Etheldreda Nakimuli-Mpungu is a rising researcher and clinician doing innovative work in mental health and HIV in sub-Saharan Africa. She is a Senior Lecturer and psychiatric epidemiologist in the Department of Psychiatry at Makerere University College of Health Sciences (MakCHS) and head of the consultation–liaison psychiatric service at Mulago National Referral Hospital, Kampala, Uganda. Almost a decade ago, she recalls that “around that time, there were researchers who had resolved that Africans cannot comprehend psychotherapy; therefore, they gave persons living with HIV antidepressants as first-line treatment for mild-to-moderate depression in their research studies. In fact, there was an NIH funded grant in my department at the time that was evaluating the use of antidepressants for depression among people living with HIV. I said to myself, but this is not right because antidepressants are not the first-line treatment.” She “strongly believed that what we should be doing was to develop culturally appropriate psychotherapy for depression” in this population.
Nakimuli-Mpungu’s PhD had shown depression was fairly common among patients attending rural HIV clinics in Uganda and it affected their adherence to antiretroviral treatment. She successfully submitted a research proposal to Grand Challenges Canada and, together with her colleagues, teamed up with Edward Mills in Canada to develop and test in a pilot trial a culturally sensitive group support psychotherapy (GSP) for people with mild-to-moderate major depression and HIV. Nakimuli-Mpungu and colleagues went on to complete a cluster randomised trial to evaluate the model on a large scale, with trained lay health workers delivering the GSP. They showed that the effect of GSP on depression was sustained at 2 years, and treating depression resulted in improved adherence to antiretroviral medication. Nakimuli-Mpungu and colleagues are now seeking to replicate their work on GSP outside of Uganda. “That is the next step…If we have that evidence as well, then we’re at the stage of scaling up.” They are also adapting their model for young people aged 10–18 years and are creating an online platform to deliver psychotherapy because, she notes, the COVID-19 pandemic has created a need for digital health.
Mills, Professor at the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada, comments: “Ethel is among the most important clinical researchers in Africa as she has the unique ability to ask important questions, get the clinical trials funded and conducted reliably, and personally analyses the data. Very few researchers anywhere can do all of this themselves.”
Her parents encouraged Nakimuli-Mpungu to pursue medicine. “Our parents really wanted us to get educated and become worthwhile citizens”, she says. “My earliest memory was that my mum used to say that girls become doctors”. Fortunately, Nakimuli-Mpungu found sciences interesting and excelled in them. She studied medicine at MakCHS, graduating in 1999. Her path to psychiatry and research came during a job as a medical officer at Butabika National Referral Mental Hospital in Kampala. She initially thought she would be working in the hospital’s general ward. But when she arrived, she was assigned to the female psychiatric ward and told to start seeing patients. “Almost immediately, I noticed there were really physically sick people on the psychiatric ward, and I had never seen this in my training. Very sick people: wasted, coughing, chronic diarrhoea. It didn’t take long to realise that these were patients with HIV.” But she could find little information on HIV and mental health in her psychiatric textbooks and searched online for research on HIV and mental disorders. “When I read those papers, immediately I said, I think this is the research I should also be doing, here in these patients who I’m seeing on a daily basis.” Butabika Hospital gave her a scholarship and she enrolled in the masters in psychiatry programme at MakCHS in 2003, graduating in 2006. Her research was a comparative study of primary mania versus secondary mania of HIV/AIDS. “It was, to my knowledge, the first time on the African continent that that kind of research was done”, she says. In 2007, she was awarded an International Fulbright Science and Technology Award for PhD studies and went on to complete her PhD in psychiatric epidemiology at Johns Hopkins University, Baltimore, MD, USA, in 2012.
Seggane Musisi, Professor of Psychiatry at MakCHS’s Department of Psychiatry, describes Nakimuli-Mpungu as “a bright and gifted scholar…She has impacted Ugandan and world psychiatry by working to improve access to care of stigmatised, marginalised, and hard to reach people with severe mental illness in LMICs.” Nakimuli-Mpungu believes the mental health focus in Uganda needs to shift. “The problem in Uganda, maybe not only in Uganda, is that our focus is on the extreme end of the mental health spectrum, severe mental disorders…I feel that we should prioritise mental health. This requires creating awareness, education, and identifying the mild cases and then you step in at that stage…All health workers need to have at least the basic knowledge; they need to learn simple mental health screening to recognise depression. And when you identify a problem, immediately do something, give them an intervention. This does not call for specialised health workers because they’re not there. But we all have mental health, and our mental health needs to be taken care of. Otherwise, it makes our physical health worse, we can’t work, so we can’t develop our communities.”
Every 4 July, the United States marks its independence. This year’s commemoration carries added significance as the country celebrates 250 years, offering partners across the world a moment to reflect on relationships built through shared purpose, investment and trust.
For Makerere University School of Public Health (MakSPH), that reflection leads to a long and productive partnership with the people and Government of the United States, spanning more than 35 years. Through U.S. Government agencies and programmes, the collaboration has supported MakSPH’s growth from a national public health training institution into a regional platform for evidence, leadership, health systems strengthening and public health preparedness.
Today, MakSPH stands at a defining point in its institutional journey. Tracing its roots to the introduction of preventive medicine in Makerere University’s then Faculty of Medicine in 1954, the School has grown into a leading public health institution in Africa, training more than 1,000 students across 12-degree programmes, working through district field training sites, contributing to national technical committees, and implementing research and capacity-building work across Uganda and more than 35 African countries.
Hon. Margaret Muhanga, then State Minister for Primary Health Care and Chief Guest, joins Makerere University leaders and partners in cutting the MakSPH@70 anniversary cake during the School’s 70th anniversary celebrations in December 2024.
Its work spans infectious diseases, maternal and child health, noncommunicable diseases, climate and health, digital health, injury prevention, universal health coverage and epidemic preparedness. While grounded in close collaboration with the Government of Uganda, especially the Ministry of Health, this reach has also been shaped by long-standing U.S. Government support. Reflecting on this shared history, MakSPH Dean Prof. Rhoda Wanyenze said the partnership has made a lasting contribution to public health capacity.
“For more than three decades, MakSPH has been privileged to work in strong partnership with the people and Government of the United States. We are grateful for this collaboration, which has made a major contribution to advancing public health training, research and practice in Uganda and across Africa. From the Master of Public Health programme to fellowships, enhanced surveillance, operational research, HIV and infectious disease work, regional networks, innovation, and programmes such as METS, this partnership has helped build the people, evidence and systems that support public health action,” Prof. Wanyenze said.
MakSPH Dean Prof. Rhoda Wanyenze speaks during the UPHIA 2025 launch in Kampala, highlighting MakSPH’s contribution to Uganda’s public health response through research, evidence and technical guidance.
Training Leaders for Uganda’s Health System
In 1994, as Uganda decentralised its administration and public services, the Institute of Public Health, now Makerere University School of Public Health, established the Master of Public Health (MPH) Full-Time programme in response to a clear workforce need for public health leaders who could manage district health systems, investigate outbreaks, conduct needs assessments and respond to emerging health challenges.
Prof. David Serwadda, Professor Emeritus at Makerere University and former Dean of MakSPH, recalls the programme was designed to fill a critical district-level leadership gap. “After a very strong needs assessment by Makerere University and the Ministry of Health, it was found that we needed to train a specific cadre of public health leaders for the districts,” he said. “We needed people with good management skills, people who could investigate an epidemic, do a needs assessment and respond to health challenges.”
Prof. David Serwadda speaks during a departmental retreat in Jinja in June 2026. He served as Director of the Makerere Institute of Public Health from 2003 to 2007 and as the first Dean of MakSPH from 2007 to 2009.
Established as a two-year programme, the MPH Full-Time was based on the Public Health Schools Without Walls model and became one of the earliest community-based public health graduate programmes in Africa. Developed through joint commitment by the Institute of Public Health, the Ministry of Health and the Rockefeller Foundation, and with technical support from the U.S. CDC, the programme placed students at district field sites to learn through apprenticeship while working on real public health problems. Other partners, including WHO and UNFPA, later provided scholarship support.
Three decades later, the MPH Full-Time programme remains one of MakSPH’s flagship contributions to Uganda and the region’s public health workforce. It has trained more than 1,000 public health professionals for leadership across districts, Ministry programmes, research, teaching, implementation and technical advisory work. Many graduates have gone on to serve as District Health Officers, commissioners, programme leaders, researchers, lecturers and public health specialists, strengthening Uganda’s health system leadership.
Fellowships That Strengthened Public Health Response
In 2002, MakSPH hosted the first direct cooperative agreement between Makerere University and the U.S. CDC, formalising the workforce development arm of the partnership. Under the Leadership and Investment in Fighting Epidemics (LIFE) initiative, the agreement launched the HIV/AIDS Fellowship Programme, which trained leaders for organisations working in HIV and AIDS. By 2014, the programme had produced more than 100 long-term fellows, more than 200 medium-term fellows, and over 3,000 short-course participants.
Graduates pose with then U.S. Ambassador to Uganda H.E. William W. Popp during the 10th graduation of Advanced Field Epidemiology Fellows and the 2nd graduation of Laboratory Leadership Fellows under the Uganda Public Health Fellowship Programme in January 2026.
The fellowship platform later transitioned into the Uganda Public Health Fellowship Programme and, through subsequent cooperative agreements in 2016 and 2021, expanded into the broader Public Health Workforce Development Programme. Led by the Ministry of Health through the Uganda National Institute of Public Health, and implemented with the U.S. CDC, districts and MakSPH, the programme now supports advanced field epidemiology, Frontline and Intermediate Field Epidemiology Training, and laboratory leadership.
Fellows are embedded within the Ministry of Health, districts and public health institutions, strengthening surveillance, outbreak investigation, HIV/TB programming, quality improvement, laboratory systems and health informatics. The Field Epidemiology Track has supported an average of about 37 active fellows, including 39 in 2024/2025. That year, fellows provided technical assistance to the Ministry and conducted 84 epidemiological studies and investigations, including work linked to Uganda’s Mpox response.
HIV Evidence That Changed Policy and Practice
UPHIA 2025 laboratory technicians undergo pre-deployment training at MakSPH, delivered with Uganda National Health Laboratory Services, ahead of field data collection on HIV and related health indicators across Uganda.
Uganda’s HIV crisis in the 1980s became one of the earliest tests of MakSPH’s public health mission. The wasting illness, then known as “Slim”, was reported in Rakai in the early 1980s and later identified as HIV/AIDS. Researchers at the Institute of Public Health, now MakSPH, helped advance understanding of the epidemic, with Prof. David Serwadda among the earliest physicians in Uganda to recognise and describe the disease.
That work grew into the Rakai Health Sciences Programme, established in 1989 through collaboration involving Makerere University, Columbia University, Johns Hopkins University, the U.S. National Institutes of Health (NIH) and partners. Over the decades, Rakai became a platform for research, surveillance, service delivery and training in communities deeply affected by HIV.
One landmark contribution showed that safe medical male circumcision reduced female-to-male HIV acquisition by about 60 per cent, helping inform HIV prevention policy in Uganda and globally. PEPFAR support also helped expand treatment in Rakai, where surveillance documented reduced mortality, lower HIV incidence, reduced orphanhood and improved community productivity.
The search for stronger prevention tools continued through MakSPH researchers, including Prof. Noah Kiwanuka, whose work in rural and fishing communities highlighted the need for better options for adolescent girls and young women. From 2022 to 2024, MakSPH managed the Makerere-Kalangala study site with UVRI-IAVI for the Gilead Sciences-led PURPOSE 1 trial, with Prof. Kiwanuka as Site Principal Investigator. The study contributed evidence on lenacapavir, a twice-yearly injectable now recognised as a major advance in HIV prevention.
Surveillance and National Decisions
Then Minister of Health Dr. Jane Ruth Aceng flags off UPHIA 2025 field teams in Kampala on 29 May 2025. The Ministry of Health-led survey is implemented with technical support from MakSPH and partners.
The partnership has also strengthened Uganda’s ability to measure the HIV epidemic and use evidence for national decisions. The Uganda Population-based HIV Impact Assessment (UPHIA) 2024/2025 is the country’s third national household-based HIV impact survey, commissioned by the Ministry of Health with technical support from MakSPH in partnership with UBOS, UVRI, and the U.S. CDC. After two earlier rounds supported by ICAP at Columbia University in 2016 and 2020, the current survey marks a shift to Ugandan leadership in implementation, analysis and use of evidence for the national response.
Funded by the U.S. Government through PEPFAR, UPHIA represents a USD 10 million investment in national evidence generation. Its results, expected in 2026, will provide updated national and subnational estimates of HIV prevalence, incidence, viral load suppression, service coverage and progress toward UNAIDS 95-95-95 targets. The survey covers 6,685 households and about 15,000 people aged 15 years and above, with additional focus on adolescents, noncommunicable diseases among people living with HIV, and barriers among those not virally suppressed.
Related surveillance work through the CRANE Survey has generated evidence on populations at higher risk of HIV and often missed by routine data. Established in 2008 with U.S. Government support through PEPFAR and implemented by MakSPH with the Ministry of Health and U.S. CDC, CRANE is one of Uganda’s longest-running HIV bio-behavioural surveillance platforms. More than USD 7 million in U.S. Government investment has supported evidence used in Uganda’s HIV Investment Case, the National HIV Strategic Plan, national bio-behavioural surveillance guidelines and UNAIDS guidance.
In its third round, conducted in 2023 and disseminated in 2024, CRANE reached 7,947 female sex workers and sexually exploited minors across 12 districts. About one in three participants were living with HIV, rising to 54 per cent among those aged 35 to 49. The survey also documented syphilis, high-risk HPV infection, violence, stigma in health facilities and high levels of depression, strengthening the case for targeted HIV prevention, treatment, mental health support, violence prevention, cervical cancer prevention and access to justice.
Then U.S. Ambassador to Uganda H.E. William W. Popp tours MakSPH exhibition stands with MakSPH and U.S. CDC leadership during the 2024 dissemination of CRANE Survey results in Kampala.
Regional Leadership, One Health and Innovation
U.S. Government support extended MakSPH’s contribution from national workforce development to regional public health leadership. In 2005, USAID, through the Higher Education for Development programme, supported the Leadership Initiative for Public Health in East Africa (LIPHEA), led by MakSPH with Muhimbili University of Health and Allied Sciences, Johns Hopkins Bloomberg School of Public Health and Tulane University School of Public Health and Tropical Medicine. The initiative strengthened leadership, competency-based training, faculty development and collaborative research across East Africa.
LIPHEA’s legacy continued through the East Africa HEALTH Alliance, which evolved into the One Health Central and Eastern Africa network and later the Africa One Health University Network (AFROHUN). These platforms brought public health, veterinary, environmental and allied disciplines into shared training and practice, helping build a workforce able to predict, detect and respond to zoonotic diseases, epidemics and other complex health threats.
The regional focus expanded further in 2012, when USAID selected Makerere University, through MakSPH, to lead the ResilientAfrica Network (RAN) under the Higher Education Solutions Network (HESN). Operating in 16 African countries through a network of 20 African universities, RAN connected African universities, U.S. partners and local innovators to strengthen community resilience to disease outbreaks, climate shocks, food insecurity, conflict and natural disasters. Through research, innovation grants, policy engagement and capacity building, it expanded MakSPH’s regional contribution to resilience science, innovation and implementation research.
METS and National Stewardship
MakSPH Dean Prof. Rhoda Wanyenze signs the METS handover board during the transition of digital health systems and assets to the Ministry of Health on 31 March 2026, as then U.S. Ambassador to Uganda H.E. William W. Popp and Dr. Diana Atwine, Permanent Secretary, Ministry of Health, look on.
A recent marker of partnership maturity came through the Monitoring and Evaluation Technical Support (METS) Programme. Launched in 2010 with U.S. Government support through the U.S. CDC and PEPFAR, METS strengthened Uganda’s health information systems, case-based surveillance, monitoring, evaluation and quality improvement for HIV, TB and broader public health programming. Across three five-year grants totalling USD 103.8 million, the programme helped move Uganda from fragmented reporting toward stronger national data systems and more integrated digital health infrastructure.
During its March 2026 handover to the Ministry of Health, METS transferred 16 digital health systems, 725 servers, more than 4,700 computing devices, solar systems for nearly 800 facilities, connectivity equipment for more than 1,300 sites, and network upgrades for regional referral hospitals. The transferred ICT infrastructure was valued at USD 9.3 million. METS also helped improve District Health Information System 2 reporting from 58 per cent in 2020 to 98 per cent by 2025, while Electronic Medical Record coverage expanded to more than 86 per cent nationally, with 1,900 sites using electronic medical records.
Infrastructure and Future Capacity
MakSPH’s new home takes shape near the Eastern Gate at Makerere University Main Campus, supported in part through the USAID ASHA grant.
MakSPH’s expanding mandate has placed new demands on its infrastructure. With more than 1,000 students, wider regional work and a growing research portfolio, the new MakSPH complex on Makerere University Main Campus is designed to support training, research, policy engagement and innovation at scale. In 2021, USAID, through the American Schools and Hospitals Abroad (ASHA) programme, awarded USD 1.1 million through Johns Hopkins University to support the Makerere University Centre of Excellence for Global Health within the new building.
The infrastructure agenda also points to the next phase of the MakSPH and U.S. Government partnership. After more than three decades of investment in leadership, evidence, surveillance, digital systems, regional networks and response capacity, sustaining these gains will require stronger shared responsibility.
As the United States marks 250 years of independence, MakSPH recognises a partnership that has strengthened Uganda’s public health system and continues to build capacity for the region.
The Makerere Bioethics Conference (MakBC) 2026 Organizing Committee is pleased to invite researchers, academics, students, practitioners, policymakers, research ethics committee members, and other stakeholders to submit abstracts and register for MakBC 2026.
Conference Theme: Evolving Trends in Global Health Research Ethics
Conference Dates: 10th – 11th November 2026 Venue: Hotel Africana, Kampala, Uganda
Conference Sub-Themes
Research in Emergency and Disaster Situations
Genetic and Genomics Research, Biobanking, and Data Governance
Research in Vulnerable Populations and Health Equity
Emerging Technologies in Research and Artificial Intelligence
Research Regulation and Research Integrity
We welcome the submission of original abstracts that address the conference theme and sub-themes. The conference will provide an opportunity for participants to share research findings, best practices, innovations, and emerging ethical issues in global health research.
Applications are invited for an exciting Master’s Scholarship Opportunity offered through a collaboration between Makerere University and Case Western Reserve University (USA).
The Biomedical Engineering Unit, Department of Physiology at Makerere University, in partnership with Case Western Reserve University, received funding from the U.S. NIH Fogarty International Center to train Ugandans in Biomedical Engineering (BME). The program aims to strengthen capacity for medical technology innovation and develop the next generation of researchers in Biomedical Engineering.
Scholarship Highlights
The scholarship supports students pursuing a Master’s degree in Biomedical Engineering or a closely related field. Eligible applicants include MSc students from:
Technology Innovation and Industrial Development (CEDAT)
Computer Science (COCIS)
Immunology and Clinical Microbiology
Master of Health Informatics
Master of Bioinformatics (CHS)
The scholarship provides:
Tuition support
A modest monthly stipend
Reasonable research funding
Support for up to one academic year (Master of Science)
Eligibility
Applicants should:
Hold a Bachelor’s degree in Engineering or a health-related field from a recognized university.
Demonstrate interest in medical devices and technology innovation.
Have a research project idea focused on:
Cardiovascular diseases,
Blood disorders, or
Chronic movement disorders.
Show evidence of good academic performance in the first year of their MSc program.
Be available for an oral interview.
Application Requirements
Submit the following as a single PDF:
Certified copies of relevant academic documents
Two reference letters
A motivation statement (maximum 500 words)
A one-page research project idea
A brief CV (maximum four pages)
Applications should be emailed to sightproject2022@gmail.com with the subject line:
“Scholarship MSc Application 2026”
Important Dates
Application Deadline: 30 July 2026
Interviews: 13 August 2026
Notification of Successful Applicants: 21 August 2026
Qualified MSc students interested in advancing research and innovation in Biomedical Engineering are strongly encouraged to apply.
General38 minutes ago
General7 days ago
General1 week ago
General2 weeks ago
Education2 weeks ago