Veterinary & Biosecurity
Makerere University Hosts Stakeholders Workshop on One Health approach to understanding Climate Change and Zoonoses
By Joseph Odoi
On January 30-31, 2025, Makerere University in partnership with Glasgow, UK and University of Stockholm, Sweden with support from Europe’s CIVIS University Alliance, organized a multi-disciplinary workshop at Kabira Country Club, Kampala, Uganda entitled “One Health and Diagnosing Zoonoses – Understanding the Importance of Climate Change in Disease Prevalence.” The event brought together a diverse group of stakeholders, including academicians, researchers, and practitioners, to collaborate on addressing public health challenges at the intersection of human, animal, and environmental health.
The workshop was organized and officially opened by Associate Professor Lawrence Mugisha from the College of Veterinary Medicine, Animal Resources, and Biosecurity (CoVAB), Makerere University alongside Professor Jonathan Cooper from the University of Glasgow, who led the CIVIS Alliance team to Uganda.
In his opening address, Prof. Mugisha welcomed participants and outlined the key objectives of the workshop. He noted that the primary aim of the workshop was to build new pathways for knowledge exchange and strengthen One Health capabilities within Uganda and East Africa in order to develop a better understanding of the role of climate change in disease dynamics (including zoonoses) in humans and animal health and their wellbeing.
Furthermore, the workshop sought to explore the regional links between zoonotic disease prevalence and climate change by using appropriate digital tools/systems that will, in future, have the potential to be used more widely in Sub-Saharan Africa.
On the impact of Climate Change in Disease Prevalence, Professor Mugisha noted that the World Bank, the World Health Organization (WHO) and World Organisation for Animal Health (WOAH) have all warned around the need to better understand the harmful effects of climate change on health and disease, especially in low-and-middle-income-countries with such effects readily seen with Sub-Saharan Africa suffering some of the worst impacts.
‘’Uganda is also considered as a ‘hot spot’ for emerging and re-emerging infectious disease epidemics. The country has experienced several epidemics including; Ebola, Marburg, Plague, Rift Valley Fever, Yellow fever and Crimean Congo hemorrhagic fever. ‘’Many of these public health challenges arise from the interaction between humans-animals-environment and require a One Health approach as a collaborative effort of multiple disciplines working locally, nationally, and globally, to attain optimal health for people, animals, plants and the environment.’’ added Professor Mugisha.
In his remarks, Professor Jonathan Cooper from the University of Glasgow acknowledged participants and provided a brief background on the CIVIC University Alliance. He stated that under CIVIS, multiple universities collaborate to offer joint learning pathways, research opportunities, and diverse degree programs, creating a dynamic network where students and academics can move freely between institutions. Through this collaboration, they work together to address societal challenges, including One Health and climate change, while also developing real-world solutions. He also commended the collaborative efforts of Makerere University, particularly those of Professor Lawrence Mugisha, in working across multiple disciplines at local, national, and global levels to achieve optimal health for people, animals, plants, and the environment.
Prof. Mugisha delivered a keynote address on climate change and human health and highlighted how climate change is causing unprecedented threats to human health, driving emergence of new infectious diseases and exacerbating the existing ones in addition to fueling frequent occurrence of severe natural catastrophes like floods, hurricanes and wildfires. He reported as per World Economic Forum Report of 2024, that climate change is projected by 2050 to cause additional 14.5 million deaths and $12.5 trillion in economic losses worldwide. He called upon all stakeholders to act together through research, innovations and public directed interventions to reverse the potential impact of climate change. He provided examples of different research consortiums working together to contribute to finding solutions to address the impacts of climate on health of humans, animals and entire ecosystem. Highlighted Projects include DIDIDA-Improving disease diagnosis in Africa (Home – Didida), PREPARE4VBDS— A Cross-Disciplinary Alliance to Identify, PREdict and prePARE for Emerging Vector-Borne Diseases (prepare4vbd.eu) and recently funded DIDIDI- development of advanced, low-cost and deployable digital dashboards and diagnostics to understand how changes in climate are affecting the dynamics of soil-transmitted helminth (STH) and schistosomiasis in underserved rural community settings in sub-Saharan Africa
Dr. Frederick Monje, a focal person for the One Health Platform from the Ministry of Agriculture, Animal Industry and Fisheries (MAAIF), provided a brief background of the National One Health Platform of Uganda. He stated that the platform was established in 2016 to serve as a multi-sectoral coordination mechanism aimed at addressing public health threats arising from the interactions between humans, animals, and the environment.
Dr. Monje emphasized that the National One Health Platform in Uganda plays a critical role in surveillance, early detection, and rapid response to outbreaks through collaborations with district health teams, universities, and research institutions. He noted, “One Health is one of the ways to prevent the next pandemic. We need to do a lot of preparedness to prevent cross-cutting public health threats from coming to us. We have developed a number of training and partnerships with universities and many stakeholders to achieve the One Health objective.”
In his presentation, Mr. Monje also cited the World Bank’s report, highlighting that globally, zoonotic diseases sicken 2.4 billion people annually, kill 2.2 million, and affect more than 1 in 7 livestock. The direct economic costs of zoonotic diseases are estimated at 20 billion dollars per year. He pointed out that Uganda, due to its proximity to the Congo Basin and other hotspots, faces significant public health threats from zoonotic diseases.
Mr. Monje further emphasized that the platform’s impact is evident in its district-level One Health teams, which have strengthened Uganda’s pandemic preparedness and response to zoonotic diseases such as Ebola, Rift Valley Fever, and anthrax. He reiterated that One Health is critical to preventing future pandemics, requiring continuous preparedness, collaboration, and policy development to safeguard public health.
In her presentation, Ms. Patricia Nyinguro- Principal Meteorologist at the Kenya Meteorological Department revealed that there is rising temperatures in Kenya, showing an increasing trend since 1961, particularly in semi-arid regions. Despite this, she noted that public perception of heatwaves is low yet rising temperatures are key drivers of heat-related mortality, morbidity, and infectious diseases.
Moving forward, Ms. Patricia emphasized the importance of interdisciplinary collaboration in developing heat health action plans and called for the development of indicators to measure progress in climate change adaptation.
In a digital technologies session, Dr. Xin Guo from the University of Glasgow shared insights on mobile health platforms for diagnostics, including demonstrations of relevant applications. He showed how apps can help diagnose diseases, especially zoonotic ones, and improve healthcare, especially in areas that need better disease tracking and response.
Participants engaged in discussions on zoonoses, its impact, and the importance of the One Health approach. Key questions explored included: What are zoonoses? Why is One Health crucial? Who are the stakeholders involved, and how can zoonoses be effectively addressed?
Using the Double Diamond Methodology, participants in group discussions also identified the most pressing challenges that climate change poses or will pose on zoonoses, potential solutions, and the reasons why these solutions aren’t being implemented yet.
Key outcomes from the engagement included the drafting of a policy brief outline, which will guide future initiatives aimed at tackling public health threats.
The workshop also tackled important issues such as data interoperability, data ownership and management, and ethics and privacy. These topics were thoroughly explored during structured discussions, with a particular focus during the Early Career Researcher (ECR) session.
Dr. Paul Mbanka, Assistant Commissioner of Health Services, outlined the Ministry of Health’s commitment to addressing Zoonoses related cases citing presence of an incident management system, which includes an SMS-based mechanism for reporting diseases to the emergency response center. Upon detection of an alert, the information is verified, samples are collected, and if confirmed, a response is initiated. In terms of areas for improvement, Dr. Mbanka acknowledged the challenge of information sharing across various sectors. When asked about Data sharing by workshop participants, He also stated that the Ministry of Health is open to sharing data with researchers, provided it supports the Ministry’s goals
The two-day workshop concluded with an emphasis on the critical need for continued collaboration in the One Health sector. Participants, including Researchers, Academicians, PhD and Master’s students from Makerere University, and Uganda and Kenya registered students at Glasgow University made presentations and also engaged in strategic discussions on tackling zoonotic diseases, climate change, and the integration of digital innovations in health data management.
To conclude the workshop, Prof. Lawrence Mugisha, Professors Julien Reboud and Jon Cooper of the Makerere University and University of Glasgow respectively expressed their appreciation to all participants for the insightful presentations, discussions and emphasized the importance of ongoing partnerships across human, animal, and environmental health sectors.
Veterinary & Biosecurity
Alumni of Molecular Biology Honor Prof. George William Lubega for Outstanding Contributions
Veterinary & Biosecurity
Uganda Advances Bacteriophage Research in Fight against Antimicrobial Resistance
Makerere University convened a symposium to explore bacteriophage applications in combating antimicrobial resistance (AMR) and addressing health, agricultural, and environmental challenges. Organized by The Alliance for Phage Research and Development Uganda Ltd (PhageTeam Uganda), the event brought together researchers from Makerere University, Kyambogo University, Kampala International University, and Ian Clarke International University, and other players, highlighting a collaborative approach to tackling global and local issues.
Day two of the symposium saw researchers and policy makers together with partners from the UK and USA hold a discourse on the best way forward in the promotion of bacteriophage research and production in the country to support efforts against anti-microbial resistance.
Speaking at the event held at Hilton Garden Inn, Dr. Jesca Nakavuma, the lead phage researcher from the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, stressed the urgent need for alternative antimicrobial agents due to the rise in drug resistance and limited discovery of new antibiotics. Bacteriophages, natural viruses that target bacteria, she said, were identified as a promising solution to revolutionize disease control, treatment, and food security. She said research in this area was key because humankind was at risk of the impending calamity of life-threatening treatment failure.
Prof. Robert Wamala, Makerere University‘s Director for Research, Innovations, and Partnerships, who spoke on behalf of the Vice Chancellor, Prof. Barnabas Nawangwe, underscored the importance of building local capacity in phage research. He noted that such efforts could enhance Uganda’s resilience against AMR and yield homegrown solutions for human, animal, and crop health.
As the world grapples with the growing threat of antimicrobial resistance (AMR), bacteriophage research offers a promising alternative. Phages, which are natural enemies of bacteria, have the potential to revolutionize the approach to treatment, disease control, and food security, he noted. He said building local expertise in phage application can enhance Uganda’s resilience against AMR and produce sustainable homegrown solutions to health and environmental challenges.
Prof. Robert Wamala said Makerere University was committed to supporting cutting-edge research and innovation that addresses national and global challenges in line with the university’s role in knowledge generation, technology advancement, and policy influence. The importance of regulatory institutions, he said, cannot be overemphasized in this endeavor, since they enforce compliance, uphold ethical standards, and foster an enabling environment for impactful research and innovation. He said the engagement presented an opportunity to strengthen collaboration between researchers, institutions, and regulatory bodies to ensure that the outcomes are scientifically sound and are aligned to the national development priorities and global best practices.
Dr. Claire M. Mugasa, the Dean of the School of Biosecurity, Biotechnical and Laboratory Sciences (SBLS), CoVAB reiterated the fact that antimicrobial resistance was on the rise in Uganda and Africa, more than elsewhere in the world. She said it was time now that efforts be intensified in looking for sustainable options to curb the dangerous trends. She said this cuts across the human and the animals. She said it was an opportune time for players to come together to find ways of getting the required alternative. She said by coming together, the different ideas developed individually would in a concerted effort, pulling resources together for a way forward.
During the discourse, several subjects were addressed, including an introduction to antimicrobial resistance, phage biology, phage application, and lessons learnt from the establishment of a phage research centre in the UK, which was presented by Prof. Martha Clokie from the University of Leicester. This initiative reflects a commitment to fostering innovation, collaboration, and regulatory compliance, positioning Uganda as a leader in sustainable solutions for global challenges.
The symposium was sponsored by Global AMR Innovation Fund (GAMRIF), through a grant to the UK Medicines and Healthcare products Regulatory Agency (MHRA) in partnership with Phages for Global Health.
Veterinary & Biosecurity
First Symposium on Bacteriophage Research & Applications in Uganda Highlights Remarkable Milestones & Future Prospects
Bacteriophage research and its applications were the focal point of the 1st Symposium on Bacteriophage Research and Applications, convened by Makerere University‘s College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB) on Thursday, March 27, 2025. This landmark event showcased Uganda’s strides in harnessing bacteriophages as innovative solutions to antimicrobial resistance (AMR) and other pressing health and agricultural challenges.
Key speakers included Dr. Jesca Nakavuma, CoVAB (Makerere University), who showcased Uganda’s pioneering phage research initiatives and vision. Tobi Elaine Nagel, the President of Phages for Global Health (USA), discussed the global significance of phage research. Prof. Martha Clokie, from the University of Leicester’s Centre for Phage Research (UK), shared insights into the latest advancements in phage therapy. Dr. Robert Blasdel, representing VASALE (Belgium), presented innovative solutions using bacteriophages. Ms. Abigail Riggs, from the Foreign, Commonwealth and Development Office (UK), emphasized international partnerships and policy development.
Speaking at the event, Prof. Edward Wamala, Makerere University’s Director of Research, Innovation and Partnerships, who represented the Vice Chancellor Prof. Barnabas Nawangwe at the event, highlighted the critical role of bacteriophage research in addressing the global threat of antimicrobial resistance (AMR). He explained how the misuse and overuse of antibiotics in human health, agriculture, and aquaculture have accelerated the emergence of drug-resistant bacterial strains, rendering standard treatments ineffective. Citing statistics from the World Health Organization, he pointed out that AMR claims over 1.3 million lives annually, a number expected to rise without urgent action. He lamented the stagnation of new antibiotic development due to high research costs and rapid bacterial resistance, making bacteriophage therapy a powerful and promising alternative.
Prof. Wamala expressed Makerere University’s commitment to advancing research that addresses critical societal challenges, aligning with its mission of generating transformative knowledge and fostering sustainable development. He emphasized Uganda’s potential to lead in bacteriophage research, driven by multi-disciplinary partnerships and capacity building. He also highlighted ongoing studies into aquaculture-specific bacteriophages at CoVAB as an example of how phage technology can revolutionize sectors like agriculture while addressing AMR. Through such efforts, the university aims to position Uganda as a global leader in innovative solutions to combat antimicrobial resistance and enhance public health.
Dr. Jesca Nakavuma, widely regarded as the mother of phages in Uganda, delivered a compelling presentation at the Symposium, where she detailed the impressive progress of phage research in Uganda since its inception in 2017. She highlighted Makerere University’s pioneering efforts, starting with a cohort of five undergraduate students, which have since expanded into groundbreaking research addressing challenges in agriculture, clinical health, food safety, and environmental safety. Key achievements include advancements in E. coli and Salmonella detection, tackling avian colibacillosis, and innovations in decontamination methods, underscoring the transformative potential of phage technology in combating antimicrobial resistance and enhancing public health.
The symposium honored collaborative efforts, including the establishment and accomplishments of Phage Team Uganda, which developed a repository of 125 characterized phage isolates and trained over 20 PhDs, MScs, and BSc students. Partnerships with international organizations such as IDRC InnoVet AMR and AU Safe Fish have significantly contributed to advancements in antimicrobial resistance and aquaculture.
Despite these achievements, Dr. Nakavuma noted challenges such as insufficient facilities for large-scale phage production, regulatory limitations, and financial constraints. She affirmed that despite the challenges, the team remained ambitious, envisioning the creation of a fully equipped Phage Research and Development Center, the commercialization of phage products, and the establishment of policy frameworks to support the use of phages in Uganda.
The Deputy Principal of CoVAB, Prof. James Acai Okwee, warmly welcomed the partners to the conference and acknowledged their invaluable contributions to the college’s research efforts. He emphasized the importance of collaboration in driving innovation and achieving impactful results, highlighting the pivotal role that partnerships play in fostering academic and scientific growth. Prof. Okwee’s remarks set an encouraging tone for the conference, reinforcing the college’s commitment to advancing research initiatives and creating opportunities for shared learning and development.
The event that attracted the participation of various stakeholders including academia, civil society, and policy makers, concluded with acknowledgments of the efforts of Phage Team Uganda, collaborators, and funders, setting the stage for an exciting future in Uganda’s journey to combat antimicrobial resistance and ensure food and environmental safety.
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