Research

Genetic Basis of Maize Resistance to Multiple Insect Pests

Published

5 years ago

June 24, 2020

Mark Wamai

A male researcher inspects a maize cob in a demonstration plot at the Makerere University Agricultural Research Institute Kabanyolo (MUARIK), Wakiso Uganda. Date taken: 13th August 2010.

Several species of herbivores feed on maize in field and storage setups, making the development of multiple insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical maize lines was evaluated in three field environments for resistance tofall armyworm (FAW), whilst bulked grains were subjected to a maize weevil (MW) bioassay and genotyped with Diversity Array Technology’s single nucleotide polymorphisms (SNPs) markers. A multi-locus genome-wide association study (GWAS) revealed 62 quantitative trait nucleotides(QTNs) associated with FAW and MW resistance traits on all 10 maize chromosomes, of which,47 and 31 were discovered at stringent Bonferroni genome-wide significance levels of 0.05 and 0.01,respectively, and located within or close to multiple insect resistance genomic regions (MIRGRs)concerning FAW, SB, and MW. Sixteen QTNs influenced multiple traits, of which, six were associated with resistance to both FAW and MW, suggesting a pleiotropic genetic control. Functional prioritization of candidate genes (CGs) located within 10–30 kb of the QTNs revealed 64 putative GWAS-based CGs (GbCGs) showing evidence of involvement in plant defense mechanisms. Only one GbCG was associated with each of the five of the six combined resistance QTNs, thus reinforcing the pleiotropy hypothesis. In addition, through in silico co-functional network inferences, an additional107 network-based CGs (NbCGs), biologically connected to the 64 GbCGs, and differentially expressed under biotic or abiotic stress, were revealed within MIRGRs. The provided multiple insect resistance physical map should contribute to the development of combined insect resistance in maize.

Business & Management

PIM CoE Magazine Issue 1: Jul-Dec 2024

Published

23 minutes ago

February 5, 2025

Betty Kyakuwa

Cover page of the Public Investment Management Center of Excellence (PIM CoE) Magazine Issue 1: July - December 2024. College of Business and Management Sciences (CoBAMS), Makerere University, Kampala Uganda, East Africa.

The Public Investment Management Center of Excellence (PIM CoE) was conceived as a result of the 2016 PIM Diagnostic study done by the World Bank and Ministry of Finance Planning and Economic Development with support from Makerere University School of Economics that discovered inefficiencies in PIM in Uganda.

This report highlights the work, achievements and prospects of the Center. The Center plans to start offering Advanced level training through Post Graduate Diploma (PGD) in PIM and Master of Science in Economic and Investment Modelling (MEIM). I am pleased to introduce this report to the public for use by all stakeholders.

I would like to appreciate PIM CoE Secretariat, partners, staff and well-wishers for technical support, daily running of the Center and their role in the realization of these achievements.

Special thanks go to Ministry of Finance, Planning and Economic Development, National Planning Authority, Cambridge Resources International (CRI) and Makerere University for the overwhelming support rendered towards the development of the Center.

Prof. Edward Bbaale
Principal & Principal Investigator, CoBAMS/PIM CoE

Makerere-CoBAMS-PIM-CoE-Magazine-Issue-1-Jul-Dec-2024 Download

Research

CARTA Graduate Dr. Drago on Advancing Research in Infectious Diseases

Published

2 days ago

February 3, 2025

Mark Wamai

Dr. Kato Charles Drago at work in the Lab. Photo: CARTA.

In our latest ‘Stories of Change’ feature, CARTA graduate, Kato Charles Drago, cohort 3, Makerere University shares his journey from an early-career scientist to a leading expert in infectious disease in Uganda. His work focuses on biomarkers for zoonotic diseases, securing over $5 million in research funding, and establishing a biosafety level 2 lab for high-impact research at Makerere. Beyond his research, Kato is mentoring the next generation of African scientists and strengthening regional collaborations.

Read the full story here

Source: CARTA Newsletter Issue 85

General

CARTA Fellow Dr. Wandera Receives Research Excellence Award

Published

2 days ago

February 3, 2025

Mark Wamai

Right to Left: Prof. James Wokadala, Prof. Edward Bbaale, Dr. Allen Kabagenyi, Dr. Stephen Ojiambo Wandera, Dr. Patricia Ndugga and Ms. Namugenyi Christabellah. Convocation Luncheon, 75th Graduation Ceremony, Day 2, CoBAMS, CHS and CoNAS. 14th January 2025, Research, Teaching, Students Excellence Awards, Edge Road, Makerere University, Kampala Uganda, East Africa.

Stephen Wandera, cohort 2, Makerere University, was nominated for the prestigious Vice Chancellor’s Research Excellence Award 2025. This nomination recognizes his outstanding contributions to research excellence. The award ceremony took place on January 14, 2025, during the Convocation luncheon, following the 75^th graduation ceremony of Makerere. We congratulate Stephen on this significant achievement and commend his dedication to advancing research within his field.

Source: CARTA Newsletter Issue 85