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Assoc. Prof. Annettee Nakimuli wins US$1M grant for Maternal Health Research

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Associate Professor Annettee Nakimuli, Dean – School of Medicine has been awarded US$1M grantfor Maternal Health Research from the Gates Foundation Calestous Juma Science Leadership Fellowship. The five-year grant, entitled “Enhancing prediction of adverse pregnancy outcomes in Africa through partnerships and innovation” will focus on Great Obstetrical Syndromes (GOS), such as pre-eclampsia, preterm birth, stillbirth, intrauterine growth restriction;to help develop context-relevant interventions for prevention and treatment.

This is a major research project because GOS is a major killer in sub-Saharan Africa accounting for 60% of the deaths of mothers. Maternal mortality in Uganda remains high in the region at 336/100,000 live births which is approximately a 14-seater bus of women dying per day.

Dr. Nakimuli, a graduate of Makerere University College of Health Sciences, is an internationally-recognized research leader in maternal health for Africa. Her work can be traced back to 2006 when she was appointed an Assistant Lecturer in the Department of Obstetrics and Gynaecology, Faculty of Medicine, Makerere University. She then enrolled for PhD in 2009 to investigate how KIR and HLA-C genetic variants contributed to the pre-eclamptic risk in Ugandans which was the first genetic case-control study of pre-eclampsia in indigenous Africans – despite African ancestry being a predisposing factor to pre-eclampsia. She concluded that African women are at greater risk of preeclampsia than other racial groups. Dr. Nakimuli has researched extensively on maternal health, mentored young scientists and supervised manymasters and PhD students.

She will establish a cohort study of 4000 healthy pregnant women at Mulago and Kawempe Hospitals in Kampala, Uganda will be conducted where detailed clinical, biological and demographic information from mothers throughout pregnancy and from their babies at the time of birth will be collected. The study has potential to shed light on determinants, mechanisms and solutions for the excess burden of maternal and perinatal morbidity and mortality in SSA and for women with African ancestry elsewhere in the world. This study builds on Dr. Nakimuli’s project where she is investigating predictors of pre-eclampsia in a cohort 1,500 healthy pregnant women; supported by the Future Leaders–African Independent Research (FLAIR) fellowship project funded by the Royal Society through the African Academy of Sciences.

Some of the products from the grant/study include: i) the biobank from this research will provide an important resource for future research studies. ii) build capacity for African scientists to solve problems of the Africa continent other than dependence on foreign experts iii) develop regional partnerships iv) multidisciplinary research where scientists from various areas work together.

Dr. Nakimuli expressed her appreciation for the opportunity given to her by the Gates Foundation to undertake the study as well as the support from colleagues at College of Health Sciences and Makerere University. She also highlighted the work accomplished through partnership with scientists at the Department of Obstetrics and Gynaecology, University of Cambridge, U.K headed by Prof. Gordon Smith.

Zaam Ssali is the Principal Communication Officer SoL & MakCHS

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Boy Children Report More Physical & Emotional Abuse

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Men in the intervention group during the Parenting for Responsibility (PfR) project training session.

By George Kisetedde

On 3rd August, 2022, the CHDC (Child Health and Development Centre) disseminated study findings from one of the research studies carried out at the centre. These findings were presented under the title,“The Prevention of Violence against Children and Women: Baseline and Implementation Science Results from Parenting Cluster Randomised Trial.” Moderated by Dr. Anthony Batte, a lecturer at CHDC. Study findings were presented by Joseph Kahwa, the trial manager of the Parenting for Responsibility (PfR) project, under which this study falls.

Kahwa described PfR as a community based parenting programme delivered to both male and female parents. This programme aims to improve parenting skills, prevent violence against children, and to improve spousal relationships.

Findings from the study

Findings from this study showed that parents maltreat boy children more than girl children. The boys reported more emotional and physical violence than girls. Furthermore, the boy children reported that male caregivers specifically, maltreat them more. On the other hand, the girl children reported more sexual violence from caregivers than boys. On the whole, the children reported that female caregivers emotionally and physically abused them more compared to male caregivers.

More findings, according to Kahwa, showed that 46.5% of parents in Amuru can provide their children with soap to wash, 44.5% can provide school fees, 44.4% can provide school materials, 44.2% can provide new clothes, 43.3% can buy school uniform, and 35.9% can provide a pair of shoes.

How the research is conducted

The study is divided into 16 group sessions. The first 9 sessions are single sex, that is, male caregivers and female caregivers train separately. The next 7 sessions are mixed with male and female participants combined during training.

A mixed group parenting session for both men and women.
A mixed group parenting session for both men and women.

Kahwa explained that this programme was initiated to deal with VAC (violence against children) and IPV (intimate partner violence). These two vices are closely linked and have a significant impact on how children turn out.

Kahwa added that the PfR research programme aims at addressing the four major factors that may lead to VAC/IPV. These include; poor parental bonding, harsh parenting, unequal gender socialisation and spousal relationships.Poor parental bonding refers to the absence of a healthy close connection between a parent and their child. When a parent and child are not close, the parent may lack empathy for the child and the ability to perceive and respond to their child’s needs. When this bond is weak, a parent is unable to appreciate a child’s needs and can end up being unrealistically tough, which results in harsh parenting. Unequal gender socialisation generally refers to the different expectations that parents have of their children depending on their gender-male or female. The quality of the spousal relationship between parents also affects a child’s life. These four areas are what the parenting sessions concentrate on during the training.

The PfR study employed a cluster randomised controlled trial (RCT) design. Male and female caregivers were recruited from cluster villages in the Wakiso and Amuru districts in Uganda. One child aged 10 to 14 per household was randomly selected and assessed.

The caregivers were divided into two groups; the intervention group and the control group. The intervention group underwent all the 16 sessions of the training while the control group underwent a 2 session lecture on parenting. The impact of the PfR intervention was then ascertained by comparing baseline and endline results (or the before-and-after experiences of parents). The study participants were from 54 Villages selected in both Amuru and Wakiso districts. 108 caregiver groups (54 groups per intervention)were selected. This resulted in 2328 parents recruited and 886 children.

In conclusion, Mr. Kahwa said that maltreatment is still prevalent in the population. Generally, the PfR programme was well-received by parents and it had ad good attendance from parents. The programme also registered good male engagement. The peer facilitators who were recruited also had great potential in expanding the PfR programme at community level.

This study was conducted by Dr Siu Godfrey as the Principal Investigator. Other members of the team included Carolyn Namutebi, Richard Sekiwunga, Joseph Kahwa, Dr Betty Okot, and Martha Atuhaire. They were supported by the Director from CHDC, Dr. Herbert Muyinda and the CHDC Finance & Administration team. The team from Glasgow & Oxford Universities in the UK included, Prof Daniel Wight, Dr Jamie Lachman , Francisco Calderon and Dr Qing Han. On the other side, the team from the SOS Children’s Village from Gulu and Wakiso included, Rachel Kayaga, Sindy Auma Florence and Godfrey Otto.

Contact: George Kisetedde – kisetedde@gmail.com | Edited by Agnes Namaganda – agnesvioletnamaganda@gmail.com

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Makerere Medical Journal: Golden Jubilee Edition 2022

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Cover Page of the Makerere Medical Journal Golden Jubilee Edition 2022.

It’s with great pleasure that I welcome you to the Golden Jubilee edition of this phenomenal journal. Yes, The Makerere Medical Journal marks 50 years of publication with this year’s edition and all this has been made possible by the endless efforts and contributions of the Makerere University College of Health Sciences Staff and students because without your research submissions and financial support, the journal wouldn’t have made it this far. To you reading this, thank you for contributing to the sustainability of this great project, year in year out.

Here’s a quote to ponder on as you delve into this year’s well-crafted articles and it’s by Zora Hurston (1891-1960), “Research is formalized curiosity. It is poking and prying with a purpose.” And doesn’t that just define our purpose as researchers?!

This edition’s articles cover pertinent topics ranging from Antimicrobial Stewardship, COVID-19 interventions, Oral Health amongst others. It also features student projects, write-ups on student-led organizations and societies that are making a difference in the life of a health sciences’ student and many more interesting writings. Featured in this issue are international manuscripts from countries like Nigeria and we were also honored to work with other universities within the country and feature some of their students’ articles.

I would like to extend my most sincere gratitude to my team of editors that engaged in a rigorous peer review process to ensure that the articles published are up to standard. As the editorial team, we are quite pleased to see the number of undergraduates involved in research steadily increasing and all the efforts that have been put in by the different stakeholders to see this happen are commendable.

With that said, I hope you enjoy every second of your read!!!

LINDA ATULINDA,
MBChB IV

EDITOR-IN-CHIEF,
Research and Writers’ Club 2021-2022

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Call for Applications: HEPI Masters Support Fellowship

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Panelists L-R: Professor Elsie Kiguli-Malwadde, Professor Francis Omaswa, Professor Jehu Iputo and Professor Joel Okullo at the HEPI-ACHEST Health Professions Education Symposium, 17th June 2022, Makerere University.

Applications are invited for the Health Professional Education Partnership Initiative (HEPI-SHSSU) Masters fellowship programme support from postgraduate students of:

  • Makerere University College of Health Sciences (MakCHS)
  • Kabale University School of Medicine
  • Clarke International University
  • Faculty of Health Sciences, Busitema University

The programme will support graduates in their final year of training leading to the award of a Masters degree on any of the Master’s graduate training programs at the stated University for a maximum of 19 successful candidates.

The closing date for the receipt of applications is 30th September 2022.

Inquiries and Applications must be submitted to hepishssu@gmail.com

See attachment for more details 

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