Gerald used genomics and bioinformatics approaches to identify a set of genes that informs us which person if HIV-infected will take many years to develop AIDS (symptoms) without HIV-treatment. His research revealed that following HIV infection, there are two groups of people; Rapid-AIDS progressors (develop symptoms in 3-years or less after infection) and Long-term non-progressors (>10-years to develop symptoms) without HIV-treatment. These findings have implications for the current “Test-and-Treat and Treat-for-Life” HIV-treatment policy; when one tests HIV-positive and started on treatment-for-life exposing them to drugs’ dangerous side-effects yet some HIV-infected people have nature ability to stay for many years without developing symptoms in absence of HIV-treatment. This study was funded by the Collaborative African Genomics Network-(CAfGEN) and Training Health Researchers into Vocational Excellence in East Africa-(THRiVE-2), and supervised by Prof Moses Joloba and Dr. David Kateete.
MPIMBAZA Arthur Mwambari
Determinants of severe malaria among children hospitalised at Jinja Regional Referral Hospital, Uganda
Dr. MPIMBAZA Arthur Mwambari studied determinants of severe malaria among children in the Busoga sub-region. Risk factors for severe malaria included delayed care seeking by more than 24 hours after fever onset and seeking care at a drug shop as the initial response. For convenience, drug shops were the most common provider sought by caregivers of children with severe malaria. However, drug shops offered sub-optimal healthcare services compared to public health facilities. Hemoglobin S heterozygotes, alpha thalassemia heterozygosity and homozygosity were associated with protection against severe malaria. Drug shops were a problem, contributing to delay and severe malaria. The role of drug shops in caring for children with malaria needs to be re-evaluated and services at public health facilities strengthened. This study was funded by NIH Fogarty International Center (TW009343 and TW007375) and was supervised by Assoc. Prof. Charles Karamagi, Prof. Anne Katahoire, Grace Ndeezi and Philip J Rosenthal.
NABATANZI Rose (Ms)
Innate immune system recovery after long-term antiretroviral therapy in an African cohort
Dr. NABATANZI Rose studied whether key blood cell populations of HIV infected adults recover completely after at least seven years of treatment with antiretroviral therapy (ART). This research found that despite at least seven years of effective ART, key first line defence cells among HIV-infected individuals were still fewer and produced low chemical mediators of first line defence against invading germs; compared with age-matched healthy HIV uninfected individuals. More emphasis should be put on ways of improving the body’s defence system for individuals on long-term ART to levels comparable to HIV-uninfected individuals, to prevent or delay HIV-associated complications among adults aging with the disease. This study was funded by DELTAS Africa Initiative, the Wellcome Trust and UK government and Alliance for Global Health and Science at University of California, Berkeley, USA; and was supervised by Prof. Damalie Nakanjako, Prof. Moses Joloba, Prof. Stephen Cose and Prof. Sarah Rowland Jones.
NAJJUKA Christine Florence (Ms)
Characterisation of extended spectrum Beta lactamases elaborated in Enterobactereaceae in Uganda
Dr. NAJJUKA Christine Florence investigated the prevalence of Extended Spectrum beta-Lactamases (ESBLs), the factors associated with gastrointestinal carriage, genotypes, transmission dynamics and co-resistance among clients attending outpatient clinics in Kampala, Kayunga and Mpigi Districts. She found predominance of cefotaximase in Kampala and presence of plasmid-mediated AmpC beta-lactamase genes, especially in ceftriaxone-susceptible Escherichia coli. Use of ciprofloxacin, inoculation and routine health follow up were risk factors, while rural residency and visiting lower health centres were protective of carriage of resistant bacteria. Transmission was predominantly by horizontal gene transfer of cefotaximase with at least two non-beta-lactam resistance genes. The findings inform widespread gut colonisation by bacteria resistant to 3rd generation cephalosporins and commonly used non beta-lactam agents, a source for transmission and infection with unpredictable and limited treatment options. This study was funded by Sida-Makerere Bilateral Research Programme and the Carnegie Cooperation of New York, and was supervised by Prof. Moses L. Joloba and Prof. Sabiha Y. Essack.
ZIDA Andre
Creating and institutionalizing supports for evidence-informed decision making, including a rapid response service, in the Burkina Faso health system
Dr. ZIDA Andre’s research focused on decision making in the Burkina Faso health system. His investigation focused on the institutionalization of a policy support unit called rapid response to provide evidence for urgent decision-making. The study showed that the institutionalization of decision support units demands a robust framework and political will. It can be non-linear, and it depends on the leadership of unit managers to implement relevant activities, mobilize funding, and recruit and maintain sufficient human resources. This study developed a clear roadmap for evidence-informed decision-making and policy unit institutionalization. This study was funded by International Development Research Centre (IDRC) and the European Union, and was supervised by Prof. Nelson K. Sewankambo, John N. Lavis and Dr. Bocar Kouyate.
Please click the links below to navigate to the PhD Citations for the respective Sessions.
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General
Mastercard Foundation Scholars Empower Schools in Mukono and Kyegwegwa Districts
Published
3 days agoon
November 18, 2024By
Mak EditorBy Scholars Program Communication Team
On Saturday, November 16, 2024, Little Angels Junior School, Mawotto Village, Mukono District, and St. Charles Rwahunga, Nursery and Primary School in Kyegegwa District celebrated an inspiring, joy-filled event. These two schools were selected to receive the generosity of Mastercard Foundation Scholars at Makerere University during the Annual Scholars Day of Community Service.
At St. Charles Rwahunga Nursery and Primary School, the Scholars donated various products, including Learning Materials, Geometry sets, Sanitary towels for the girls, sportswear for the boys’ football team, and other goodies.
The Community Nursery and Primary School serves 412 pupils with severe challenges due to inadequate infrastructure. The buildings are dilapidated, there is a shortage of desks, and the classrooms are small and overcrowded. These issues need to be addressed to ensure a better student learning environment.
Mr. Alex Mugisha, the Headteacher of the School, expressed gratitude to the Scholars of Mastercard Foundation for the kind gesture they extended to his school.
“I am deeply grateful, along with the students and staff, for the generosity of the Mastercard Foundation Scholars. These materials will significantly enhance the learning environment for our pupils,” remarked Mr. Mugisha.
Mr. Nelson Ddumba, the Scholars Council Representative, encouraged the young learners at the event not to lose hope. He emphasized that regardless of their starting point, they can improve their circumstances by staying in school.
“Listen, my fellow students: do not give up. The only path to transforming your circumstances is through a steadfast commitment to your education and remaining in school. I have been in your shoes, but I pushed through and succeeded thanks to my mother’s unwavering support. Today, I proudly attend Makerere University, one of the leading institutions in Uganda. Embrace the challenge ahead and make your education your top priority!” Mr. Ddumba declared.
At Little Angels Junior School, pupils were excited to receive educational materials, reusable sanitary towels, mathematical sets, dictionaries, and textbooks for nursery to primary seven students.
Ms. Sarah Nturo, the headteacher, commended the Mastercard Foundation Scholars at Makerere University for the kind gesture.
She said the books will help the school improve its reading culture and performance.
“We are grateful to the Mastercard Foundation Scholars Program at Makerere University; we believe these books will significantly contribute to improving our pupils’ performance,” Ms. Nturo said.
Nturo also pointed out that they have challenges with the facilities and water as a school.
“Ever since we started this School, the education has improved because, in the past, parents could not allow their children to come here; instead, they would send them to the lake for fishing. But now, the children come only because they do not have somewhere to sit. We have few desks,” Nturo said.
During the visit, the pupils mesmerised the scholars with rare dance moves. The excitement did not leave the Programme Implementation team and teachers in their seats, making it a fun-filled event. The audience was left yearning for more.
Addressing the school, Mr. John Osuna, the Transition Lead at the Mastercard Foundation Scholars Program, urged the pupils to use their school time to prepare for a bright future.
“Do not mind where you are coming from. We all started like this. Education is an equalizer. Now that you have an opportunity to study, focus on making the best out of it. Be disciplined pupils and listen to your teachers. The sky will be the limit,” Mr Osuna said.
During the event, Francis Kabuye Kaggwa, the Chairperson of the Parents Teacher Association (PTA) leadership, said that ever since the school started over 10 years back, they have never received guests who bring them gifts like how the Mastercard Foundation Scholars did.
“I think you have seen how excited the children were. We are all happy this has never happened to our school. Who are we to receive these gifts? We have challenges, but with friends like God on our side, we shall conquer,” Mr. Kabuye noted.
The Scholars’ Day of Community Service is an annual event where Mastercard Foundation Scholars at Makerere University engage in community service as a way of giving back. This initiative aims to empower vulnerable individuals in the community and contribute positively to society.
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Prof. Nawangwe calls for Increased Government Sponsorship for Students with Disabilities
Published
7 days agoon
November 14, 2024By
Mak EditorBy Mak Communication Team
The Vice Chancellor, Prof. Barnabas Nawangwe, while speaking at the inaugural commemoration of the International Day for Persons with Disabilities at Makerere University has appealed to the Government to increase the number of students with disabilities on government sponsorship.
The event held on Wednesday, 13th November 2024 was organised by the Office of the Dean of Students and the 90th Students’ Guild-Ministry of Students with Disabilities and held in the Yusuf Lule Central Teaching Facility Auditorium.
The day’s theme was: “Empowering Inclusion: Breaking Barriers, Unlocking Potential”
“Students with disabilities should be the first to be admitted on Government sponsorship because there are not so many,” Prof. Nawangwe said.
Prof. Nawangwe called upon the government to devise a scheme and policy for integrating students with disabilities into the working environment after graduation.
Prof. Nawangwe noted that the University has established a Disability Support Centre, a one-stop facility to ensure equal access to education and life, promote inclusivity, and support students and staff with disabilities.
“Over the years, Makerere University has branded itself as a place that actively and loudly promotes increased awareness about the rights and needs of students and staff with disabilities.” Prof. Nawangwe remarked.
While addressing the gathering, the Chief Guest, Hon. Hellen Grace Asamo, the State minister for Disability Affairs, called upon Persons with Disabilities to always believe in themselves and be able to break the barriers of the inferiority complex.
“You have to show people that you have the potential, and when people get to know your potential, they will begin to include and engage you. But if you do not have your potential, nobody will include you. They will think you are just someone who is just there seated and begging,” Hon. Asamo noted.
In her welcome remarks, Dr. Winifred Kabumbuli, the Dean of Students at Makerere University, said that the University is making a deliberate effort to pay particular attention to the decisive implementation of inclusive Policies and Practices.
“This is where we want all people to thrive and grow. Therefore, we are proud to accept and celebrate our differences and uniqueness. We welcome you here to build a culture of active support for each other and to declare that by championing a conducive environment for students and staff with disability, we are part of the change-makers of today,” Dr Kabumbuli said.
Dr. Kabumbuli also highlighted several policies the University has implemented, such as the Policy for Persons with Disabilities and safeguarding, Accommodation policy, University rules and regulations, the Human resource manual, and the student guild constitution that provides inclusive participation in student leadership and admission policies.
“These policies protect and enhance the rights of both staff and students with disabilities. For example, we have a student guild minister for persons with disabilities to ensure their voices are heard,” Dr. Kabumbuli noted.
Makerere has directed attention to ensuring accessible and comfortable accommodations for students with Disabilities by having designated accessible hostels and rooms. The University provides salaries, lodging, and meals for helpers who assist students with disabilities. A concentrated effort is also being made to build ramps, elevators, and accessible pathways to facilitate navigation for students and staff.
According to Dr Kabumbuli, the University has embraced a drive to facilitate students’ access to assistive devices, including wheelchairs, white canes, brailling machines, hearing aids, etc.
“As part of our commitment to inclusivity and accessibility, the University has designated a specialized space within the library, equipped with assistive technologies and resources, specifically for students with disabilities to ensure equal access to knowledge and academic success for all. We have also put in place special arrangements, such as extra time during examinations to enable access to education,” Dr Kabumbuli said.
Dr. Kabumbuli acknowledged the support from the Mastercard Foundation Scholars Program, the Ministry of Gender, and the School of Law, which are committed to championing diversity, inclusion, and equity for People with Disabilities.
The International Day of Persons with Disabilities is celebrated annually on December 3rd to raise awareness and support for people with disabilities worldwide.
General
The 3rd Fundis and Technicians sensitization event and exhibition held successfully
Published
3 weeks agoon
November 2, 2024The 3rd annual Fundis and Technicians sensitization event and exhibition by manufacturers of building materials organized by the Department Architecture and Physical Planning at the College of Engineering, Design, Art and Technology (CEDAT), Makerere University came to a close with a call for increased partnerships between training institutions and the community.
The event that attracted 200 participants including masons, fundis, painters, builders, metal and electrical fabricators ran from Thursday 24th to Friday 25th October 2024 at CEDAT. It was supported by several stakeholders and was characterized by training sessions and an exhibition of building materials by different companies that make cement, paint, water tanks tiles and many more.
Prof. Henry Alinaitwe, the Deputy Vice Chancellor in charge of Finance and Administration represented the Vice Chancellor, Prof. Barnabas Nawangwe at the opening of the training. In his remarks, he extended appreciation to the technicians for accepting to take part in the training which he said was key in ensuring that they gain from continuous learning. Prof. Alinaitwe observed that although some of them did not get through formal training, it was important that they took part in such training programs to keep abreast of the developments in the construction industry where they undertake the bulk of the work as masons, technicians, plumbers, and metal fabricators.
‘Keep improving, we need to up our game in terms of quality’, he said while making reference to the need for quality output. He cautioned them on issues of cost and cheating of their clients by making realistic costs. ‘We need to cost the work well taking into account the materials, the labor, the equipment used, and the overheads’. The other area that needed to be taken care of by the technicians included time management, which reflects on attitudes towards work, team work. While addressing the gathering in his capacity as Chairman of the Engineers Registration Board, Prof. Alinaitwe said the upcoming engineering Registration Bill, if approved, has a provision for the registration of all artisans and hence the need to have the minimum requirements for the stakeholders to be registered. He also stressed the need to bring on board as more women as possible. ‘We want to see more women, who can do some aspects in construction better than men like painting.
Prof. Moses Musinguzi, the Principal of the College of Engineering, Design, Art and Technology while welcoming the trainees to the college said the training is a good initiative that will help address challenge of skill and work match. He encouraged the trainees to do smart work, and take due consideration of ethics and customer care. He encouraged the department to extend the training opportunity to other units of the college and the university and also make it more formal, as part and parcel of the training program of the college in liaison with bodies like UBTEB.
Assoc. Prof. Kizito Maria Kasule, the Deputy Principal CEDAT while appreciating the initiative of the department said countries like Germany have apprenticeship training that help the training of students to gain skills equivalent to those acquired while in formal institutions of learning. He said the academia in Uganda is increasingly recognizing the importance of the informal sector in the growth of the country. ‘We need to learn from you. Almost 90% of the people in the construction industry have been informally trained’. He said by learning from each other, the two sectors jointly make a contribution towards the development of the country.
Dr. Amin Tamale Kiggundu, the head of the Department of Architecture and Physical Planning said the initiative, a community outreach program of the college started three years ago in the year 2022 with 60 Fundis and masons, in 2023, the number was increased to 120 Fundis and the current 2024, was 200 Fundis of various categories, including painters, builders, metal fabricators, plumbers and electrical fabricators. He said this community outreach program aims at sharing the accumulated scientific knowledge in building, design and construction technologies at CEDAT, sharing the expertise, knowledge and experiences with communities in greater Kampala and hence bridging the existing knowledge and skills gap between the training institutions and the communities.
The 21st century is characterized by collaboration, partnerships, and establishment of knowledge economies. He said based on the trainings held so far, it is clear that partnerships between the training institutions and the communities were possible especially the Fundis who are closer to the communities. ‘We also want to learn from the Fundi’s experiences, how they are able to connect to the communities in some cases better than those who have gone through the training institutions’, he said. He further noted that the majority of fundis are young people that need to be supported with skills and other ways of nurturing them. The dream of the department, he said is to introduce an open door policy that allows fundis and other university students to come to learn.
Several organizations supported the event and participated in the exhibition and they included Habitat for Humanity, Uganda, Green Building Council Uganda, The National Building Board, Uganda Clays Limited, Centenary Bank, Steel and Tube Industries Ltd, Simba Cement, Plascon, Goodwill, Cresttanks among others.
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