Dr. Sarah Kiguli of Makerere University leads the Fogarty-funded program: Enhancing Research capacity for Sickle Cell Disease and related NCDs across the Lifespan in Uganda (ENRICH).
Until recently in Uganda, most children with sickle cell disease (SCD) never celebrated their fifth birthday—only 30% lived past this milestone. This low survival rate was mainly due to inadequate health care interventions for these children, plus lack of widespread newborn screening, explains Dr. Sarah Kiguli, a professor at Makerere University College of Health Sciences. Things are different today. Over the past decade, the East African nation has instituted a policy of screening newborns while strengthening strategies to manage their health. This means more children with SCD are growing into adolescence and adulthood.
Challenges still exist, says Kiguli. For example, the community and district facilities where many Ugandan children are born cannot provide comprehensive services, including newborn screening. Another issue: the risk of SCD complications related to kidneys, lungs, heart—almost all organs—grows higher as patients grow older, yet scientific research in Uganda hasn’t caught up with the reality of these longer lives. As a result, teens and adults with SCD don’t get “the care they deserve,” says Kiguli.
“It’s very painful for us pediatricians to see our patients encounter challenges and problems when they transition to adult care.”
Renewed research focus
Despite years devoted to children’s health, Kiguli believes it’s time to prioritize studies exploring appropriate SCD management in teens and adults. “We need solutions that address all the patients’ needs, including reproductive health, as they transition out of childhood.” She’s spearheaded a multidisciplinary research training program for researchers focused on the needs of people with SCD at all ages: Enhancing Research capacity for Sickle Cell Disease and related NCDs across the Lifespan in Uganda (ENRICH).
“Among our PhDs, we don’t have anyone from pediatrics—and that’s fine,” says Kiguli. Importantly, the researchers are trained as a group to amplify the benefits of multidisciplinary collaboration. “We’ve been working in silos—pediatricians alone, physicians alone, social scientists alone—that won’t help us address the comprehensive needs of these patients.”
Methodology has also been given sufficient consideration. “We provide both individual and team mentorship from the beginning,” said Kiguli. Monthly meetings help trainees develop personal development goals and career path plans in the hope they will continue in the field. The program also provides research training to health professionals, such as medical doctors, laboratory personnel, and nurses, who are not necessarily doing degree programs, “so those who manage patients routinely might also benefit,” said Kiguli.
South-to-South unity
For the project, Makerere University has partnered with Busitema University, located in eastern Uganda, where “prevalence of the sickle cell trait is as high as 20%,” says Kiguli. (Sickle cell trait refers to when a person has inherited one mutated allele of the sickle cell gene, not two.) This local prevalence contrasts with about 13% prevalence elsewhere in the country. Studying the disease in a high burden locale is highly relevant, because results may influence policy and treatment guidelines.
Kiguli has other reasons for collaborating with Busitema University, which is less than 15 years old. “We want to build capacity at this young institution since our colleagues there have less chance of doing research than we at Makerere do.” Working and supervising trainees together will give Busitema’s faculty much-needed experience, while providing opportunities for faculty at both universities to learn from each other. Kiguli also hopes the new collaboration will advance progress made as result of the universities’ past partnerships. “Capacity must be built in a sustainable way,” says Kiguli.
“It’s important to work collaboratively and not competitively—this is just as important for Makerere University as it is for Busitema University.”
ENRICH trainees talk about their projects
Dr. Jackline Akello
Photo courtesy of Jackline Akello
Dr. Jackline Akello, PhD candidate
Dr. Jackline Akello, PhD candidate
My project is “Sickle cell disease in pregnancy: Experiences in provision and access to care and adverse pregnancy outcomes at Mbale and Kawempe Referral Hospitals.” As an obstetrician and gynecologist, I work as a lecturer at Makerere University and provide clinical care at the two national referral hospitals. I have encountered significant challenges in managing pregnant women with sickle cell disease (SCD) due to a number of healthcare navigation challenges. Additionally, the diverse cultural beliefs associated with SCD in Uganda affect access to care and ultimately outcome and quality of life for the patient.
By October, I will have started the enrolment of 161 pregnant women with confirmed SCD for my project. These participants will be followed throughout their pregnancies to track maternal and fetal complications, including stillbirths and low birth weight. Their experiences with the healthcare system will also be explored. As a Safe Motherhood champion, I have been focusing on hypertensive disorders in pregnancy, including pre-eclampsia, but this October at the Safe Motherhood Conference I will discuss the effects of SCD during pregnancy with the Ministry of Health. One of the endpoints of my study is to improve care for pregnant women who have SCD to enhance their pregnancy experience and outcomes.
Dr. George Paasi
Photo courtesy of George Paasi
Dr. George Paasi, PhD candidate
Dr. George Paasi, PhD candidate
My project is “The Clinical Epidemiology, Spatiotemporal Patterns and Disease Modifiers of Severe Malaria among Children with Sickle Cell Disease in Eastern Uganda.” Uganda ranks fourth among countries with high burden of SCD and is in the top 10 with respect to malaria burden. Eastern Uganda has the highest burden of both diseases. My project addresses this dual burden of SCD and malaria in eastern Uganda—I want to decipher the SCD-malaria syndemic in this region.
I’m a medical doctor, I have a master’s in public health, and I just finished a fellowship in infectious disease, epidemiology, and biostatistics. I’ve worked at Mbale Clinical Research Institute for the last 10 years. Previously, I worked on an NIH-funded trial in Africa called Realizing Effectiveness Across Continents with Hydroxyurea (REACH) as a medical officer, and now I’m embarking on this PhD training. My hope is that the findings from my study will improve the identification of patients with SCD at risk of adverse outcomes when they get malaria. I also want to identify, through spatial temporal analysis, hotspot locations that require priority interventions. I also want to gain skills as an independent researcher in SCD and make a meaningful contribution to this field.
Dr. Anita Arinda
Photo courtesy of Anita Arinda
Dr. Anita Arinda, PhD candidate
Dr. Anita Arinda, PhD candidate
My project is “Prevalence, associated factors, course and impact of major depressive disorder in adolescents with SCD in Mulago National Referral Hospital.” We have limited data on mental health of adolescents with SCD, so that’s why my project mainly looks at depression in adolescents (ages 10 to 17).
In our setting, we are fortunate that children with SCD live past their fifth birthday thanks to improved health care, but this presents new challenges. During adolescence, patients enter a crucial stage where they’re trying to develop their identity, yet they’re also beginning to understand the implications of their condition—that having this serious health condition cuts their life short. I want to understand their experiences. How does depression in adolescents with SCD differ from depression in adolescents without SCD? We know that sickle cell disease causes inflammation, so does that contribute to their depression? How does depression affect clinical outcomes, if at all?
If we can understand the underlying mechanisms of depression in teens with SCD, then we might find new ways to manage their care (as opposed to conventional treatment with antidepressants). I’ll do my research at Mulago National Referral Hospital, which has a clinic dedicated to children and teens with sickle cell disease. The clinic provides many services, but unfortunately no specialized mental health services. One day I hope that changes, so that children with SCD and depression can get help early.
This week, world leaders, negotiators and researchers are gathered in Antalya, Türkiye, for COP31, the United Nations climate conference, seeking to turn years of climate commitments into action countries can finance and implement. Among them is Dr. John Bosco Isunju, a climate and health researcher at Makerere University School of Public Health, named among TIME’s 100 most influential climate leaders in 2024.
Dr. Isunju led the School’s technical support to the Ministry of Health for Uganda’s 2023 Climate Change Health Vulnerability and Adaptation Assessment (VAA) and the subsequent development of the Health National Adaptation Plan (H-NAP) 2025–2030. The assessment covered 716 health facilities across 43 districts, documenting vulnerabilities that helped shape the country’s priorities for protecting healthcare from climate hazards.
Flood damage at Kilembe Mines Hospital in Kasese District. Damaged wards can disrupt treatment and limit access to care. Photo: H-NAP Team.
That experience speaks directly to the task before the 9–20 November summit. With “Dynamic and Resilient Health Systems” among the COP31 Presidency’s Action Agenda priorities, the conference is seeking practical solutions and financing to keep services functioning through climate shocks. Adaptation, the practical changes needed to cope with a changing climate, must ultimately reach the facilities where people seek care.
Protecting facilities from floods and drought also safeguards the public investment behind them, giving Uganda’s adaptation effort an economic significance alongside its importance to patients. In a 27 October 2026 statement ahead of COP31, UN Climate Change Executive Secretary Simon Stiell placed climate action within that wider calculation of public benefit.
“More governments are taking climate action right across their economies, to bank the vast benefits of clean energy and climate resilience,” he said. “Almost every major economy, and many medium-sized and smaller economies, now see climate action as a central driver of economic growth, jobs, and affordable and secure energy.”
UN climate chief Simon Stiell delivers opening remarks at COP31 in Antalya, Türkiye. Photo: UN Climate Change/Kiara Worth.
On 21 October, nearly three weeks before the Antalya talks, the H-NAP was before Ugandan parliamentarians in Kampala. Convened by the Ministry of Health and Parliamentary Forum on Climate Change Uganda, with support from Regenerate Africa and the Clinton Health Access Initiative, the engagement examined the plan and Parliament’s role in securing funding, scrutinising implementation and ensuring accountability.
Presenting the VAA, Dr. Isunju explained that the team examined the hazards facing each area, the extent of exposure and the weaknesses that made services vulnerable. They also considered the communities the facilities served. A flood could turn an already difficult journey to treatment into one that patients and staff could no longer make, as seen in many parts of Uganda, including Kasese.
“Either health workers will not work, or communities will not be able to access care, or outreaches will not be possible because roads are cut off,” he told legislators.
MPs at the orientation on implementing Uganda’s Health National Adaptation Plan, led by Makerere University School of Public Health, the Ministry of Health and partners in Kampala, 21 October 2026.
Uganda’s H-NAP grew out of commitments made at COP26 in Glasgow in 2021 to assess health vulnerabilities and develop an adaptation response. The Ministry of Health commissioned the School to undertake the VAA in 2023, with Rockefeller Foundation funding supporting both the assessment and the plan’s development. Developed through stakeholder consultation, with WHO technical support and contributions from other partners, the plan was launched on 22 August 2024.
What the assessment found
The VAA found that drought and floods were disrupting the conditions needed to deliver care. Nearly half of the assessed facilities reported drought exposure, while about two in five reported floods. Among the 284 facilities reporting flood exposure, 141 (about half) said health professionals had been unable to arrive at or leave their workplaces, and 198 (about seven in ten) reported shortages of safe water. Because districts were selected for their history of hazards, these findings describe the assessed facilities and cannot be treated as national estimates.
Findings from Uganda’s 2023 health vulnerability assessment helped shape its Health National Adaptation Plan 2025–2030.
The H-NAP responds across ten components of the health system, including leadership, workforce training, risk monitoring and sustainable financing. Its proposed actions include revising infrastructure standards and using weather and disease information to warn of health risks earlier. Protecting care requires investment in buildings alongside the people and systems that make them function.
“A significant proportion of healthcare facilities lack water management and safety plans to address contamination risks,” the H-NAP states. “They lack water safety plans and contingency plans for monitoring and reducing contaminants as well as on-site water purification equipment.” Such gaps can leave facilities unable to maintain hygiene, clean equipment and provide treatment safely when water supplies fail or become contaminated.
The H-NAP already includes a budget, giving implementation a basis for resource mobilisation. The UN climate secretariat’s 2026 report on national adaptation plans across sectors identifies the difficulty of turning priorities into fundable projects. It recommends costing specific interventions and securing delivery partners, steps that can help advance Uganda’s health adaptation priorities.
At household level, climate pressures on livelihoods can leave families less able to get care or keep children in school, as community consultations showed.
“Their problems are interconnected. If climate, for example, affects their livelihoods, it directly impacts their health, because that means when they fall sick they can’t get care, and they can’t take their children to school, so things are all interconnected,” Dr. Isunju said.
Dr. John Bosco Isunju briefs MPs on climate risks to Uganda’s health services in Kampala, 21 October 2026.
The Ministry’s Focal Point for Climate Change and Health, Dr. Didacus Namanya, told MPs that resilience, the ability to withstand disruption and keep providing care, must inform how services are built and managed.
“So, our vision in the H-NAP is to have a responsive, adaptive, and resilient health system. Adaptive, we are talking about adaptation. These impacts will not stop; they will continue coming, but we must develop our adaptive capacity. The way we build our health facilities, the way we tackle the disease burden, we must be highly adaptive,” he said.
Dr. Namanya called for district-specific assessments, noting the different conditions in Nakasongola and Bududa, and described an ongoing review of infrastructure design standards. Dr. Isunju reported that guidelines for coordinating climate and health action across institutions were undergoing approval.
A partnership announced in October 2025 by the Rockefeller Foundation and the International Development Research Centre is helping the School and the Clinton Health Access Initiative, working with the Ministry of Health, build an investment case for H-NAP implementation. A separate Ministry of Health and Global Green Growth Institute initiative, begun in June 2026, is advancing climate-resilient water, sanitation and hygiene standards, investment plans for health facilities and the government’s capacity to deliver improvements.
Rt. Hon. Lukia Isanga Nakadama signs a display copy of Uganda’s Health National Adaptation Plan at its launch in Kampala, 22 August 2024.
Questions for Antalya
Legislators sought evidence of what implementation had delivered. Terego East MP Hon. Wilfred Babanga Erima asked how much of the plan had been implemented, how many facilities had been audited and refitted for climate resilience, and how funding was divided between domestic and donor sources. Hon. Shafiga Wanyenya, Vice Chairperson of Parliament’s Committee on Climate Change, proposed joint follow-up with the health committee and regular progress reviews.
“Our role is to ask the difficult questions and also identify implementation gaps, to advocate for the vulnerable communities and ensure that the national commitments translate into tangible improvements in the lives of our people,” Hon. Wanyenya said.
Hon. Shafiga Wanyenya, Vice Chairperson of Parliament’s Climate Change Committee, calls for oversight of Uganda’s health adaptation plan in Kampala, 21 October 2026.
Those questions belong in Antalya too. The Yearbook of Global Climate Action 2026 identifies gaps in global data for assessing whether health systems are becoming more resilient, underlining the importance of tracking what adaptation efforts deliver for health.
The COP31 health programme links implementation of the Belém Health Action Plan with a financing framework intended to help turn health priorities into investable projects. Launched on 9 November, the Antalya Initiative for Health Resilience provides a platform for countries to share practical experience. The COP28 adaptation framework sets targets for climate-resilient health services by 2030 and progressively beyond, alongside national adaptation planning by 2030 and multi-hazard early-warning systems by 2027.
The H-NAP gives Uganda a practical agenda for that next stage. It calls for climate and health priorities to enter government budgets and for proposals capable of attracting finance. It also identifies academic partnerships as a route to research and capacity-building funds. Annual reviews would then assess progress and guide subsequent work.
As negotiations continue in Antalya, the next test is whether decisions there, and action at home, help keep care available, on the road to a health facility, and at the water point on which safe treatment depends.
Makerere University’s Professor Peter Waiswa has been appointed to the World Health Organization (WHO) Technical Working Group of Experts tasked with developing the Essential Child Health Services (ECHS) framework.
The appointment, communicated in an official letter dated October 21, 2026, and signed by Dr. Pascale Allotey, Director of WHO’s Department of Sexual, Reproductive, Maternal, Child, Adolescent and Ageing Health, runs until December 31, 2027.
The technical working group will support WHO in defining a core package of essential health services for newborns, older children and adolescents, alongside practical approaches for delivering these services effectively and equitably to improve their health and well-being.
As a member of the working group, Prof. Waiswa will contribute scientific and technical expertise to the development of the framework. His responsibilities will include participating in technical consultations, reviewing draft documents, providing written feedback and contributing to consensus-building on key technical issues.
The group is expected to hold approximately five online meetings between November 2026 and mid-2027. Members will serve in their individual capacities as independent experts rather than as representatives of their respective governments or institutions.
The appointment builds on Prof. Waiswa’s longstanding service and contributions to WHO. He previously served for seven years on WHO’s Strategic and Technical Advisory Group of Experts (STAGE) on Maternal, Newborn, Child and Adolescent Health and Nutrition, with his tenure concluding in June 2026.
Makerere University proudly celebrates the recognition of Mr. Mordecai Tayebwa, Senior Grants Manager, Makerere University Lung Institute and Ms. Bonny Tusiime, Grants and Contracts Officer, Makerere University College of Health of Sciences (MakCHS) as recipients of the prestigious Future of the Field Award of Society of Research Administrators International (SRAI), an international recognition that Honors emerging leaders making outstanding contributions to the advancement of research administration. This year’s ‘Future of the Field’ honorees were formally recognized at SRAI’s Annual Meeting held in Honolulu, Hawaii, USA in October, 2026.
The Future of the Field Award recognizes professionals who demonstrate exceptional leadership, innovation, and commitment to strengthening research management and administration. The award celebrates individuals whose work is shaping the future of the profession by improving research support systems, fostering collaboration, and advancing excellence in research administration.
At Makerere University, Mr. Tayebwa and Ms. Tusiime have played key roles in strengthening grants and contracts management, supporting researchers throughout the grant lifecycle, promoting compliance with sponsor requirements, and contributing to the development of sustainable research management systems. Their efforts have enhanced institutional capacity to attract, manage, and administer competitive research funding while ensuring accountability and excellence. Commenting on the recognition, the award recipients expressed their gratitude for the opportunity to contribute to the growth of research administration. “This recognition reflects not only our individual efforts but also the collaborative environment at MakCHS and Makerere University. It inspires us to continue strengthening research administration and supporting researchers in generating impactful scientific discoveries that improve lives.” They said.
The achievement highlights the growing international recognition of research administration professionals in Africa and underscores Makerere University and MakCHS’s general commitment to building strong research support systems that enable world-class research. This also reflects the institution’s investment in professional development and its dedication to advancing research excellence through effective grants management.
Commenting on the award, Dara C. Little, President, (SRAI) said “In a field as dynamic and rapidly evolving as research administration, the need for visionary,adaptable leaders have never been greater,” . “SRAI’s Future of the Field recipients represent the next generation of changemakers – those who will not only navigate complexity but shape the future of our profession. To embrace change, is to lead your innovation, resilience, and leadership are exactly what this moment demands. Rise to the opportunity and you will do great things!”
Makerere University congratulates Mr. Mordecai Tayebwa and Ms. Bonny Tusiime on this significant achievement and wishes them continued success as they contribute to shaping the future of research administration both regionally and globally