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Researchers Recommend Drug to Win the Malaria War in Children

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Malaria is a terrible disease. It affects you beyond discharge. Once treated for malaria, you are susceptible to more infections, and the chances for re-admission are very high.”

Uganda’s fight against malaria has received a boost after medical researchers recommended that a wonder drug that has produced positive results in Uganda, Kenya and Malawi be embraced globally.

Results of the study showed that treatment with Dihydroartemisinin–Piperaquine (DP) should now be the preferred treatment for malaria in both children and adults after discharge. The trials in children indicated reduced number of deaths from severe malaria by 80 per cent. 

The study-the Malaria Chemoprevention in the Postdischarge management of severe Anemia was carried out over a two-year period at Jinja, Kamuli, Hoima, Masaka and Mubende Regional Referral hospitals and studied 1,049 children with severe malaria, which kills nearly a million people each year, mainly young children and pregnant women.

Dr. Robert Opoka, a Senior Lecturer at the Department of Paediatrics and Children Health, College of Health Sciences, Makerere University

“We focused on those hospitals because those are the areas that are most hit with Malaria.We found out that Children who have been hospitalized with severe anemia in areas of Africa in which Malaria is endemic have a high risk of readmission and death within 6 months after discharge,” said Dr. Robert Opoka, a Senior Lecturer at the Department of Paediatrics and Children Health, Makerere University College of Health Science.

Dr. Opoka noted that they allocated children with severe malaria with antimalarial during the first 3months post-discharge at 2,6 and 10 weeks and they were followed for three months and found out that 80 percent of the children on the antimalarial survived.

“It was observed that there was 70% significant reduction in either deaths or re-admissions among the children receiving the antimalarials compared to the group of children who were not on admission,” Dr. Opoka noted.

Dr. Richard Idro, Senior Lecturer, College of Health Sciences, Makerere University
Dr. Richard Idro, Senior Lecturer, College of Health Sciences, Makerere University

The study, whose findings have been published in the latest edition of the New England Journal of Medicine (NEJM), was funded by the Norwegian Research Council. It involved an international consortium of researchers. Some of the members of the research team from Makerere University College of Health Sciences included: Dr. Richard Idro, Dr. Aggrey Dhabangi and Dr. Robert Opoka

Malaria is caused by parasites that are injected into the bloodstream by infected mosquitoes. Severe malaria is often the main reason why children are admitted to hospital in sub-Saharan Africa, and one in 10 of these children die.

The Ministry of Health 25th Health Sector Joint Review report 2018/2019 showed that malaria was still the leading cause of admissions for all ages accounting for 32.9 per cent of all admissions.

Dr. Aggrey Dhabangi, Lecturer, College of Health Sciences, Makerere University

“The drug has a huge impact on reducing mortality and morbidity in children under five-years recovering from severe malaria. The children who were not on antimalarials developed respiratory distress, complicated seizures, movement disorders, vision impairment, speech and language impairments, cognitive deficits, epilepsy and destructive behavior,” said Dr. Aggrey Dhabangi, a Lecturer at the Makerere University College of Health Sciences.

Dr. Dhabangi noted that DP is available in both private and public pharmacies. And a dose goes for UGX 3,000 for children and UGX 3,500 for adults and it is supposed to be taken for 3days in a month. “(DP) is a reliably oral effective drug, and it is given to children according to weight and it should be given 14days after discharge and later after a month,” Dhabangi noted.

During the meeting held on 3rd December 2020, Dr. Richard Idro, a Senior Lecturer at the Makerere University College of Health Sciences, revealed that further studies in Malawi have demonstrated that delivery of the drugs using community-based approaches is associated with much higher adherence 24% than hospital-based approaches.

Dr. Charles Olaro, Director of Curative Services, Ministry of Health

“These children are readmitted or die because by the time they are discharged from the hospital they have not fully recovered so when they go back home especially to places with high infections, they get attacked again, but with the antimalarial they get protected until they recover and gain their immunity,” Dr. Idro noted. The researchers recommended that after discharge, the children should be given Multi-Vitamin supplementation and use mosquito nets. 

Responding to the findings, Dr. Charles Olaro, the Director of Curative Services at the Ministry of Health, said that he was happy with the research findings and promised to translate the research findings into policy so that Children in Uganda are saved.

Dr. Sabrina Kitaka, College of Health Sciences, Makerere University

“Malaria is still one of the diseases burdening clinical services, so we still need more research and innovations in that area. We need to start up a package where health workers do not only stop at discharging patients but also educate them about the post discharge,” Dr. Olaro, noted. He assured the public that the Ministry of Health had stocked enough Dihydroartemisinin-Piperaquine (DP) for public hospitals.

The Vice Chancellor of Makerere University, Prof. Barnabas Nawangwe who was represented by Dr. Sabrina Kitaka from the College of Health Sciences commended the research team comprising Makerere University researchers for creating a paradigm shift that focuses on only treatment of malaria to a preventive approach that will save lives.  The Vice Chancellor expressed Makerere University’s readiness to review the curricula to include prevention of malaria and chemo prevention in the management of malaria. Noting that the researchers focused on three (3) months after discharge, he appealed to research team to consider an option of extending the period of follow up to six (6) months so that more lives are saved.

Dr. Jimmy Opigo, Assistant Commissioner-Health Services, National Malaria Control Division (NMCD), Ministry of Health

Dr. Jimmy Opigo, the Assistant Commissioner-Health Services at the National Malaria Control Division said: “We are happy that this PMC study has enabled people to realise that treatment of malaria and discharge is not enough. There is need for longitudinal management of those discharged. The medical team and health care workers should add patient education and improve health care practices in the management of malaria.”

Article by Mak Public Relations Office

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MU-JHU Positions: Locum Midwives/Nurses – WOMANPOWER Study June 2021

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Female staff at the Makerere University –Johns Hopkins University (MU-JHU) Research Collaboration Family Care Centre. Photo credit: MU-JHU

The Makerere University-Johns Hopkins (MU-JHU) Research Collaboration – MU-JHU CARE LTD, a Kampala – based equal opportunities Clinical Research and Service Delivery Organisation with more than 350 employees is seeking interested, committed and reliable professionals with the described qualifications to apply for the Locum positions listed below in support of the EDCTP funded studies. The positions are Locum positions on short term contract for 6 months.

1. Locum Midwife/Nurse: multiple positions
    Reports To: Nurse Coordinator
    Duty station: MUJHU, Kisenyi HCIV and Kawempe National Referral Hospital

Required qualifications and profile:

A Diploma in Midwifery/Nursing, with current registration for practice from the Uganda Nurses and Midwives councils (UNMC) with interest in working in a busy labour ward with minimum supervision. The candidates are required to have worked for at least three (3) years in a busy health centre/institution. Previous work experience in a clinical research environment and/or with HIV, TB and/or MCH clinical care would be a strong advantage. Computer literacy is required. The successful candidates should be willing and able to work extended duty shifts i.e. 12 hour day, and 12 hour night shifts, including public holidays and weekends.

The holder of this position will work under the direct supervision of the Nurse Coordinator with guidance from the Head of Nursing Section, and will be responsible for the following duties:

  • Working closely with other health professionals/research staff to obtain consents.
  • Provide midwifery/nursing care to study participants as well as do phlebotomy, cord blood sampling and other sample collection as required.
  • Collect data using tablets and laptops.
  • Participate in study data quality assurance and control.
  • Any other duties reasonably assigned by the relevant authorities.
  • Maintain professional GCP/HSP accreditation and complete study specific training as required.

Applications with complete C.Vs, including 3 referees and their full addresses or contact Telephone numbers, copies of academic certificates and testimonials, should be hand delivered to: MU-JHU Human Resource Manager, through the reception on first floor, MUJHU 1 Building – not later than 25th June, 2021 by 5.30pm.

Only short-listed applicants will be contacted. Successful candidates will be expected to start work immediately.

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Psychological Services for Community Members While Home

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Female Students hold a group discussion at the Main Campus, Makerere University.

COVID-19 is a terrible disease that has brought about so many psychological challenges within the population but with many more effects to the students and the entire community. Already as students were departing yesterday they made remarks like “shall we ever finish?” “Let us go and get married” etc. They put on faces of sadness, anxiety, and many other forms of negative emotions. At their homes parents too some are having other challenges and anxieties that we need to help them deal with.

The Counselling and Guidance Centre is going to intensify its online presence as an avenue to reach out to the community. We shall do the following:

  1. With support from the College of Computing and Information Sciences (CoCIS) staff we developed an App UniCare which people can download and reach a counsellor of their choice via e-mail, telephone, chat etc at any time at their convenience.
  2. We intend to have a zoom session every fortnight addressing a topic of interest basing on the prevailing need.
  3. Yesterday we held a meeting with student leaders who promised to work with us to deliver any content we develop to students via students’ WhatsApp groups.
  4. We are going to have continuous engagements with students via the Counselling and Guidance Centre Twitter and Facebook accounts.

We lost a student (Byengyera Natasha) from the School of Law to suicide on Sunday and she will be buried tomorrow.

We want to do our best to provide all support possible using the avenues above to support members of the community and we call upon you to reach out to as many students as possible with this information. Thank you very much.

We build for the future.

Henry Nsubuga
Manager, Counselling and Guidance Centre,
Plot 106, Mary Stuart Road (Opposite Mary Stuart Hall),
Makerere University
Email: hnsubuga[at]cgc.mak.ac.ug
Tel: +256-772-558022

Click here for more information about the Counselling and Guidance Centre

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MakSPH Annual Report 2020

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Dr. Rhoda Wanyenze, Professor & Dean, School of Public Health, Makerere University.

Dear Reader,

I am pleased to introduce our 2020 Annual Report, which illustrates the Makerere University School of Public Health, (MakSPH)’s shared commitment to advancing excellence in public health education, research, and innovation in Uganda and beyond.

In the face of the COVID-19 pandemic, the School of Public Health teams working together with the Ministry of Health and other partners moved fast towards enhancing the knowledge and awareness of our communities and other public health interventions to combat the spread of COVID-19 and mitigate a public health crisis that has thrown the world into disarray. We quickly adapted to the new normal, moving to working in a virtual environment and using blended approaches, to deliver our teaching, learning and research activities.

The pandemic has been a great challenge and slowed down several activities. However, this challenge has also propelled us towards fast-tracking some of our planned advancements including virtual
learning and partnerships, and has accelerated our public health innovations in a bid to contribute solutions to the current and future public health challenges.

Research

Our research has focused on current issues to support evidence-based decision making, and mitigate the impact of the pandemic on essential health and other services, especially in vulnerable groups such as adolescents and children, refugees, among others.

Construction

In 2020, we embarked on construction of our new home that we hope will reduce the space constraints for our staff and students. I am happy to report that the construction is now under way at Makerere University Main Campus. We are sincerely grateful to our partners, sponsors and staff for the efforts towards this great move.

Community Engagement

Our teams have maintained a very active community engagement focus and working with various stakeholders to share research findings and support processes for knowledge translation. We have also maintained a high level of scientific research outputs including over 250 peer reviewed publications in 2020. I cannot thank our researchers enough for this great effort.

Grants

The number of partnerships, grants and volume of work at the School has grown within Uganda and the African region. We are very grateful to our funders; partners and stakeholders for this continued growth.

I acknowledge the extraordinary efforts made by all our staff, students and alumni. We look forward to another productive year and decade of better service to our communities.

Have a nice read.

Dr. Rhoda Wanyenze,
Professor & Dean, School of Public Health, Makerere University

Please Downloads for the full report.

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