On Tuesday May 26, 2020, Makerere University (Mak) Management converged to share findings from the study whose aim of was “to detail characteristics and treatment outcomes of the Coronavirus (COVID 19) pandemic patients in Uganda”. Coronavirus being a novel and rapidly changing pandemic, it was essential that early lessons are obtained and synthesised. These lessons directly feed into the clinical care guidelines and eventually contribute to the country’s interventions. With funding from the Government of Uganda through the Makerere University Research and Innovations Fund (Mak-RIF), this study was successfully executed.The multidisciplinary research team was coordinated through the Makerere University Lung Institute (MLI) http://mli.mak.ac.ug/. This study was led by Dr. Bruce Kirenga, Director MLI, and Prof. William Bazeyo, Acting Deputy Vice Chancellor (Finance and Administration)-Mak as Principal Investigators. Other investigators were from Entebbe Regional Referral Hospital, Johns Hopkins University, Baltimore, USA, Uganda Peoples Defence Forces, The AIDS Support Organisation (TASO), Mulago National Referral Hospital, the College of health Sciences and Ministry of Health, Uganda.
This study was conducted on the first group of COVID-19 patients (56) at Mulago National Referral hospital and Entebbe Regional Referral hospitals. Patient enrolment has continued but below we exultantly share preliminary findings.
· Age: the average age of the patients in Uganda was 33 years which is far lower than has is reported elsewhere. In Wuhan China, for example, the average age is 59 while in the New York USA it is as higher (63 years). Older the patient have higher risk of severe forms of disease and ultimately the poorer treatment outcomes.
· Patient Presentation: Among symptomatic COVID-19 patients, the most common symptoms were fever (21.4%), cough (19.6%), runny nose (16.1%), headache (12.5%), muscle aches (7.1%) and fatigue (7.1%). However, more than half of the patients did not have any of these symptoms at diagnosis. These patients were largely travellers returning from abroad or contacts of the confirmed/symptomatic patients above. Unlike our patients, 80% of hospitalised patients in the western world were symptomatic.
· Laboratory and imaging tests: Coronavirus has been reported to affect almost all body tissues. To understand the extent of damage, our research team performed a wide range of tests including complete blood count, kidney function tests, troponin, lactate dehydrogenase which identifies for signs of damage to a wide range of body tissues, and C reactive protein-CRP. We found that 10.6% of the patients had low white blood cells, 26.3% had low platelets, and 12.8% had evidence of liver damage, while the kidneys had no evidence of damage. 12.2% had evidence of systemic inflammation and 43% had evidence of nonspecific tissue damage. The electrical heart activity was also checked with the electrocardiograph (ECG). All patients had normal ECG with the exception of one who had a very slow heart (bradycardia). We checked lung damage with Chest X-rays (CXR) and computed Tomography scans (CT). Three patients had significant lung damage on CT and CXR; while one of them had low oxygen saturation.
· Comorbidity: About 25% of the initial patients (56) reported having other medical conditions in addition to COVID-19. Most of the conditions reported were the non-communicable diseases such as hypertension and diabetes which accounted for 11%. High blood pressure (higher than 140/90mmHg) was the most common comorbid disease recorded in up to 28% of the patients.
· Disease severity: At admission, only 2 patients met the classification of severe disease (patients with severe respiratory symptoms requiring oxygen therapy) while the rest had mild disease. Temperature and oxygen saturation were monitored three times a day. All the patients recovered without the need for admission to Intensive care unit (ICU) or ventilation. This is contrary to what has been observed elsewhere, where 5% of COVD-19 patients required ICU care.
· Treatment: To-date, there is no known cure for COVID-19. The current treatments are meant to alleviate symptoms while waiting for the body to mount an immune response to fight off the infection. The patients were able to recover on supportive care through managing the symptoms, treatment with antibiotics for those who had evidence of bacterial infection, hydroxychloroquine and vitamin C. In instances where the patients had comorbid conditions, proper management of these conditions was part of the treatment.
Conclusion: The initial group of COVID-19 patients diagnosed in the country presented with mild disease and exhibited a clinical course of disease that is quite different from what has been observed elsewhere. Imaging and laboratory tests are critical in management of this disease. Prompt identification of patients and initiation of treatment could help to prevent the development of severe forms of the disease. Frequent monitoring of the oxygen saturation is also critical for rapid patient identification and treatment. In light of the increasing number of cases in the country, these findings help in informing the national preparedness plan for COVID-19 (capacity building of health workers in clinical care for COVID-19, the required logistics, continuous research).
1. Expand testing for COVID-19 in view of the finding that almost half of those confirmed did not have the classical symptoms for COVID 19. Add rhinorrhoea to symptoms for case screening.
2. Efforts should be taken to make clinical, laboratory and imaging tests available at all COVID-19 treatment centres to support proper grading of disease severity. At a minimum, pulse oximetry should be routine in management of COVID patients.
3. Capacity to diagnose and treat non communicable comorbid conditions should be built across the country as part of COVID 19 response. Equipment for proper diagnosis of these diseases should be secured, installed and effectively used.
4. Strengthen monitoring, evaluation and learning as part COVID-19 care. This will allow continued learning of COVID-19 in general and the effectiveness of the different treatments of the disease.
5. Research should be supported including biomedical sciences research. This will allow growth of locally generated evidence to support the country’s COVID 19 response.
· The Government of the Republic of Uganda, Makerere University Research and Innovations Fund (Mak-RIF), Ministry of Health, Uganda, Uganda Virus Research Institute, Mulago National Referral Hospital, Entebbe Regional Referral Hospital.
· The study participants, all health workers engaged and Makerere University leadership.
Digital Health Payment Initiative and Research in Africa RFAs
The Digital Health Payment Initiative and Research in Africa (DHPI-R), a Bill and Melinda Gates Foundation-funded project that is implemented in Makerere University School of Public Health (MakSPH) and Université Cheikh Anta Diop de Dakar (UCAD) Senegal is thrilled to announce an OPEN CALL FOR REQUEST FOR APPLICATIONS. This will foster widespread, sustainable adoption and application of Digital Financial Service innovations within the health sector of low-and-middle-income countries (LMICs) in sub-Saharan Africa.
Focus Research Areas/ Research Themes
DHPI-R is seeking applications for studies that address the evidence gaps listed.
1) Campaign Effectiveness
2) Digital Financial Services’ effects on financial inclusion, safety, and security of payments
3) Health worker performance and retention
4) Payment experience and financial behavior
For any request made in this call, the budget goes as follows;
Large studies:12 months $200,000
Medium studies: 9 months $100,000
Small studies: 6 months $60,000
All Institutions within sub-Saharan Africa
Funding Restrictions and Terms
The award will be a fixed fee agreement, and the total amount of the award will be stated in the award letter. The funding is intended to support the collection, analysis, and dissemination of research. The allocation of program funds will directly correspond to the monetary figures presented in the final Budget and disbursement of funds will be initiated upon the timely receipt of invoices, financial reports, and expected deliverables.
How to Apply
Applications must be submitted in English or in French.
Applications must be submitted through our website: Submit applications here.
Application deadline: 16th SEPT 2022
Award decisions: All applicants will be notified of the outcome of their submission by 30th October 2022.
For more information and application details, see; Call for Request for Applications
Call For Applications: ACHIEVE Training Program
ACHIEVE provides trainees with dissemination and implementation (D&I) and data science research skills and knowledge through experiential learning, mentoring, and “hands-on” immersion in global health implementation and data science research and methodologies. ACHIEVE is a consortium of ten institutions: Washington University in St. Louis, Boston College, New York University, University of Illinois Chicago, University of Makeni, University of Kwazulu-Natal, University of Rwanda, University of Ghana, Makerere University, University of Nairobi.
- One-year appointment at a research site in Sub-Saharan Africa or other partner site in a low and middle income country (LMIC)
- Up to $10,000 in research project seed funding, a monthly living stipend, travel expenses covered
- Mentored research training in global health, dissemination & implementation, and data science
Interest in applying D&I and data science methodologies in a global health area, with special focus on projects related to: children, adolescents, and their caregiving families; parenting; HIV/AIDS; mental health; cancer; nutrition; and environmental health.
See flyer below for more details on eligibility
- Please email Laura Peer at email@example.com express interest
- Letter of Intent (LOI) due September 1, 2022
- Full Application (2ndPhase—by invitation only) due November 1, 2022
- For more information visit https://sites.wustl.edu/achieve/
CHS Annual Report 2021
I hereby present to you the Makerere University College of Health Sciences (MakCHS) annual report for 2021. This report provides an overview of activities at MakCHS under our mandates of teaching and learning, research, and service delivery during 2021.
The MakCHS continues to lead the national response to the COVID-19 pandemic through case management, research on advances in SARS-COV2 prevention and treatment intervention, as well as supporting faculty and students to adapt to the new learning environment of blended approaches to sustain teaching and learning activities during the COVID-19 pandemic period. I wish to congratulate MakCHS staff and students upon the resilience exhibited through the COVID-19 pandemic and emerging stronger, with various approaches to blended learning to complement the clinical/practical training approaches.
It is my pleasure to congratulate all staff who have received promotions, new research fund awards and publications during this period. You continue to raise the bar of the College of Health Sciences as we strive to lead in providing transformational education and research to improve service delivery and well-being of all the communities we serve. I extend my gratitude to all our stakeholders including but not limited to all MakCHS staff, students, alumni, collaborators, partners, funders, patients, and doctors for the exemplary multi-disciplinary teams that continue to deliver high quality education and health care programs.
Our major challenge remains to innovate, develop, produce, and sustain local solutions to emerging global health challenges including the large burden of emerging and re-emerging infections as well as the burden of non-communicable diseases.
I therefore urge all faculty and students to seek and grab all opportunities for each one to utilise their role in this space as we advance science initiatives to impact lives in Uganda, Africa and globally. On behalf of the leadership at MakCHS, I pledge our unwavering efforts to provide all relevant support to facilitate you to achieve your career dreams for 2022 at MakCHS.
Professor Damalie Nakanjako MBChB, MMED, PhD
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