Veterinary & Biosecurity
An Interdisciplinary approach addressing Ticks and Tick-borne Diseases of cattle in Uganda
Published
2 years agoon
By
Mak EditorBy Joseph Odoi
Globally, Ticks are the most important vectors of disease-causing pathogens in domestic and wild animals and tick-borne diseases (TBDs) are a major threat to both cattle and human health. Understanding the complex interactions within the microbiome is of great importance for understanding how tick-borne pathogens spread and cause disease.
Inspired by the need to generate evidence to inform policy around Tick borne Diseases, a team of researchers from Swedish University of Agricultural Sciences, Biomedical Sciences and Veterinary Public Health, Sweden, Makerere University, College of Veterinary Medicine, Animal Resources and Biosecurity, conducted a study to assess diversity of ticks and their Tick Borne Diseases (TBDs) in Uganda from 2017 to 2021.
The researchers organised a dissemination of the project results workshop to stakeholders from various sectors on 27th February, 2023 held at the Centre for Biosecurity and Global Health, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University.
Associate Professor Lawrence Mugisha, Co-principal investigator explained that the purpose of the workshop was to share the results of the different research outputs and discuss various ways to re-package the results for different target audiences and to influence policies for tick control strategies in Uganda.
Having set the scene for the workshop, Associate Professor Maja Malmberg, Principal investigator from Swedish University of Agricultural Sciences, Biomedical Sciences and Veterinary Public Health, Sweden provided a virtual overview of the Project tilted; Ticks and Tick Borne Diseases (TBDs) in Africa. She noted that the overall purpose of the project was to improve cattle health through increased understanding of the microbial community in cattle and ticks, by investigation of the microbial composition (microbiota) of ticks and how this affects transmission and disease development in cattle in Uganda. As part of the study, she noted that the research team were able to generate new knowledge on diversity of tick species, new viruses and highlighted public health implications of the findings. The project had a capacity building component through supporting masters and PhD students and several technical workshop during the project period.
Various presentations of the results from different studies under the project were made by the project investigators and the PhD student Dr. Steven Balinadi who successfully graduated in 2022.
Below are brief project results from the presentations made at the Workshop;
- A total of 15 different tick species were identified in the five study districts of Kasese, Hoima, Soroti, Gulu and Moroto representing different ecological zones. They also reported high tick burden on cattle from all the study districts. They found out the tick species R. appendiculatus (the brown ear tick), the vector for the causative agent for East Coast Fever (“Amashuwo”, “Amakebe”) was most common tick on cattle in all districts (51.79%) followed by A. variegatum (14.33%) and R. evertsi (8.23%) and continue to dominate tick distribution in Uganda. The team also found ticks that were not known to be in Uganda including Rhipicephalus afranicus that was recently described in South Africa and Rhipicephalus microplus, expanding its geographical zones found ion cattle in Gulu and Soroti districts.
- The team further identified 8 viruses from the blood of cattle suspected to be transmitted by ticks and mosquitoes belonging to 4 viral families (Flaviviridae, Peribunyaviridae, Reoviridae and Rhabdoviridae) and 6 genera (Hepacivirus, Pestivirus, Orthobunyavirus, Coltivirus, Dinovernavirus and Ephemerovirus) among 175 studied cattle. Four of the viruses were new and were tentatively named Zikole virus (Family: Flaviviridae), Zeboroti virus (Family: Reoviridae), Zebtine virus (Family: Rhabdoviridae) and Kokolu virus (Family:Rhabdoviridae). This contributes to the body of the new knowledge in the field of virology. However, they were quick to mention the public implications of all viruses and new viruses remains to be understood through more studies.
- Part of the research assessed cattle exposure to Crimean Congo Haemorrhagic Fever (CCHF) Virus a zoonotic disease of public health importance transmitted by ticks. The study found that 74% (500) of the studied cattle from five districts were exposed to the virus. This raises a big concern a potential source of infections to humans. This concern is verified by the results of investigating 32 CCHF confirmed human cases of the recorded outbreaks between 2013 and 2019. Of the 32 hospitalised human CCHF cases, 32% of them died. Most cases presented with fever (93.8%), followed by hemorrhage (81.3%), headache (78.1%), fatigue (68.8%), vomiting (68.8%) and myalgia (65.6%) and other symptoms. The researchers were able to characterise the CCHF viruses circulating in Uganda, a break through that can inform vaccine and diagnostic tool development.
- Further, looking at the ticks themselves using advanced technologies, ticks were found to carry several viruses most of the unknown and new. The team has at least found 20 new viruses in the ticks and the team will be conducting further studies to understand the implications of the so many viruses in relation to animal and human health.
The team presented potential Public Health Implications of their study results as:
• High diversity and burden of ticks infesting cattle in Uganda has potential for a high pathogen load
• Evidence for range expansion of some tick species; risk for disease emergence in naïve animal and human populations around the country
• Cattle in Uganda are harbouring numerous viruses including novel ones
• CCHF is widespread in Uganda, including where human cases have not been detected. And its endemicity does not overlap with the spatial distribution of Hyalomma ticks
Participants of the stakeholder’s dissemination workshop discussed the results and provided feedback. Out of the discussion, it was generally agreed and proposed that deliberate actions need to be undertaken if we are to address the current challenges posed by ticks and their tick-borne diseases. Participants emphasised the following areas that require immediate attention;
- The need for improved surveillance and diagnostic tools for emerging viruses in animals to prevent their transmission to humans.
- The need for the Government investment in advanced technologies and equipment for improved surveillance, detection, and rapid response to any emerging virus outbreak from ticks and their pathogens.
- There is need to understand the cultural and social context: Therefore, any policy or intervention aimed at preventing disease transmission should take into account the cultural and social practices of the communities involved.
- The government should engage with local communities, listen to their concerns, and incorporate their knowledge and perspectives in developing disease control policies.
- The government should prioritize research and development of strategies to control ticks and prevent tick-borne diseases in both humans and animals. This includes conducting awareness campaigns, developing policies, and providing resources to prevent tick infestation and tick-borne diseases.
- Employ One Health approach: that considers the interactions between human, animal, and environmental health.
- More funding and support for tick-borne disease research and control programs in Uganda and other high-risk areas.
- Integration of livestock and human health surveillance and control measures to prevent the transmission of tick-borne diseases.
- Development of community-based tick control strategies that incorporate local knowledge and practices to increase their relevance and effectiveness.
- Collaboration between government agencies, researchers, and communities to implement effective tick-borne disease control strategies.
In his remarks at the engagement, Dr. Kenneth Mugabi, a Senior Veterinary Officer at Ministry of Agriculture, Animal Industry and Fisheries congratulated the team of researchers for undertaking the value based research adding that it will help inform policy to address ticks and tick borne diseases in the country. He equally noted the urgent need for more innovation to discover and develop vaccines, therapeutics and diagnostics options to respond to the increasing challenges of ticks and tick-borne diseases. Additionally he equally thanked the study funders for partnering with Makerere University to undertake the study.
Dr. Ekwaro Obuku from Makerere University College of Health Sciences in his emphasized the importance of researchers tailoring research in a way that it speaks to policy makers adding that researchers should use all avenue to influence policy initiatives for public good. He equally proposed for the need for researchers to have a data bank around Ticks and Tick-Borne Diseases.
The stakeholders’ workshop attracted over 70 participants ranging from government officials, academia, media, farmers and one- health officials among others.
Key issues discussed by participants include; Policy brief to address Tick and Tick-Borne diseases, Development of community-based tick control strategies that incorporate local knowledge and practices,one-health approach in addressing ticks and Tick-Borne diseases ,Importance of engagement with local communities affected by ticks and Tick-Borne ,the need for effective communication by researchers to influence policy, need to develop diagnostic tools and model based surveillance for early detection and early warning about Vector borne diseases among others
PROJECT TEAM
Principal investigator: Dr. Maja Malmberg – Swedish University of Agricultural Sciences, Biomedical Sciences and Veterinary Public Health, Sweden
Co-PI in Uganda: Assoc. Professor Lawrence Mugisha – Makerere University, College of Veterinary Medicine, Animal Resources and Biosecurity, Uganda and Ecohealth Research Group, Conservation & Ecosystem Health Alliance, Uganda
PhD student: Mr. Stephen Balinandi – Uganda Virus Research Institute, Uganda and Makerere University, College of Veterinary Medicine, Animal Resources and Biosecurity, Uganda
Professor Erik Bongcam Rudloff – Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics, Sweden
Dr. Erika Chenais – National Veterinary Institute, Sweden
Assoc. Professor Klara Fischer – Swedish University of Agricultural Sciences, Department of Rural and Urban Development, Sweden
Dr. Lidia Chitimia-Dobler – Bundeswehr Institute of Microbiology and University of Hohenheim, Department of Parasitology, Germany
Dr. John Pettersson – Uppsala University, Department of Medical Biochemistry and Microbiology, Sweden
Dr. Juliette Hayer – Swedish University of Agricultural Sciences, Department of Animal Breeding and Genetics, Sweden
Professor Mikael Berg – Swedish University of Agricultural Sciences, Biomedical Sciences and Veterinary Public Health, Sweden
Dr. Giulio Grandi – Swedish University of Agricultural Sciences, Biomedical Sciences and Veterinary Public Health, Sweden
Assoc. Professor Ingrid Hansson – Swedish University of Agricultural Sciences, Biomedical Sciences and Veterinary Public Health, Sweden
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Veterinary & Biosecurity
Strengthening CoVAB’s Partnership with the National Livestock Resources Research Institute (NaLIRRI)
Published
4 weeks agoon
December 19, 2024The College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB) and the National Livestock Resources Research Institute (NaLRRI) agreed on the urgent need to formalize their relationship in the area of skilling, training, joint research activities, supervision, and joint grant writing. The two institutions are looking for ways to mutually benefit from each other’s strengths and expertise for improved productivity in their mandates leading to significant advancements in livestock research and education.
The staff of the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), led by Principal Prof. Frank Norbert Mwiine, visited the National Livestock Resources Research Institute (NaLRRI) in Nakyesasa on Tuesday, December 17th, 2024. They were welcomed by the Director of Research, Prof. Samuel Majalija, who, along with his staff, conducted a guided tour of the institute’s facilities and enterprises to gain learning experiences. The purpose of the visit was to forge a formal partnership between the two institutions in the fields of teaching, research, and outreach.
In his welcome remarks, Prof. Samuel Majalija, formerly a Deputy Principal of CoVAB, noted that NARO values collaboration and synergy and explained that all the ongoing work at NaLRRI/NARO was rooted in both local and international partnerships, including those with Makerere University. He said the visit by the college leadership and staff was no mean achievement for NaLRRI/NARO, but a gesture of continued relationships between the two institutions.
During a meeting held after a tour of various enterprises ongoing at NaLRRI, Prof. Samuel Majalija emphasized the pivotal role of scientists in enhancing the country’s productivity. Lack of written documentation hampers knowledge transfer he observed and stressed the necessity of creating simple Standard Operating Procedures (SoPs) for every enterprise to instigate change nationwide. He expressed concern that despite being Uganda’s only livestock research institute, and the time he has been in the office of Director of Research, he had not seen any CoVAB students interning at NaLRRI. He challenged the college leadership to ensure that CoVAB students transition from theory to practical teaching and learning. Students need to be encouraged to gain hands-on experience, which is crucial for driving meaningful changes. Additionally, Prof. Majalija mentioned that NaLRRI/NARO was open to collaboration, with highly trained staff ready to engage with CoVAB students through Guest Lectures and skill-building initiatives. He emphasized the importance of Makerere University opening its doors to allow the research institute to tap into its extensive expertise.
Prof. Frank Norbert Mwiine, the Principal of CoVAB, acknowledged the warm welcome extended to CoVAB by the Director and staff of NaLRRI/NARO. He noted that the Makerere Strategic Plan 2020-2030, provides for a shift towards becoming research-led with increased emphasis on postgraduate training. Prof. Mwiine mentioned that Makerere benefits from a 30 billion research grant through MakRIF and highlighted ongoing collaborations with NARO, citing activities on the CoVAB land in Nakyesasa, which was originally part of NARO land. He said some NARO and Makerere University staff have in the past published jointly specifically in the field of livestock research and that both institutions were receiving funding through the Ministry of Science and Technology for vaccine development and emphasized the need for greater synergy and a convergence zone. Prof. Mwiine further stressed the need for continued collaboration with staff at NARO especially in student supervision and research publication.
The CoVAB Deputy Principal Assoc. Prof. James Acai Okwee, presented an overview of the ongoing research activities, challenges, and proposals for enhanced collaboration with NaLRRI/NARO. He outlined the existing research capacity in areas such as zoonotic pathogen screening for both human and animal infections, and the RTC’s work in researching ticks and tick-borne diseases. He also highlighted ongoing work at the Centre for Biosecurity and Global Health, which he said was leading the vaccine development efforts at CoVAB. Dr. Okwee noted that CoVAB acquired land in Nakyesasa in collaboration with NARO, and it was one of the areas where the college was undertaking activities like the livestock demonstration farms supported by the Korean government.
The Deputy Principal highlighted several challenges, faced by the College of Veterinary Medicine, Animal Resources, and Biosecurity including unfunded student research, which leads to delayed completion, dropout, and lack of depth. He also pointed out the inadequate infrastructure that requires refurbishing and the unsustainable project-based approach to research, as opposed to a program-based approach. He criticized the ivory tower model, where training is disconnected from research and practice. Additionally, he noted that the college has a large concentration of 140 underutilized scientists.
The CoVAB team was given a tour of the labs, where they observed the state-of-the-art equipment and demonstrations in the Nutrition Lab. They also visited the Pasture field, where Research Officer Allen Molly led the team through various demos of pastures and legumes. These included both Indigenous varieties from different regions of Uganda and improved varieties like sogmaize, highlighting their efficacy for milk and beef production. Also visited was the Aflasafe facility which undertakes monitoring of the safety inclusive of the analytical platform used for quantifying the different contaminations in food and beef and developing bio-control products to counteract the aflatoxins. At the Dairy establishment, the visiting CoVAB team was conducted around the Zero waste infrastructure, right from the care and feeding of cows themselves to the technologies issued in processing dung into gas and other bye by-products including soap, shampoo, and manure among others. Also visited was the anti-tick Vaccine facility which is undergoing expansion and will eventually undertake massive vaccine production of Livestock vaccines which is already developed.
As a way forward, it was also agreed that the College of Veterinary Medicine, Animal Resources, and Biosecurity was bound to benefit from the high expertise of the staff at NARO by not only allowing them to teach at Makerere University but also enabling them to involve more of the CoVAB students in the NaLRRI/NARO research programs. The partnership would also enable the two institutions to make accessible all available equipment and facilities for use across the board as far as it is possible as well as harmonize training at master level/research.
Veterinary & Biosecurity
Mak Field Day Training on livestock feed Climate-Smart Innovations conducted in Buwama
Published
2 months agoon
November 22, 2024A team of scientists and students from Makerere University convened at Our Lady of Assumption Mitala Maria Parish in Buwama where, together with farmers from the surrounding area undertook a practical demonstration of improved silage-making technologies aimed at faster animal feed production. The outreach activity was aimed at addressing the challenge of low production in terms of milk and meat from livestock, which was attributed to low quantity and poor quality of feeds especially during the dry season, coupled with the poor production systems with limited land–intensive systems of production in the face of climate change.
The farmer field school event held on Wednesday 20th November 2024 was organized under the theme; Stakeholder Platform: Collaborative Knowledge Co-Creation and Sharing for livestock feed Climate-Smart Innovations in Uganda. It was one of the four-year collaborative research project activities titled, “Building Capacity for Innovation and Advancement of Climate Smart Agriculture in East and Southern Africa” (CICSA-E&SA). This collaborative research project is implemented by Makerere University in partnership with the Norwegian University of Life Sciences (Norway), Maseno University (Kenya), and LUANAR and DARS (Malawi), funded by the Norwegian Agency for International Cooperation and Quality Enhancement in Higher Education (Diku)
The Principal Investigator, Dr. Dorothy Nampanzira Kalule, who is also the head of the Department of Livestock and Industrial Resources (LIR) at the College of Veterinary Medicine Animal Resources and Biosecurity (CoVAB) led the team that comprised Dr. Herbert Mukiibi from CoVAB, Prof. Vincent Muwanika from the College of Agricultural and Environmental Sciences (CAES) and Dr. Esaete Josephine from the College of Education and External Studies (CEES).
In her remarks, Dr. Nampanzira observed that because of climate change, the country particularly the farming communities was experiencing challenges in sustaining productivity and in getting adequate feeds for the livestock in the dry spells. We are looking for innovations that can sustain production she said, while emphasizing the fact that several useful practices from indigenous knowledge could be developed further for the benefit of many others. She said as scientists, they were going to the communities to look out for such practices, have them validated, and thereafter build capacity about these practices. Silogist, the technology used in making silage was developed through such on-farm experiences to preserve pastures and ensure the availability of feeds, especially in the dry season, she noted.
One of the pillars of the project, Building Capacity for Innovation and Advancement of Climate Smart Agriculture in East and Southern Africa” (CICSA-E&SA), is the creation of a stakeholder platform involving various players in the livestock value chain, inclusive of researchers, farmers, politicians, and the church. The outreach conducted in Mitala Maria was in line with the project’s objectives of developing a Climate Smart Agriculture (CSA) platform that includes key stakeholders engaged in activities and initiatives that promote Livestock CSA practices and technologies that limit greenhouse gas emissions from Livestock. Through such fora, the stakeholders would deliberate and establish why, despite the number of innovations and technologies developed by scientists at Makerere University, farmers were still engrossed in poverty as evidenced by the lack of feeds during the dry season. The stakeholder engagement was expected to find ways of transferring these technologies to the people for adoption, leading to improved livestock productivity said, Dr. Nampanzira while explaining why the university reached out to the communities through Mitala Maria Catholic Church.
Dr. Herbert Mukiibi, the brain behind Silogist who is a veterinarian by training with an interest in the microbiology field said throughout his practice he has been exposed to the challenges faced by farmers and using literature from research at Makerere University, together with the farmers, through action research, he has come up with solutions to the existing problems faced by farmers. He noted a lot of expertise has been written in many forms of publications which unfortunately was not being used by the farmers. As a university, we were finding ways of packaging such messages through such demonstrations to enable hands-on experience and tooling amongst the farmers.
‘In Mitala Maria, we found them with a non-commercial farm, shared the technologies that were piloted in other communities, and supported them make the farm commercial. We are here to look at what was done and enable other farmers to learn that they can turn around their farms and go commercial amidst the climate change era where farmers are increasingly getting confused with low crop and animal yields because of the scarcity of resources’ said Dr. Mukiibi. He pointed out other challenges faced by farmers like lack of nutrient recycling caused by people taking products from the farm and not having a loop of nutrients coming back to the farm leading to depletion of soils for which he said, he had come up with nutrient recycling tools so that farmers can realize high yields as it used to be.
Prof. Vincent Muwanika who explained his background and linkages with the Sustainable Future Global Network and the Stewardship Institute of Environment appreciated the efforts by Mitala Maria parish which was engaged in several enterprises including livestock farming, banana plantations, eucalyptus growing, and others. He said as a faith-based institution, it was the mandate of the institution to embark on empowering their faithful with the needed knowledge and skills necessary for them to generate household and ultimately church income. He said allowing the farm to be used as a demonstration for others to come and learn was important in supporting the individual household efforts to gain the skills needed to undertake enterprises for income generation.
Several livestock farmers and those with intentions of embarking on the trade participated in the day’s activities drawing valuable learning experiences. ‘I have found silage very user friendly because the cows like it very much, secondly, it makes the feed readily available’, said the cattle attendant at the Mitala Maria farm that hosted the farmer field school where the demonstration was conducted. He said he benefited from the training to further understand the process of making silage and was optimistic that he was going to do the same in his own home where he is rearing cattle.
The head of the laity Mitala Maria Mr. Bwanika informed the gathering that although the farm had been in existence for a long time, it had deteriorated. He commended the team from Makerere University who came on board to support the revitalization of the farm using several technologies according to the strategic plan of the parish. He said, with the advice of the university staff, they were able to plant the pastures, restock the farm, and were on the right path to make it a model farm for the rest to learn from.
Building Capacity for Innovation and Advancement of Climate Smart Agriculture in East and Southern Africa” (CICSA-E&SA) aims to develop a higher education multi-disciplinary curriculum in agriculture and economics, targeted to building knowledge and scientific capacity for innovation and advancement of Climate-Smart Agriculture (CSA) in East and Southern Africa through long-term partnerships between and among NMBU and four institutions in Kenya, Malawi, and Uganda.
Veterinary & Biosecurity
Mak Hosts INSSPIRE Project Workshop on Enhancing Evidence-Based Education on Food Systems and Climate Change
Published
3 months agoon
October 24, 2024Written by Jacinta Nakaye
Kampala, Uganda – October 14, 2024 – Makerere University’s College of Veterinary Medicine, Animal Resources and Biosecurity (COVAB) is hosting a five-day Training of Trainers workshop for the Collaborative Online International Learning (COIL) model. This is part of the Innovation for Sustainability and Societal relevance (INSSPIRE) project, which focuses on enhancing evidence-based education in food systems and climate change.
The workshop that brought together partners and stakeholders from various higher education institutions across Southern and Northern Africa to brainstorm innovative strategies for addressing these pressing global challenges.
During the opening session held at the Centre for Biosecurity and Global Health (CEBIGH) at CoVAB, stakeholders demonstrated their progress in implementing Real Life Learning Labs (RLLL), an experiential learning approach designed to foster interdisciplinary collaboration on real-world development projects. These labs aim to tackle relevant issues in agriculture, industry, and society by equipping students with practical skills and problem-solving capabilities.
Associate Professor Robert Wamala, Makerere University’s Director of Research and Graduate Training delivered a keynote address on behalf of Vice Chancellor Makerere University Prof. Barnabas Nawangwe. He emphasized the severe impact of climate change on global food systems, particularly in vulnerable regions. “Climate change disrupts food systems globally, aggravating food security by impacting agricultural production through extreme weather events and shifting rainy seasons,” he stated. Prof. Wamala highlighted the need for transformative solutions that address the intertwined issues of food security and environmental degradation, which was on the areas to be addressed through the intervention.
The INSSPIRE project aims to stimulate innovative education and build inter-university capacity through international partnerships. By focusing on capacity building in higher education, the initiative supports staff development at participating universities in Kenya and Uganda thereby enhancing the delivery of educational modules on food systems and climate change.
Dr. Kato Charles Drago from CoVAB who is the team lead for the INSSPIRE project at Makerere University, coordinated the workshop, which attracted participation from institutions such as South Eastern Kenya University, the Institute for Innovation & Development of the University of Ljubljana, Mbarara University of Science and Technology, Maseno University, the University for Development Studies (UDS) in Tamale, Ghana, and the University of Energy and Natural Resources (UENR) in Sunyani, Ghana.
Prof. Frank Norbert Mwiine, the Principal of COVAB, in his address to the participants noted that Uganda’s economy largely depends on agriculture and the sector supports several families and employs a big part of the population both formally and informally including graduates from Makerere University across several disciplines. He said food systems in the country were rapidly evolving as a result of population demands amidst the increasing challenge of climate change. ‘We are glad that the INSSPIRE project plans to address this gap by strengthening food systems and adapting them to the challenges of climate change, he said.
Prof. Mwiine appreciated the support that CoVAB will receive from the project in enriching curricula for two courses under the Bachelor of Animal Production Technology (BAP) by building the capacity of staff to deliver modules on food systems, which he said, would make the graduates competitive in the ever-changing job market. The training of staff in curriculum enrichment and new course delivery approaches like the Collaborative Online International Learning (COIL), and gamification will help improve teaching and aid student’s interest and understanding of agriculture-based courses. He observed. While addressing himself on the real life-learning labs pioneered by the INSSPIRE project, he said the model will facilitate students to acquire practical skills and hence enhance their relevance in the community as the students and staff support communities to identify real-life challenges and tackle them holistically. He reaffirmed the commitment of the college leadership in moving these innovations forward, as demonstrated and that the college was ready to engage further in resource mobilization drives to propel the innovations forward.
As the workshop unfolds over the coming days, participants will deliberate on innovative strategies to transform food systems and advance climate change education, underscoring the critical importance of multidisciplinary approaches in fostering sustainable development.
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