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The 2020 COVID-19 Non-Pharmaceutical Containment Measures – Adherence and Impact on Livelihoods in Rural Uganda

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By Dr. Dan Kajungu and MUCHAP/IMHDSS Team

Uganda is currently experiencing a second wave of the COVID-19 pandemic with an upsurge of cases. The country registered an 81% increase in the number of COVID-19 cases between March and April 2021, which indicates resurgence or another wave in the pandemic. From 200 cases per day in April, now the country is recording over 500 cases per day. The vaccines uptake has improved only recently, and the population has ignored the Ministry of Health (MoH) Standard Operating Procedures (SOPs) meant to contain transmission. Since March 2021, when the COVID-19 AstraZeneca vaccine was introduced, about 541,569 persons have so far been vaccinated.

On 6th June, new control measures were announced to mitigate the transmission. The Makerere University Centre for Health and Population Research (MUCHAP) which runs a longitudinal population-based cohort of Iganga and Mayuge districts (Iganga Mayuge Health and Demographic Surveillance Site) conducted a community survey to understand how citizens responded to the non-pharmaceutical interventional measures, and the impact on their livelihood. This survey was part of the routine community surveys that a typical health and demographic surveillance site conducts to understand the population dynamics in population cohorts. The hybrid survey involved about 2,000 households in rural and peri-urban settings using a questionnaire that adopted some questions from the Wellcome Trust COVID-19 tool. It was a hybrid of on-phone and physical interviews conducted between July and August 2020 right after the relaxation of restriction in Uganda. Community based surveys provide information on what to expect when piloting and implementing interventions in populations. In addition to the demographic and household characteristics, questions sought to understand the extent of community adherence to COVID-19 control measures and probed about the impact on socio-economic and access to health services.

Adherence to preventive measures: The survey found that 94% of the respondents adhered to COVID-19 non-medical control measures that were enforceable by security personnel. It was different for non-pharmaceutical measures that were largely dependent on individual enforcement or discipline and this averaged at 43% of the respondents. Six in ten respondents reported doing most of their work from home and half (50%) avoided seeking medical care at health facilities during lockdown.

The non-pharmaceutical guidelines included using preventive actions like social-distancing, hand washing with soap, the use of alcohol-based hand sanitizing gels as well as wearing of face masks. Citizens were encouraged to stay at home with the exception of essential workers who rendered critical services. Some community members could not adhere, not because they do not take it as a priority but because of the cost implications.

Socio-economic impact: There was change in the living arrangement in 12% of the households mostly because someone moved out or into the household. Community members reported a reduction (64%) in the income for household members with some experiencing a complete stop in earnings (6%). Residents in rural settings reported more reduction in income compared to Peri-urban residents (78% vs 74%). There are seemingly unique circumstances that need to be considered as interventions and decisions are made. For instance, it should not be surprising that a household cannot afford to have a bar of soap, a face mask, an alcohol-based hand sanitizing gel and social distance because of the living structures. In some cases, even accessing water is a luxury for some homes. There are some homesteads that are unable to grow food or earn an income from selling cash crops because they leased their pieces of land for large scale sugarcane growing 3 or 4 years ago, with just a house and a few feet of compound to spare. Unfortunately, such individuals have no access to social media where they can express their predicament.

The survey further found out that during the 2020 lockdown period, there was a general increase in violence against men, children, and women. There were cases of child neglect as well as marital problems. The survey found that 53% of the respondents reported increase in marital problems, while violence against women during the lockdown was reported by 51% of the respondents and was more common among rural residents compared to their Peri-urban counterparts. Residents could not access what they considered essential needs like transport and education services, which were directly affected by government directives and other community services. Communication was the most affected essential service reported.

Access to Health Services: 26% of the interviewed community members who were on daily medication due to a chronic or long-term condition reported running out of drugs during lockdown. Non-affordability due to the cost was the main reason in 54% of respondents, while 19% reported cases of stock-outs at both public and private health facilities and 10% were restricted by lockdown measures.

In another review of the immunisation records at Busowubi Health Centre III in Iganga district, it was clear that during the lockdown, utilisation of immunization services was severely affected (manuscript is undergoing peer review). Children did not complete their scheduled vaccine doses which calls for catch up vaccination drives. People could not go to health facilities because of fear of acquiring infection and restricted movements of boda-boda.

Please see Downloads for the detailed report.

Mark Wamai

Research

The Uganda Higher Education Review Vol. 12, Issue 1

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The cover page of the Uganda Higher Education Review Vol 12, Issue 1. NCHE, Kampala Uganda, East Africa.

The National Council for Higher Education (NCHE) is mandated under Section 4(b) of the Universities and Other Tertiary Institutions Act 262, to promote and develop the processing and dissemination of information on higher education for the benefit of the public. In line with this mandate, NCHE has consistently advanced scholarly discourse in higher education through The Uganda Higher Education Review Journal, published semi-annually in May and November.

It is my privilege to present to you Volume 12, Issue 1 (November 2024) of the journal, now available electronically via DOI: 10.58653 and with ISSN 1813-2243 (print) and 2958-5473 (online). The articles in this issue embody a profound commitment to rigorous inquiry, intellectual curiosity, and scholarly excellence.

This edition explores critical themes, including:

  1. Financing and Investment in Higher Education.
  2. The Adoption of Emerging Technologies in the Digital Transformation of Higher Education.
  3. Improving Access and Inclusivity in Higher Education in Uganda: Addressing the Nation’s Low Gross Enrolment Ratio.
  4. The Role of the Private Sector in Enhancing Graduate Skills and Employability through Technology Innovation.

I sincerely appreciate the contributors whose unwavering dedication to their fields has enriched the publication. I also acknowledge the exceptional efforts of the authors, NCHE staff and Management, the editorial team, and the reviewers. Their expertise and commitment have been instrumental in ensuring the quality and integrity of the research presented in this volume.

Professor Mary J. N. Okwakol
EXECUTIVE DIRECTOR/EDITOR-IN-CHIEF

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Natural Sciences

CARTA Fellow Anywar Attends 2024 World Science Forum

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Dr. Godwin Anywar, at the 2024 World Science Forum that took place in Budapest, Hungary from 20th-23rd November. College of Natural Sciences, Makerere University, Kampala Uganda, East Africa.

Godwin Anywar, cohort 6, Makerere University, attended the 2024 World Science Forum that took place on November 20 – 23, 2024 in Budapest, Hungary. At the forum, he participated in a side event: ‘Trust in Science’, a workshop for early career researchers organized by the Global Young Academy (GYA) and the InterAcademy Partnership (IAP). 

On November 26 – 28, 2024, he attended the twentieth annual meeting of the African Science Academies (AMASA 2024) and the General Assembly of the Network of African Academies of Sciences (NASAC), in Algiers, Algeria. He presented on ‘Promoting Science Diplomacy for Sustainable Development in Africa’ as one the co-leads of the Science Diplomacy in Africa working group of the Global Young Academy’. 

Godwin also participated in the Uganda Text Book Academic and Non-Fiction Authors Association (UTANA)- hybrid symposium on authorship capacity where he moderated a panel session on Artificial Intelligence (AI) and academic authorship. With the theme ‘Capacity building for academic and nonfiction authorship for Africa’s Transformation’ the symposium took place from November 14 -15, 2024 in Kampala, Uganda. 

Additionally, he attended and moderated a session on the regulation and registration of herbal medicinal products (HMP) in African countries. Organized by the Society for Medicinal Plants and Natural Products Research (GA) in collaboration with PharmaConnect Africa NPC and The Natural Products Research Network for Eastern and Central Africa (NAPRECA), the session was part of an eSeminar series ‘Regulation of Natural Products – a Global Challenge’.

Source: CARTA Newsletter Issue 83

Mark Wamai

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Research

In vitro antifungal activities of medicinal plants used for treatment of candidiasis in Pader district, Northern Uganda

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Ms. Betty Akwongo presents her work on “Evaluation of antifungal activity of khaya anthotheca used for the treatment of candidiasis in Pader District, Northern Uganda” at the Annual Forum for Graduate Research and Policy Dialogue on 26th April 2024, Yusuf Lule Central Teaching Facility Auditorium, Makerere University, Kampala Uganda, East Africa.

Betty Akwongo, Esezah K. Kakudidi, Anthony M. Nsubuga, Morgan Andama, Mary Namaganda, Patience Tugume, Savina Asiimwe, Godwin Anywar & Esther Katuura 

Abstract

Background

The emergence of multidrug resistant Candida species to available drugs has led to renewed interest in the use of herbal medicines globally. This study scientifically verified antifungal effectiveness of five commonly used plant species in Pader district, against selected pathogenic candida strains.

Methods

Powdered roots of Momordica foetida, Sansevieria dawei and Distimake dissectus; and stem barks of Khaya anthotheca and Mitragyna rubrostipulata were extracted sequentially using petroleum ether and methanol, respectively; and total water extraction at 24.4 °C (maceration), 60 °C (decoction) and boiling water at 87 °C (hot water infusion). Extracts and their combinations, positive controls (amphotericin B, and fluconazole) and negative control (80% dimethyl sulfoxide, verified to be tolerable concentration to the tested Candida species) were screened and verified for their antifungal activity against Candida albicans (ATCC: American Type Culture Collection reference strain 10231, ATCC 90028, 0770a and 0796), C. glabrata (VVc 004, ATCC 2950) and C. tropicalis (ATCC 750 and 0210) using agar well diffusion and broth micro-dilution, respectively.

Results

Aqueous extract (24.4 °C) of M. rubrostipulata (ZOI: 18.00 ± 1.00 to 38.33 ± 0.17; MIC: 3.13 ± 0.00 to 20.83 ± 4.17; MFC: 12.50 ± 0.00 to 200.00 ± 0.00), methanol extract of K. anthotheca (10.11 ± 0.31 to 15.11 ± 0.65; 1.04 ± 0.26 to 12.50 ± 0.00; 12.50 ± 0.00 to 100.00 ± 0.00), and combination of aqueous extract (60 °C) of D. dissectus + methanol extract of K. anthotheca (7.89 ± 0.26 to 19.67 ± 0.37; 0.78 ± 0.00 to 50.00 ± 0.00; 12.50 ± 0.00 to 200.00 ± 0.00) exhibited broad spectrum antifungal activities and were fungistatic against all tested Candida species, which comprised 8 clinical/control and susceptible/resistant strains. None of the conventional drugs used demonstrated broad spectrum antifungal activity across all tested Candida species/strains.

Conclusion

Methanol extract of K. anthotheca, aqueous extract (24.4 °C) of M. rubrostipulata, and combination of aqueous extract (60 °C) of D. dissectus + methanol extract of K. anthotheca could be effective in the treatment of candidiasis. They demonstrated potential broad spectrum antifungal activity against different species and strains of tested Candida than the fluconazole and amphotericin B drugs. Their fungistatic nature showed their ability to inhibit fungal growth. Hence, these extracts/extract combination can offer better treatment option for candidiasis if they are standardized and also their active curative compounds isolated and made into antifungal drugs.

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