Veterinary & Biosecurity
Mak, Alfasan Sign Anti-Tick Vaccine Production MoU
Makerere University on Friday 19th March, 2021 signed a Memorandum of Understanding (MoU) with Alfasan Uganda Limited to facilitate production of test batches of the Anti-Tick Vaccine developed by the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB). The MoU was signed on behalf of Makerere University by the Vice Chancellor, Prof. Barnabas Nawangwe and on behalf of Alfasan by the Managing Director Dr. Stephen Birungi. The Principal CoVAB-Prof. John David Kabasa, Anti-Tick Vaccine Initiative Principal Investigator (PI)-Dr. Margaret Saimo-Kahwa and Acting (Ag.) Manager Intellectual Property Management Office (IPMO)-Canon Goddy Muhumuza signed as witnesses.
The Anti-Tick Vaccine Initiative is hosted under the Centre for Biosecurity and Global Health, CoVAB. According to the Prof. Kabasa, the Centre was one of the milestones endorsed by the University when the then faculty to college transition was proposed. “I am happy to report that the Centre is being vigorously supported by the Government to undertake activities of vaccine development together with other scientists.”
He thanked the Vice Chancellor always taking keen interest in the multidisciplinary programmes undertaken by the college with a view improving the livelihoods of both small and large scale livestock farmers. He equally lauded the CoVAB scientists for their efforts to develop the Anti-Tick Vaccine and stakeholders such as the Africa Institute for Strategic Animal Resource Services and Development (AFRISA), Centre of Tropical Medicine and the Ruth Keesling Wildlife Health, Research and Outreach Centre (RK_WHERE) for their support.
Unveiling the research challenge and solution, the PI Dr. Margaret Saimo-Kahwa noted that ticks as vectors for diseases like East Coast Fever are an economic threat to farmers with herds of exotic breeds, their crosses and increasingly, local breeds raised in a tick-free environment. Furthermore, common tick species in Uganda have developed resistance to acaricides used in spraying as a method of their control. This resistance is further exacerbated by acaricide contamination of the environment, leading to residues in animal products like milk and meat, which have implications on human health.
“Therefore, alternative methods like anti-tick vaccines that reduce the use of acaricides are urgently needed to protect the livestock sector that plays a role in poverty reduction and contributes at least 3.2% to Uganda’s GDP, which is equivalent to about 1 Trillion Uganda Shillings” said Dr. Saimo-Kahwa.
The efficacy of any innovation is measured by how well it has worked elsewhere. The Anti-Tick Vaccine Initiative therefore sought inspiration from Australia, where the first anti-tick vaccine was developed in the 1980s as well as Cuba where the vaccines have been used successfully for over 20 years. Gleaning further from Brazil, the team used biotechnology approaches to develop antigens that can target the ticks in Uganda.
“Testing of these molecules under laboratory conditions with funding from the Government of Uganda has been done” remarked the Principal Investigator before adding, “The next step is to test these molecules in clinical trials. However, the molecules should be manufactured under Good Manufacturing Practice (GMP) and not under laboratory conditions.”
Dr. Saimo-Kahwa at this point thanked the President, H.E. Yoweri Kaguta Museveni, whose advice led the research team to the GMP-certified Alfasan Uganda Limited. “These negotiations have been fruitful, leading to the drafting of a memorandum of understanding for production of test batches of the potential vaccine, with funding from Government of Uganda.”
Dr. Stephen Birungi a Makerere University alumnus from CoVAB was all praises for his alma mater and commended Prof. Barnabas Nawangwe for ushering in era of innovation in the short time he has served as Vice Chancellor. “If we are seeing a threat to the livestock industry, we need to act now to save the 20-30% of Uganda’s 15million head of cattle that we lose annually due to tick-borne diseases.”
He reassured all present that Alfasan, a private company certified for the production of veterinary biologicals, was fully committed to improving the livelihood of Ugandan livestock farmers by partnering with the Government of Uganda and institutions such as Makerere University.
“Alfasan as a factory that was born out of partnership between Uganda and Holland is ready to give the facilities that will convert this beautiful innovation from Makerere; once again proving that Makerere is not just a theoretical teaching institution but is ready to bring out those products that can change lives in our country” affirmed Dr. Birungi.
He thanked Makerere University for recognizing the need to produce homegrown vaccines, noting that imported batches tend become less efficacious after multiple applications due to varying protein compositions of the ticks in countries where the remedies originate and Uganda.
“It is therefore important that Government doubles the effort to support CoVAB and Makerere University so that we don’t only stop at this solution but go out and solve even bigger problems using research that has been proven such as this anti-tick vaccine” Dr. Birungi added.
Makerere University is home to a number of innovations, whose number keeps growing thanks to generous funding from the Government and other partners. In recognition of the need to translate these innovations into commercially viable products, the University introduced an Intellectual Property Management Office and appointed Canon Goddy Muhumuza as Ag. Manager. Guiding the MoU signing ceremony, Canon Muhumuza, who also doubles as Principal Legal Officer, made specific mention of the clause on “Ownership” clarifying that Makerere University shall own the patent of the vaccine.
“A new dawn is setting on Makerere University. Makerere University is becoming a truly international research university,” commenced the Vice Chancellor as he made closing remarks following the brief MoU signing and exchange ceremony.
He thanked Dr. Saimo-Kahwa for her great work and mentorship as shown by the constitution of her team, mainly made up of young people. The team is made up of Scientists; Dr. Olaho Mukhani William, Dr. Kokas Ikwap, Dr. Mukiibi Herbert, Dr. Ochwo Sylvester, Dr. Musadha Zachary and Mr. Peregrine Sebulime.
In order to study the life and breeding cycles of ticks, the Initiative included a specialist (Acarologist), Mr. Charles Ssekitto. Technicians who form part of the team include; Mr. Geoffrey Ssentamu, Mr. Nalumenya David, Ms. Namubiru Sarah and Mr. Abubaker Musoba. Mr. Gerald Brooks Musinguzi is in charge of Communication while Ms. Kaudha Rose is the Administrator.
The Vice Chancellor noted that the capacity to develop vaccines was evidence of attaining to the highest levels of research capacity and expressed great pride to learn that the team was completely Ugandan. He thanked the Government of Uganda for the heavily investing in research at Makerere University and reminded staff of their obligation to give back to the taxpayers by providing good accountability.
“I must thank the leadership of the college for the great work they are doing. Professor Kabasa is passionate about Makerere and Uganda and what we should be doing to develop our country” remarked Prof. Nawangwe.
Results from the trials conducted so far showed that the overall efficacy of the vaccine candidate proteins was 86% for R appendiculatas (the brown ear tick) that transmits East Coast Fever (ECF) and 53% for R decoloratus that transmits Babesiosis. “If this vaccine can reduce the burden of tick borne diseases, we will have through one single innovation made a huge contribution to solving one of Uganda’s biggest problems.”
Prof. Nawangwe thanked Alfasan Uganda Limited for being pioneers in implementing academia-private sector collaboration. “As we come up with more innovations and move towards being a research-led University, it is inevitable that we have to work with the private sector, and I thank Managing Director for this gesture… you are a good alumnus.”
This MoU marks the beginning of a long and mutually beneficial partnership between academia and the private sector. The Anti-Tick Vaccine Initiative intends to expand the immunization to include more animals and carry out a clinical trial to determine the appropriate dosage and schedule. Furthermore, the Anti-Tick Vaccine candidate proteins offer more opportunities to include other candidate vaccine proteins of other cattle diseases into the combination.
The event was moderated by the Principal Public Relations Officer, Ms. Ritah Namisango and the Communication Officer CoVAB, Mr. Gerald Brooks Musinguzi.
Article by Public Relations Office
Veterinary & Biosecurity
Makerere University and Partners Celebrate INSSPIRE Project Achievements in Evidence-Based Higher Education on Food Systems and Climate Action
By Harriet Musinguzi & Jacinta Nakaye
INSSPIRE, a flagship project housed at the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), has successfully concluded its three-year implementation journey with a final workshop held on Tuesday, 18th November 2025, at the Imperial Royale Hotel. The workshop brought together key stakeholders from leading universities across Europe and Africa to reflect on the project’s achievements, share lessons learned, and explore opportunities for future collaboration.
Over the past three years, the INSSPIRE Project has made significant strides in advancing research, innovation, and capacity-building, particularly in the areas of food systems and climate action. Through its initiatives, the project has contributed to strengthening academic programs and aligning them more closely with societal needs and the evolving job market.
Some of the notable achievements of the INSSPIRE Project include the comprehensive review and enrichment of the curriculum, ensuring that learning is not only academically rigorous but also practically relevant to societal needs and the evolving job market. In addition, the introduction of real-life learning labs has provided students with invaluable hands-on experience, enabling them to engage directly with community challenges and apply their knowledge in practical, impactful ways. The project has also pioneered the use of Collaborative Online International Learning (COIL), linking students with peers from other countries to foster cross-cultural exchange and collaborative problem-solving. This innovative approach has strengthened the connection between academia and society, equipping graduates to become solution-oriented leaders in addressing pressing global issues such as food systems and climate action.
Prof. Barnabas Nawangwe, the Vice Chancellor of Makerere University, was represented at the conference by Prof. Julius Kikoma, Director of Graduate Training. Delivering remarks on behalf of the Vice Chancellor, Prof. Kikoma commended the remarkable achievements realized through the strong partnership of multiple universities under the INSSPIRE initiative. He underscored the conference theme, “Advancing Evidence-Based and Inclusive Education for Food Systems and Climate Action,” as a powerful reflection of the project’s commitment to tackling global challenges through innovation, collaboration, and shared learning.
Prof. Nawangwe noted that the INSSPIRE Project, centered on innovation for sustainability and societal relevance, has successfully brought together universities from the Netherlands, Spain, Slovenia, Kenya, Uganda, Benin, and South Africa. Within this collaborative ecosystem, institutions have reimagined higher education to make it more inclusive, experiential, and responsive to pressing challenges such as food systems transformation and climate change.
Nawangwe noted that this transformation comes at a critical time when Africa faces immense challenges in food security and climate change. Uganda remains highly vulnerable, with floods and other climate shocks severely affecting communities and livelihoods. He emphasized that food systems are under pressure from rapid population growth, unsustainable practices, and environmental degradation, while climate change is already impacting nutrition and resilience. Universities like Makerere must rise to this challenge, he said, and that through initiatives like the INSSPIRE Project, Makerere University joined regional and international partners to generate evidence, influence policy, and drive innovation though solutions generated by students, researchers, and communities.
The Vice Chancellor expressed gratitude to Vrije Universiteit Amsterdam, the project’s lead institution, for fostering collaboration that has strengthened long-term partnerships between Makerere and universities in Europe and Africa. He praised this cooperation as a model of global academic partnership, where learning flows both ways and innovation thrives in diversity. He also thanked Erasmus+, the European Union, RUFORUM, FAO, national agencies, and research institutions for their support. Special recognition was given to CoVAB for providing an enabling environment, and to the dedicated Makerere INSSPIRE team led by Dr. Charles Drago Kato, whose leadership has been central to the project’s success.
Prof. Frank Norbert Mwiine, Principal CoVAB expressed the commitment of the college leadership in moving the INSSPIRE innovations forward, as demonstrated in the innovations in the department of Livestock resources and the continuous development of staff to broaden the teaching of these courses. He said the college would remain part of the network and appreciated INSSPIRE for the capacity-building initiatives for the staff of the college especially in the new pedagogical methodologies like the real-life lab.
Dr. Denyse Snelder from VU Amsterdam gave a broad overview of the project activities they engaged in, including the capacity development on evidence-based and inclusive education, strengthening the university to community collaboration, and inter-university collaborations. She highlighted the key achievements realized, which include sixty lecturers actively engaged, 850 students reached through enriched courses, Five Hundred community stakeholders engaged, establishment of community practice with Eighteen Universities in Africa and Europe under the umbrella, South to South and triangular cooperation.
The INSSPIRE Project aimed to prepare students in higher education for labor market success by equipping them with the knowledge and skills needed to drive food systems transformation and adapt to climate change, thereby contributing to sustainable growth.
Veterinary & Biosecurity
Urban Farming & Climate-Smart Practices: Makerere Researchers Explore Innovations at Kyakuwa Farm
A team of scientists under the collaborative research project “Building Capacity for Innovation and Advancement of Climate Smart Agriculture in East and Southern Africa (CICSA-E&SA)” recently visited Kyakuwa Farm, a model site for urban farming innovations. The visit provided valuable insights into practical climate-smart farming technologies that can strengthen resilience and reduce emissions in urban and peri-urban livestock systems.
The Climate-Smart Agriculture project is led by Makerere University in partnership with the Norwegian University of Life Sciences (Norway), Maseno University (Kenya), LUANAR, and DARS (Malawi), with funding from the Norwegian Agency for International Cooperation and Quality Enhancement in Higher Education (Diku). One of its objectives is to develop a Climate-Smart Agriculture (CSA) Platform to bring together key stakeholders to share experiences, promote proven CSA technologies, and build farmer resilience while minimizing greenhouse gas emissions.
The visit was led by Principal Investigator Dr. Nampanzira Dorothy Kalule from the Department of Livestock and Industrial Resources at the College of Veterinary Medicine, Animal Resources, and Biosecurity (CoVAB), Makerere University. She was joined by other scientists, including Prof. Vincent Muwanika, whose combined expertise enriched the engagement at Kyakuwa Farm. Together, the delegation emphasized Makerere University’s dedication to promoting urban farming and climate-smart agriculture through collaborative learning and knowledge exchange.
While at the farm, the scientists witnessed a number of climate-smart innovations that reinforce the sustainability of the Kyakuwa dairy system. These included silage made from excess sweet potato vines, hay produced from Paspalum grass during compound slashing, and hydroponic fodder cultivated as a nutrient-rich supplement. To address the persistent challenge of flies, the farm applies diatomaceous earth, an organic insecticide, both in the environment and mixed with feed. This integrated approach, they learned, enhanced animal nutrition, improved herd health, and maintained environmental hygiene.
Prof. Jolly M. L. Kabirizi, Executive Director of Kyakuwa Farm and animal research scientist at Valley University of Science and Technology, welcomed the Makerere University team. She showcased her sustainable urban farming model, highlighting dairy production supported by innovative feed, waste management, and climate-smart practices that reduce costs, empower youth, and promote community engagement. The farm places dairy production at its core, integrating innovative feed and waste-management practices that embody climate-smart agriculture. These strategies enhance productivity, optimize resource utilization, and minimize environmental impact, making the farm a replicable model for sustainable urban farming.
According to the scientists, Prof. Kabirizi’s standout innovation is her concept of “turning waste into wealth.” Instead of relying mainly on elephant grass like many dairy farmers, she introduced the use of assorted organic market waste as a sustainable feed source. By training vendors in waste recovery, she incorporates bean pods, sweet potato vines, and pineapple residues into her feeding program. These unconventional resources now form a major part of her dairy system, cutting feed costs, improving sustainability, and reducing organic waste in urban markets.
Prof. Kabirizi complements her waste-to-feed innovations with sustainable feeding technologies that reinforce Kyakuwa Farm’s resilience. The farmer produces silage from surplus sweet potato vines, hay from Paspalum grass during compound slashing, and hydroponic fodder as a nutrient-rich supplement. To tackle the challenge of flies, Kabirizi said she applies diatomaceous earth organically in both the environment and feed. This integrated system boosts animal nutrition, strengthens herd health, and maintains environmental hygiene, showcasing climate-smart agriculture in action.
Kyakuwa Farm highlights a climate-smart use of manure by transforming it into a valuable energy resource. Through solar drying, manure is converted into charcoal briquettes that offer households a cleaner, affordable alternative to firewood. This innovation reduces reliance on traditional fuels, eases pressure on forests, and integrates renewable energy into livestock management, showcasing how circular resource use strengthens sustainability and climate resilience in urban farming. In her closing remarks, after successful deliberations with the scientists, Prof. Kabirizi urged the visiting scientists to champion early retirement planning among farmers, drawing on her own rewarding retirement shaped by community training and mentorship. She has empowered households within and beyond Wakiso District through skills in urban dairy management, climate-smart feeding, and value addition.
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