Natural Sciences
PAIRWISE Project Engages Mbarara Stakeholders on Antibiotic Resistance
Most of the antibiotics used to manage diseases in humans and livestock end up in the environment. Antibiotics (ATBs), Antibiotic Resistant Bacteria (ARB), and Antibiotic Resistance (ARGs) have spread in almost all habitats globally. The Food and Agricultural Organization (FAO), World Health Organization (WHO), and the World Organization for Animal Health (OIE) recognize the problem of Antimicrobial Resistance (AMR), and thus recommend: Prudent use of antimicrobials; and a “One Health Approach” to mitigate the problem. Antimicrobial Resistance (AMR) is a situation where bacteria develop resistance against antibiotics intended to destroy them.
Antibiotics in the environment may induce AMR in bacteria, hence the risk of transfer to humans and wildlife. AMR reduces effectiveness of antibiotics, leading to higher costs of treatment, severe illnesses, and deaths. Globally, about 1.2 million people died in 2019 due to complications of AMR; Sub-Saharan African region alone had 255,000 deaths (Murray et al., 2022, The Lancet, https://doi.org/10.1016/S0140-6736(21)02724-0).
The Strategic Research Agenda by the Joint Programming Initiatives (JPI) calls for transnational studies on AMR in both terrestrial and aquatic environments. Indeed, the role of livestock, wildlife and migratory birds in the spread of AMR has previously been under-emphasized, yet they are major reservoirs of ARB and ARG.
The PAIRWISE Project is being implemented in three countries in Europe, and two in Africa. PAIRWISE is investigating the risks posed to human health and the environment by pollutants and pathogens present in water resources. The project also aims to investigate the dispersal of ATB, ARB and ARG downstream Wastewater Treatment Plants (WWTPs) by comparing different geographical/climatic regions, wastewater management practices and types of water bodies.
Project partners include; National Veterinary Institute (SVA), Sweden; Norwegian Institute for Water Research (NIVA), Norway; Linköping University (LiU), Sweden; Doñana Biological Station, Higher Council for Scientific Research, Spain; National Research Institute for Rural Engineering, Water, and Forestry, Tunisia; Faculty of Medicine Ibn Al-Jazzar Sousse, Tunisia; and the College of Natural Sciences, Makerere University, Uganda.
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 869178-AquaticPollutants, Joint Programming Initiative on Anti-microbial Resistance (JPIAMR), www.waterjpi.eu; and JPI Oceans, www.jpi-oceans.eu. For Uganda, the three-year project is funded by the Swedish International Development Agency (Sida). The African Population and Health Research Center, Nairobi, www.aphrc.org coordinates the funding in Uganda.
In Uganda, the research activities are being conducted by researchers from the College of Natural Sciences, Makerere University including: Prof. Charles Masembe (Principal Investigator), Dr. Robinson Odong, Dr. Peter Akoll, Mr. Mayega Johnson (Department of Zoology, Entomology and Fisheries Sciences) and Mr. John Omara (Department of Biochemistry and Sports Sciences) as team members. The study area in Uganda includes the catchment of River Rwizi, Lake Mburo National Park, and River Aswa.
The research will contribute towards better understanding of the factors which influence the occurrence and spread of AMR in water systems, livestock farms, and birds. It will also contribute towards the Government of Uganda’s framework to combat the threat of AMR, through the National AMR Action Plan; design policies to reduce the risks of AMR, and the costs incurred for animal and human disease management.
Makerere University PAIRWISE Consultative Meeting in Mbarara
On 31st May 2022, the project team from the Department of Zoology, Entomology and Fisheries Sciences led by Prof. Charles Masembe (Principal Investigator) held a consultative meeting to get buy-in and introduce the PAIRWISE Project to the key stakeholders in Greater Mbarara and River Rwizi catchment. The meeting also aimed to receive input from key stakeholders regarding the use of antibiotics in Greater Mbarara district and River Rwizi catchment, to document challenges of Antimicrobial Resistance and identify potential sites for fieldwork.
The meeting was attended by administrators, senior health, water and environmental officers in Mbarara City and District including:
- The District Chief Administration Officer represented by Mr Bakashaba Innocent
- Mr David Nuwagaba, the District Natural Resources Officer
- Mr Tumwebaze Herbert, Environment Officer, Mbarara City
- Dr Oriokot Francis, Deputy Director, Mbarara Regional Referral Hospital
- Dr Akashaba Andrew, Mbarara District Veterinary Officer
- Mr Mwesigye Joseph, Environment Officer, Mbarara District
- Mr Katongole Joseph, a farmer in Mbarara District
Mr Ayebare Calist, Fisheries Officer, Isingiro District, and a fresh graduate (May 2022, Makerere University 72nd Graduation) assisted in organizing the Stakeholders meeting. During the meeting, Dr Robinson Odong on behalf of Prof. Charles Masembe shared the project overview with participants, outlining the challenges of AMR, and expectations from the research. Stakeholders brainstormed and listed the commonly used antibiotics and the potential sites for sample collection. The research will take the One Health Approach, encompassing aspects of human, animal and environmental health.
Capacity Building under PAIRWISE Project
As part of the PAIRWISE capacity building component, the project is supporting research activities of two graduate students: Ms. Ndinawe Ruth Pamela (Master of Science in Molecular Biology) studying “The dispersal of antimicrobial resistance bacteria and genes through aquatic birds under different climatic and geographical conditions”; and Mr. George Katende (Master of Science in Immunology and Clinical Microbiology), studying “Characterization of clinically important antibiotic resistant bacteria and genes in river waters upstream and downstream of WWTPs and hospital effluent” https://cns.mak.ac.ug/blog/call-applications-msc-scholarship-under-pairwise-project.
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Overview
The Ugandan government has increasingly recognized the critical role of science education in driving the nation’s economic development. As such, it has put in place deliberate policies aimed at popularizing science education in schools. This initiative seeks to equip the youth with the knowledge and skills necessary to contribute effectively to the country’s development. Since 2004, science education has been made compulsory in lower secondary schools, and the Uganda Government has continuously emphasized the importance of science and technology through policies like the National Science, Technology, and Innovation (STI) Policy, introduced in 2009. These policies aim to create a strong foundation for the country’s “Transformation for Prosperity,” focusing on technological innovation and development. The introduction of astronomy and space science as part of the curriculum supports this vision, offering students the tools to explore scientific concepts that will drive future innovation.
About the Project – Use of Astronomy and Space Science to Promote Science Education in Schools
In an initiative geared towards bolstering science education in Uganda, Makerere University Department of Physics is leveraging the wonders of astronomy and space science to ignite curiosity and enthusiasm among learners. The project, led by Prof. Florence Mutonyi D’ujanga from the Department of Physics has reached 10 schools in Kampala, Luwero, and Mukono districts, using the vast universe to inspire the next generation of scientists, engineers, and mathematicians. The astronomy outreach activities have impacted numerous schools across different regions in Uganda. The initiative started during the COVID-19 lockdown, with initial outreach to nearby schools in Kampala. As the programme gained momentum, it expanded to various districts, benefiting students from both primary and secondary levels. The schools that have participated in the programme include, Kampala: Makerere College School and Makerere CoU Primary School, Luwero: Mulusa Academy (Wobulenzi), Wobulenzi Bright Parents, Janan Luwum S.S., and Janan Luwum Nursery & P/S, MUkono: Our Lady of Africa S.S., Kyesereka CoU P/S, Mpoma Royal College, and Mpoma Junior School.
Aims and Objectives of the Project
Funded by the Government of Uganda through the Makerere University Research and Innovations Fund (MakRIF), the central aim of this initiative was to use astronomy and space science to capture the imagination of students, encouraging them to embrace the study of science and mathematics. “By engaging students in hands-on, interactive learning activities, the project seeks to improve their performance in these critical subjects. The initiative focuses on making science enjoyable, accessible, and inspiring, fostering a positive attitude toward the subject from an early age,” explained Prof. D’ujanga.
Activities conducted
The project began with a questionnaire to assess the students’ initial understanding of astronomy, followed by tailored outreach activities that addressed gaps in knowledge and sparked excitement about the subject. The activities included;
- Telescope Assembly: Students learned to assemble telescopes using local materials, helping them gain a hands-on understanding of how astronomy tools function.
- Sky Viewing: Students had the opportunity to observe celestial bodies like stars, planets, and constellations, experiencing the universe up close.
- Cultural Astronomy Storytelling: This component introduced students to the rich cultural narratives surrounding astronomy, linking science with history and tradition.
- Astronomy Quiz Sessions: Fun, educational quizzes challenged students’ knowledge of astronomy, stimulating a deeper interest in the subject.
- Planetarium Shows: The project also featured immersive planetarium shows, which are a highlight for many students. These shows provided an exciting visual experience, where learners could see projections of stars, planets, and other celestial phenomena. The planetarium is at the heart of this outreach programme. Traditionally used for educational purposes in the field of astronomy, the planetarium has a hemispheric domed ceiling, which serves as a projection screen for images of celestial objects. The immersive environment fosters curiosity and excitement among learners, laying a solid foundation for further study in science. One of the main objectives of the planetarium shows is to break down the myth that sciences are difficult. By using visual and interactive methods, the project demonstrates that learning about space and the universe can be both fun and inspiring.
Project research dissemination event
On 21st March 2025, the project team hosted a dissemination event at Makerere University to present and share their research findings. The event was presided over by Prof. Winston Tumps Ireeta, the Principal of the College of Natural Sciences (CoNAS) and Acting Deputy Vice Chancellor in charge of Finance and Administration at Makerere University. The event was attended by students, school administrators, as well as representatives from MakRIF and the Ministry of Science, Technology, and Innovation. In her address, the Project Principal Investigator (PI), Prof. Florence D’ujanga, emphasized the importance of sparking curiosity in students to encourage them to pursue scientific studies. “By making astronomy and space science more accessible and engaging, this project seeks to inspire greater interest in science education, ultimately benefiting Uganda’s long-term development in critical fields such as technology, engineering, and mathematics,” she explained.
On behalf of MakRIF, Dr. Mercy Rebekah Amiyo expressed appreciation to the research team for their invaluable initiative in promoting the study of science through astronomy. Dr. Amiyo praised the team’s dedication to making complex scientific concepts more engaging. She called upon the project team to secure property rights and take proactive steps toward the commercialization of the project.
In his remarks, the Guest of Honour, Prof. Winston Tumps Ireeta emphasized the importance of nurturing scientists who understand principles rather than simply memorizing frameworks. He emphasized the importance of early exposure for children to develop an appreciation for science. He expressed gratitude to the Government of Uganda for its continued support towards research activities at Makerere University.
Testimonies by students
Sharing their testimonies about the project, Jonathan Mugabi and James Tanzinge, both S.4 students at Makerere College School, expressed heartfelt gratitude for the opportunity it provided. They noted that the project had ignited a newfound passion for research, significantly expanding their interest in exploring scientific topics. Through their participation, they were introduced to essential scientific vocabulary, which has helped to deepen their understanding of complex concepts. Additionally, the project exposed them to cutting-edge technology, fostering a sense of excitement and curiosity about the role of innovation in science. As a result, both students have developed a strong desire to continue their studies in the sciences at a higher level, inspired by the hands-on experiences and knowledge they gained from this initiative.
Click on the link below for the pictorial of the dissemination conference;
https://drive.google.com/drive/folders/1Wv5xLOwiNe8Tc9uOWBpt9xvOtwffLHdo?usp=sharing
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