Natural Sciences
Mak Researchers Set Out to Address the Challenge of African swine fever in Uganda
The Project is supported by the Government of Uganda through the Makerere University Research and Innovations Fund (Mak-RIF).
Overview
African swine fever (ASF) is a highly contagious viral haemorrhagic disease of domestic pigs; and has recently spread to new areas including Eastern Europe and in Asia as far as Papua New Guinea. This disease has neither vaccine nor treatment and is currently a big challenge to many smallholder pig farmers in Uganda. In Uganda, ASFV genotype IX has been reported to cause outbreaks on a regular basis and is an impediment to development of the swine industry. The disease was previously reported with a mortality of 100%. However different forms of the disease have recently been observed in domestic pigs. Indeed, some studies have shown that pigs that survive ASF become resistant to the same viral isolates although they do not produce classical neutralizing antibody. These observations could have the key for vaccine development strategies.
The research project
Through a project titled “African swine fever virus (ASFV) severity and viral genomic structural features: opportunities for development of a vaccine in Uganda”, a team of researchers led by Prof. Charles Masembe from the Department of Zoology, Entomology, and Fisheries Sciences at Makerere University registered the need to correlate clinical studies of ASF virus with full genome sequences and virus structural data to identify potential candidate genes for vaccine development. The team set out to isolate and characterise highly virulent and low virulent ASF viruses circulating in the swine population in Uganda using next-generation and Electron Microscopy to inform the development of ASFV vaccines and other therapeutic strategies. The team also set out to sequence the whole genome of low and high-virulence African swine fever viruses circulating in the domestic pig population in Uganda; compare the whole genome sequences of low and high-virulence ASF viruses in Uganda, and to find genomic variations and their effects on the virulence and viral evolution. Whole blood and organ tissue samples together with clinical-epidemiological information, were collected from acute and chronic cases of pigs in reported ASF outbreaks in the districts of greater Masaka, Greater Gulu, Mukono, Wakiso, Kakumiro, and additionally in other districts were outbreaks were reported during the study period. The project was supported by the Government of Uganda through the Makerere Research and Innovations Fund (MakRIF). Other members on the project are; Assoc. Prof. Vincent Muwanika (Co-PI), Dr. Rose Ademun (Scientist), Dr. Mathias Afayoa (Scientist), Dr. Tony Aliro (Field Scientist), Mr. Peter Ogweng (Field Scientist), Mr. Mayega Johnson Francis (Lab Technologist), Okwasiimire Rodney (Lab Technologist), and Mr. Bright Twesigye (Administrator).
Dissemination of the research findings
On 15th May 2024, the project team held a workshop at Doves Nest Hotel in Gulu District to disseminate the research findings, and to fact check by mapping pig farms, abattoirs, slaughter slabs, and pork restaurants in both Gulu District and Gulu City for on-going and future research.
The workshop was officially opened by the Assistant Chief Administrative Officer (CAO) of Gulu District, Mr. Okidi Cosmas James on behalf of the CAO. In his remarks, Mr. Okidi appreciated the project team, noting that the workshop was timely since piggery as a poverty alleviation programme had been embraced by most farmers as a replacement for cattle. Sharing his experience, he expressed concern over the increasing threat of ASF, a factor he said was undermining the growth of the swine industry in Uganda.
During the meeting, the Project PI, Prof. Charles Masembe presented the status of ASF research in Uganda and globally, highlighting the complexity of ASF, dangers of ASF, ASF diagnostic advances, importance of keeping pigs and scientific efforts to control ASF, including the advances in the development of the ASFV vaccine.
Other presentations focused on ASF control and prevention mechanisms, potential role of production systems in ASF transmission, community involvement in disease control, spatio-temporal spread of ASF at the wildlife-livestock interface, the role of carrier pigs in ASFV transmission and maintenance, biosecurity implementation and challenges. All these presentations evoked discussion points from the participants. Participants expressed the need to understand how ASF is transmitted, and the extent to which farmers can trust veterinarians since they are considered to spread the disease. They highlighted the need to institute quarantine during ASF outbreaks and called for sensitization on the acceptable methods for disposing off infected pork. Another concern arising from the meeting was the need to understand if ASF is zoonotic and if not, why ASFV infected pork should not be eaten. Participants also sought guidance on why farmers should continue to keep survivor pigs if they spread ASFV, and why the government has not constructed slaughter slabs in all villages to control the spread of ASFV.
Recommendations by participants;
- Strengthening community awareness through different production departments in the district and city by organizing workshops as closer to the farmers as possible for example at every parish or ward.
- Makerere University ASF research team should collaborate with Gulu University, Faculty of Agriculture and Environmental Studies so that ASFV diagnosis and research is jointly done at the University which is nearer to the farmers for quick response to ASF outbreaks.
- City, District, and sub-county leaders should formulate a by-law to enforce the implementation of ASF control and prevention methods.
During plenary, participants were tasked with mapping pig farms/farmers, abattoir/slaughter slabs and pork restaurants in their respective sub-counties in Gulu District and Gulu City, in addition to generating a comprehensive farm/farmer list in the two areas. Mapping was successfully done and presented for purposes of clarity by each team representing a particular sub-county. The participants were then given a template to populate on the farm/farmer list since they could not recall all farms/farmers name and their mobile phone contacts.
Remarks by Gulu District RDC
In his closing remarks, the RDC of Gulu District, Mr. Oryem Auric thanked the research team for choosing the district for the workshop, noting that the feedback from the participants indicated that the workshop was very beneficial to them. He pledged to dedicate some of the free airtime offered to his office on Radio Mega, a popular FM Radio Station in Gulu City affiliated to Radio Uganda, towards the popularization of the project activities. He reiterated that the objectives of the project were in line with the current Government of Uganda programme on wealth creation through the Parish Development Model and the 4 acre model of which piggery is one of the means recommended for poverty alleviation by the President of Uganda. He called on the farmers to embrace and utilize the knowledge acquired to improve their farms and increase their household incomes.
A team of researchers from Makerere University has presented findings of a study on the persistent poor performance in Biology in national examinations to senior officials at the Ministry of Education and Sports.
The findings were shared during a dissemination meeting attended by the Ministry’s top management, led by Permanent Secretary Kedrace Turyagenda.
The study, commissioned by the Ministry in 2023, was conducted by researchers from the College of Natural Sciences (CoNAS) and the College of Education and External Studies (CEES). It was spearheaded by Prof. Fredrick Muyodi as Principal Investigator, alongside Assoc. Prof. Josephine Esaete (Co-Principal Investigator) and Prof. Arthur Tugume among others.
Titled “Examining the Factors Accounting for Poor Academic Performance in Biology in Uganda’s National Examinations,” the study covered all regions of the country, engaging more than 5,200 respondents across 100 districts through surveys, interviews, and observations.
Key findings
The research identified limited field-based learning and poor digital access as the most critical and consistent challenges affecting both Ordinary and Advanced Level students across all regions.
At Advanced Level, the lack of project-based learning was also cited as a significant constraint. Learners reported limited engagement with Biology beyond the classroom, a factor that weakens conceptual understanding and application in examinations.
The study further highlighted the role of community attitudes and perceptions in shaping student performance in the subject.
Recommendations
The researchers recommended increased investment in field-based learning, including field trips and project work, as well as expansion of digital infrastructure to improve access to learning resources.
Other proposed measures include strengthening school laboratory facilities, enhancing teacher capacity through continuous professional development, promoting student engagement through academic clubs and mentorship programmes, and fostering stronger family and community support for science education.
Next steps
The research team is seeking funding to pilot targeted interventions, particularly in regions most affected by the challenges identified, and to develop a monitoring and evaluation framework to guide implementation.
The findings are expected to inform policy and interventions aimed at improving Biology performance and strengthening science education in Uganda.
By Dr. Alice Nabatanzi
At the Department of Plant Sciences, Microbiology, and Biotechnology (PMB) in the College of Natural Sciences, we are moving beyond the classroom to bring science to life. We are proud to showcase our innovative work with the Biotechnology Class of 2026. Our Product Development Centre has transitioned from theoretical research to practical, market-ready innovations. By applying advanced scientific principles, our students are developing tangible solutions that address everyday needs in nutrition, health, and industry.
Below are the latest products developed by our talented innovators:
- Nutrition & Food Technology: Vitamin A-rich bread, banana vinegar, food syrups, and fortified bio-snacks.
- Clinical Hygiene: Perfumes, Deodorants, Antibacterial gels, herbal toothpaste, shaving cream, and herbal mouthwash.
- Natural Wellness: Natural formulas for gut health, pain relief, cough lozenges, and nasal decongestants.
- Advanced Cosmeceuticals: Turmeric SunGuard patches, skin serums, toners, and anti-dandruff shampoo.
- Home & Industrial Solutions: Shoe deodorizing sprays, surface cleaners, and scented hygiene products.
- Agri-Tech: Natural bioindicator kits designed to monitor and improve soil health.
Through these initiatives, PMB continues to lead the way in re-engineering science for the benefit of our community and the world.
Meet the Biotechnology Class of 2026. While everyone else is still stuck in textbooks writing about “how things might work,” we’re in the lab making sure they actually do. We’ve officially moved past the days of just talking about science and stepped into the era of real-world industry. From our Product Development Centre to the global market, we are setting a new standard for Biotechnology at CoNAS. We aren’t just graduating with degrees; we’re graduating with the future in our hands.
What’s Next: We’re Just Getting Started
This is only the beginning. We’re already working on the next wave of products, from eco-friendly bio-packaging and better probiotics to smart-crop tech that will change how we eat, heal, and live. We aren’t just waiting for the future to happen we’re in the lab building it right now.
Dr. Alice Nabatanzi is a Senior Lecturer of Phytomedicine and Nutraceuticals at the College of Natural Sciences (CoNAS), Makerere University
Natural Sciences
Transforming Food Waste into Clean Energy: Makerere University Researchers Equip Mbarara City Residents with Biogas Production Skills
*****Led by Dr. Patience Tugume from the Department of Plant Sciences, Microbiology and Biotechnology at Makerere University, a project titled “Bio-innovation of biogas, biofertilizer, and biopesticide through the utilization of bio-waste” is promoting the transformation of household food waste into biogas and other valuable bio-products. The project team disseminated the research findings to stakeholders in Mbarara City on 15th April 2026.
About the Project
A one-year bio-innovation initiative focused on converting household food waste into biogas, biofertilizer, and biopesticides has yielded promising results in improving access to clean energy and promoting sustainable agricultural practices in peri-urban communities of Mbarara City.
The project, implemented by Makerere University in collaboration with Frevasema Ltd in Mbarara, was supported by UNESCO and the International Development Research Centre (IDRC) – Canada through the Organization for Women in Science for the Developing World (OWSD). Launched in January 2024, it is led by Dr. Patience Tugume from the Department of Plant Sciences, Microbiology and Biotechnology at Makerere University.
The initiative has been implemented across five divisions of Mbarara City – Kakoba, Kamukuzi, Nyamitanga, Biharwe, and Nyakayojo – with additional field trials conducted in Masha Sub-county, Isingiro District.
Objectives of the project
The central aim of the project was to demonstrate how biodegradable household waste can be transformed into useful products, particularly biogas for cooking, as well as organic biofertilizers and biopesticides for improved crop production.
Key objectives of the project included: establishing a spin-off centre of bioreactors at the business partner institution (Frevasema Ltd) to demonstrate sustainable production of biogas, biopesticides and bio-fertilizers; training and equipping women and youth with hands-on skills in biogas production and usage; evaluation of yields from different bio wastes; and creation of linkages between academia, the private partner and rural communities in up-scaling production of biogas, biopesticides and bio-fertilizer from household/urban biodegradable wastes.
Key Activities and Dissemination of Project Findings
The project team conducted a survey to assess community perceptions and the factors influencing the adoption of biogas as an alternative cooking energy source in peri-urban areas of Mbarara City. In addition, biodigester tanks were constructed at FREVASEMA Ltd to support training and knowledge transfer activities.
Field experiments were undertaken in Masha Sub-county, Isingiro District to evaluate the effectiveness of an integrated biofertilizer–biopesticide. Further experiments to assess biogas yield from different types of food waste were conducted at Makerere University.
The team also developed an integrated biofertilizer–biopesticide by enhancing bioslurry, a by-product of biogas production, with plant extracts known for their pesticidal properties. The effectiveness of this product was tested on the growth performance of green pepper, cabbage, and eggplant.
In line with one of the project objectives, the team also conducted hands-on training in biogas production from food waste for 35 students and 6 staff members of MAMITA Technical and Business Institute.
Dissemination workshop
On 15th April 2026, the project team led by Dr. Tugume held a dissemination workshop to share findings with stakeholders and discuss strategies for scaling up the outcomes.
Findings from the research highlight the strong potential of biogas in contributing to sustainable energy solutions, improving livelihoods, and enhancing environmental conservation through proper food waste management.
Key research findings
- The application of integrated biofertilizer–biopesticide presents a viable alternative to scarce, expensive, and environmentally harmful inorganic fertilizers for enhancing vegetable productivity.
- The study revealed that approximately 90.7% of respondents depend on charcoal and firewood as their primary cooking fuel.
- While 92.1% of respondents were aware that biogas is produced from animal and plant materials, only 7.9% recognized that food waste can also serve as a feedstock, indicating limited awareness of its full potential.
- Banana and potato peels, as well as posho and potatoes leftovers, and green vegetable trimmings, were identified as the most commonly generated food wastes.
- A majority of respondents strongly agreed that biogas is a cleaner and more sustainable energy alternative compared to firewood.
- Key barriers to biogas adoption included inadequate technical knowledge, safety concerns regarding biogas systems, and the high costs of constructing and maintaining biodigesters.
- The extremely low adoption rate of biogas technology (0.3%) indicates significant underutilization despite its potential to mitigate fuel shortages.
- There is a prevailing perception that biogas is suitable for cooking and can effectively replace biomass fuels, given the availability of sufficient feedstock from household food waste, human waste, and animal manure.
- Potato and posho residues were identified as the most suitable primary feedstocks for biogas production due to their high nitrogen content, volatile solids, and total organic carbon (TOC).
- Effective collection and proper segregation of food waste are essential for ensuring a consistent and uncontaminated supply of feedstock for biogas production systems.
- Further research is recommended on integrated biogas systems that combine anaerobic digestion with other renewable energy technologies, such as solar energy or bioelectrochemical systems, to improve overall energy recovery efficiency.
- Vegetables treated with the integrated biofertilizer–biopesticide consistently exhibited superior performance across all growth parameters compared to those treated with inorganic fertilizers (including 5% cypermethrin pesticide) and untreated controls.
Stakeholder engagement and appreciation of the initiative
During the dissemination workshop, Dr. Patience Tugume, the Principal Investigator, expressed gratitude to UNESCO and the International Development Research Centre (IDRC)-Canada, through the Organization for Women in Science for the Developing World (OWSD), for funding the project. She appreciated the research team composed of Dr. Asiimwe Savina, Prof. Maud Kamatensi-Mugisha, Prof. Bazirake Byarugaba, Ms. Catherine Kiconco and Mr. Muhumuza Robert for their contribution. She equally appreciated all participants for contributing valuable information to the study.
Stakeholders commended the project for its relevance and community impact.
Prof. Bunny Lejju Julius from Mbarara University of Science and Technology, appreciated the project team for developing an innovation that directly addresses community needs and aligns with the principles of the competency-based curriculum, particularly the translation of academic knowledge into practical application. He advised that sustainability of the initiative could be strengthened through a multiplier approach, where the trained learners cascade the knowledge to other community members. He further recommended the identification of institutional staff who can undergo training at the spin-off centre and subsequently serve as trainers within their respective communities.
The portable biodigester system was recognized as a simple, affordable, and practical technology with the potential to provide a cost-effective alternative to charcoal and electricity. Participants noted that while resistance to change remains a challenge, continuous awareness creation is essential to promote adoption and facilitate behavioral change.
Mbarara District Forest Officer, Ms. Ainembazi Joses, highlighted the importance of the biogas production project in environmental conservation. She noted that the initiative contributes to reducing deforestation by offering an alternative to firewood and charcoal, thereby supporting sustainable natural resource management.
The Local Council Chairperson of Mailo-Biharwe Division, Mr. Didas Katabazi, appreciated the project team for the innovative work and its potential benefits to the community. He pledged to use his office to advocate for increased government support to scale up the project.
The Resident City Commissioner of Mbarara City expressed concern over the rising levels of deforestation in the district and commended the Principal Investigator for spearheading the innovation. He reaffirmed the government’s commitment to supporting science and innovation. He emphasized the importance of integrating environmental protection with agricultural productivity, explaining that food security remains a national priority. He further noted that the project demonstrates the concept of waste valorization, where organic waste is transformed into valuable products such as biofertilizers and biopesticides, thereby enhancing agricultural productivity. He pledged to engage the Office of the President to support wider dissemination of the project outcomes. Additionally, he encouraged the trained students to act as ambassadors of the project by sensitizing communities on the benefits of biogas as an alternative source of cooking energy.
Way forward
- The government should invest in constructing bio digesters for households at subsidized prices or offer them financial assistance to cater for bio digester construction.
- Awareness campaigns about the production and use of biogas and associated benefits should be intensified in communities to dispel the negative perceptions.
- Provision of technical training in operating and maintenance of biogas installations should be conducted.
- Sorting of wastes at household level should be emphasised to separate biodegradable from non biodegradable ones.
- The integrated bio-fertilizer-bio-pesticide is an effective, sustainable strategy to increase vegetable productivity while improving soil health in nutrient-limited soils.
- The project recommends adoption of bio-fertilizers (e.g., bio-slurry) which are affordable and can be made from kitchen and market waste to reduce dependence on expensive chemical fertilizers to improve crop growth while controlling pests safely in addition to being safe for humans and the environment.
Donation of portable biodigester systems
As part of the commitment to translate research into tangible benefits, the project awarded two women and MAMITA Technical and Business Institute with portable biodigester systems for installation and use in their households and institution respectively. These systems will serve as demonstration units within the community showcasing the practicality, affordability, and impact of clean energy solutions at the household level.
Report compiled by Dr Patience Tugume, Principal Investigator & Senior Academic Staff in the Department of Plant Sciences, Microbiology & Biotechnology at Makerere University
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