The evolutionary origins of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) are unknown. Current evidence suggests that insectivorous bats are likely to be the original source, as several 2c CoVs have been described from various species in the family Vespertilionidae. Here, we describe a MERS-like CoV identified from a Pipistrellus cf. hesperidus bat sampled in Uganda (strain PREDICT/PDF-2180), further supporting the hypothesis that bats are the evolutionary source of MERS-CoV. Phylogenetic analysis showed that PREDICT/PDF-2180 is closely related to MERS-CoV across much of its genome, consistent with a common ancestry; however, the spike protein was highly divergent (46% amino acid identity), suggesting that the two viruses may have different receptor binding properties. Indeed, several amino acid substitutions were identified in key binding residues that were predicted to block PREDICT/PDF-2180 from attaching to the MERS-CoV DPP4 receptor. To experimentally test this hypothesis, an infectious MERS-CoV clone expressing the PREDICT/PDF-2180 spike protein was generated. Recombinant viruses derived from the clone were replication competent but unable to spread and establish new infections in Vero cells or primary human airway epithelial cells. Our findings suggest that PREDICT/PDF-2180 is unlikely to pose a zoonotic threat. Recombination in the S1 subunit of the spike gene was identified as the primary mechanism driving variation in the spike phenotype and was likely one of the critical steps in the evolution and emergence of MERS-CoV in humans.
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Source: Prof. Denis K. Byarugaba, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University
The Office of Academic Registrar, Makerere University has released lists of Successful appeals and supplementary lists. Below is a list arising from appeals of Government Sponsored candidates who have been admitted:
Makerere University and DFCU Bank have today signed a three-year Memorandum of Understanding (MoU) to bolster innovation, student leadership, research and community impact initiatives.
The collaboration which will see the equipping of the Disability Support center for students living with disabilities through the MAK run and more leadership trainings for students will begin this July.
“The MoU will strengthen research collaborations across sectors like agriculture and health and it will also support the Mutebile Centre to assist private sector growth, which is crucial in lifting Africa out of poverty,” said Prof. Barnabas Nawangwe, the Vice Chancellor.
Prof. Barnabas Nawangwe (R) flanked by Mr. Charles Mudiwa (L) makes his remarks at the MoU signing ceremony.
Speaking during the event, Mr. Charles M. Mudiwa, the DFCU Bank Chief Executive Officer, welcomed the move, noting its alignment with the bank’s mission to transform lives and support national development through four pillars: funding, financial inclusion, enterprise development, and vocational education.
“This MoU crowns years of effort and shared intent between our institutions,” he stated. Mr. Mudiwa highlighted the bank’s commitment to skilling youth through internships, curriculum development, and support for innovation hubs and centres of excellence at the university. “We consume the graduates of Makerere. In our most recent graduate intake of 87, 60% were Makerere alumni. The bank allocates around 30 internship positions annually to equip young people with the skills necessary for future roles within the institution,” Mr. Mudiwa, noted.
Representing the student body, Guild President His Excellency, Sentamu Churchill James, commended the partnership as a timely intervention that will empower youth, support SMEs, and expand internship and leadership development opportunities.
Prof. Barnabas Nawangwe (2nd L) presents a framed portrait of the Main Building to Mr. Charles Mudiwa (C) as L-R: University Secretary-Mr. Yusuf Kiranda, 91st Guild President-H.E. Ssentamu Churchill James and Acting Deputy Vice Chancellor (Finance and Administration)-Prof. Winston Tumps Ireeta witness.
“Students are the heartbeat of the university. This collaboration will empower youth and strengthen their role in national development,” His Excellency Ssentamu, said.
About MAK RUN 2025
The Makerere Run 2025 (#MakRun2025), hosted by the Makerere University Endowment Fund (MAKEF) on 17th August 2025, returns for its fifth edition as Kampala’s premier charity marathon, uniting 8,000+ runners—students, alumni, corporate teams, and elite athletes—to tackle the city’s iconic hills under the theme “Run the Hills for the Future.” This landmark event combines competitive racing with transformative impact, channeling proceeds to strengthen Makerere University’s community programs while offering unmatched branding opportunities for partners through Kampala’s largest university-led sporting spectacle.
The Mak Run, scheduled this year for August 17th, is a flagship initiative that mobilizes students, staff, alumni, and partners to raise funds for projects such as the Disability Support Unit and the Student Centre.