The evolutionary origins of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) are unknown. Current evidence suggests that insectivorous bats are likely to be the original source, as several 2c CoVs have been described from various species in the family Vespertilionidae. Here, we describe a MERS-like CoV identified from a Pipistrellus cf. hesperidus bat sampled in Uganda (strain PREDICT/PDF-2180), further supporting the hypothesis that bats are the evolutionary source of MERS-CoV. Phylogenetic analysis showed that PREDICT/PDF-2180 is closely related to MERS-CoV across much of its genome, consistent with a common ancestry; however, the spike protein was highly divergent (46% amino acid identity), suggesting that the two viruses may have different receptor binding properties. Indeed, several amino acid substitutions were identified in key binding residues that were predicted to block PREDICT/PDF-2180 from attaching to the MERS-CoV DPP4 receptor. To experimentally test this hypothesis, an infectious MERS-CoV clone expressing the PREDICT/PDF-2180 spike protein was generated. Recombinant viruses derived from the clone were replication competent but unable to spread and establish new infections in Vero cells or primary human airway epithelial cells. Our findings suggest that PREDICT/PDF-2180 is unlikely to pose a zoonotic threat. Recombination in the S1 subunit of the spike gene was identified as the primary mechanism driving variation in the spike phenotype and was likely one of the critical steps in the evolution and emergence of MERS-CoV in humans.
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Source: Prof. Denis K. Byarugaba, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University
The Vice Chancellor, Prof. Barnabas Nawangwe on 20th April 2026 inaugurated the Second Makerere University Health User Committee (Mak-HUC). The Committee was established by the Vice Chancellor in 2022 as part of his strategic mandate to strengthen and oversee the University Hospital services delivery.
Chaired by Dr. Allen Kabagenyi from the College of Business and Management Sciences (CoBAMS), Mak-HUC has as its members; Prof. Josaphat K. Byamugisha-Director Makerere University Health Services (MakHS) and Dr. Daniel Ronald Ruhweza-Department of Law and Jurisprudence, School of Law.
Other members include; Dr. Arthur Kwizera-Department of Anaesthesia and Critical Care, College of Health Sciences (CHS) and Makerere University Academic Staff Association (MUASA) Representative, Dr. Lillian Tukahirwa-Makerere University Administrative Staff Association (MASA) Representative, Mr. Godfrey Othieno- National Union of Educational Institutions (NUEI) Representative, and as Secretariat, Ms. Kevin M. Nabiryo-Directorate of Human Resources.
Prof. Barnabas Nawangwe (C) interacts with members of the 2nd Mak-HUC.
The 2nd Mak-HUC has been appointed for a period of four years effective 1st January 2026 with a mandate to: Guide, monitor and oversee delivery of health services by MakHS; Represent the interests and concerns of staff and students that use MakHS; Advise on alignment with sustainable health financing and insurance models; Strengthen systems for fraud prevention, digital transformation and access to specialized treatment, among other responsibilities.
The 1st Mak-HUC was chaired by Dr. Allen Kabagenyi and had as members; Prof. Josaphat Byamugisha, Dr. Fred Mayambala, Dr. Zahara Nampewo, Mr. Othieno Godfrey, Mr. Apunyo Paul Okiria and Ms. Ikiriza Racheal. Milestones during the first era included; Outpatient Department visits growth from 4,802 (2022) to 7,388 (Nov 2025) for staff and 14,641 (2022) to 19,069 (Nov 2025) for students.
Others milestones included; Commissioning of a fully equipped Operating Theatre, Establishment of a modern Imaging Hub, Development of a fully functional Audiology Unit, Expansion of the Temporal Bone Laboratory, Launch of the Olink Proteomics Platform and Enhancement of the Dental Unit with 32 dental chairs and experienced personnel.
All applications must be submitted electronically via the Makerere University Electronic Human Resource Management System through the above link (ehrms). Applicants will be required to provide the necessary information on the ehrms and attach the following documents:
An application letter clearly stating the job applied for and duly signed by the applicant.
An up-to-date curriculum vitae. The curriculum must also state the names and addresses of at least three referees.
Copies of academic certificates and transcripts.
A minimum of three recommendation letters duly signed by the referees.
The application should be addressed to:
The Chief Human Resource Officer Makerere University P.O. Box 7062 Kampala