Bacteriophage research and its applications were the focal point of the 1st Symposium on Bacteriophage Research and Applications, convened by Makerere University‘s College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB) on Thursday, March 27, 2025. This landmark event showcased Uganda’s strides in harnessing bacteriophages as innovative solutions to antimicrobial resistance (AMR) and other pressing health and agricultural challenges.
Tobi Elaine Nagel, the President of Phages for Global Health (USA), was one of the presenters.
Key speakers included Dr. Jesca Nakavuma, CoVAB (Makerere University), who showcased Uganda’s pioneering phage research initiatives and vision. Tobi Elaine Nagel, the President of Phages for Global Health (USA), discussed the global significance of phage research. Prof. Martha Clokie, from the University of Leicester’s Centre for Phage Research (UK), shared insights into the latest advancements in phage therapy. Dr. Robert Blasdel, representing VASALE (Belgium), presented innovative solutions using bacteriophages. Ms. Abigail Riggs, from the Foreign, Commonwealth and Development Office (UK), emphasized international partnerships and policy development.
Prof. Robert Wamala, Director, Directorate of Research, Innovation and Partnerships addressed the participants.
Speaking at the event, Prof. Edward Wamala, Makerere University’s Director of Research, Innovation and Partnerships, who represented the Vice Chancellor Prof. Barnabas Nawangwe at the event, highlighted the critical role of bacteriophage research in addressing the global threat of antimicrobial resistance (AMR). He explained how the misuse and overuse of antibiotics in human health, agriculture, and aquaculture have accelerated the emergence of drug-resistant bacterial strains, rendering standard treatments ineffective. Citing statistics from the World Health Organization, he pointed out that AMR claims over 1.3 million lives annually, a number expected to rise without urgent action. He lamented the stagnation of new antibiotic development due to high research costs and rapid bacterial resistance, making bacteriophage therapy a powerful and promising alternative.
A Section of the stakeholders that participated in the engagement.
Prof. Wamala expressed Makerere University’s commitment to advancing research that addresses critical societal challenges, aligning with its mission of generating transformative knowledge and fostering sustainable development. He emphasized Uganda’s potential to lead in bacteriophage research, driven by multi-disciplinary partnerships and capacity building. He also highlighted ongoing studies into aquaculture-specific bacteriophages at CoVAB as an example of how phage technology can revolutionize sectors like agriculture while addressing AMR. Through such efforts, the university aims to position Uganda as a global leader in innovative solutions to combat antimicrobial resistance and enhance public health.
Dr. Jesca Nakavuma, from the College of Veterinary Medicine, Animal Resources, and Biosecurity.
Dr. Jesca Nakavuma, widely regarded as the mother of phages in Uganda, delivered a compelling presentation at the Symposium, where she detailed the impressive progress of phage research in Uganda since its inception in 2017. She highlighted Makerere University’s pioneering efforts, starting with a cohort of five undergraduate students, which have since expanded into groundbreaking research addressing challenges in agriculture, clinical health, food safety, and environmental safety. Key achievements include advancements in E. coli and Salmonella detection, tackling avian colibacillosis, and innovations in decontamination methods, underscoring the transformative potential of phage technology in combating antimicrobial resistance and enhancing public health.
The University leadership included Prof. Robert Wamala (R) and Assoc. Prof. James Acai Okwee (C), Deputy Principal CoVAB.
The symposium honored collaborative efforts, including the establishment and accomplishments of Phage Team Uganda, which developed a repository of 125 characterized phage isolates and trained over 20 PhDs, MScs, and BSc students. Partnerships with international organizations such as IDRC InnoVet AMR and AU Safe Fish have significantly contributed to advancements in antimicrobial resistance and aquaculture.
The participants were actively involved in the discussions.
Despite these achievements, Dr. Nakavuma noted challenges such as insufficient facilities for large-scale phage production, regulatory limitations, and financial constraints. She affirmed that despite the challenges, the team remained ambitious, envisioning the creation of a fully equipped Phage Research and Development Center, the commercialization of phage products, and the establishment of policy frameworks to support the use of phages in Uganda.
The Deputy Principal of CoVAB, Prof. James Acai Okwee, warmly welcomed the partners to the conference and acknowledged their invaluable contributions to the college’s research efforts. He emphasized the importance of collaboration in driving innovation and achieving impactful results, highlighting the pivotal role that partnerships play in fostering academic and scientific growth. Prof. Okwee’s remarks set an encouraging tone for the conference, reinforcing the college’s commitment to advancing research initiatives and creating opportunities for shared learning and development.
Part of the audience at the symposium.
The event that attracted the participation of various stakeholders including academia, civil society, and policy makers, concluded with acknowledgments of the efforts of Phage Team Uganda, collaborators, and funders, setting the stage for an exciting future in Uganda’s journey to combat antimicrobial resistance and ensure food and environmental safety.
Makerere University has secured funding amounting to UGX 980 million for the construction of a student hostel at Buyana Stock Farm, a key research and training facility under the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB). The construction due to commence soon, will be undertaken by the Uganda People’s Defence Forces (UPDF), addressing a longstanding challenge of inadequate accommodation for staff and students.
The announcement was made during a handover ceremony on Thursday, 28th August 2025, where Dr. Mathias Wasswa, the long-serving Farm Manager, officially passed the mantle to Ms. Nansubuga Frances after a 19-year tenure. Dr. Wasswa was lauded for his resilience and commitment in steering the farm through resource constraints and maintaining its relevance in Uganda’s veterinary education landscape.
Left to Right: Dr. Mathias Wasswa, outgoing Farm Manager; Prof. Frank Norbert Mwiine, Principal of CoVAB; and Ms. Nansubuga Frances, incoming Farm Manager, during the handover ceremony held on Thursday.
The leadership transition marks a pivotal moment for Buyana Stock Farm, which is currently undergoing a comprehensive review and restructuring. On the same day, an audit led by Mr. Muteganda Amon, Chair of Makerere University’s Audit Committee, uncovered critical challenges, including deteriorating infrastructure, staffing constraints, and an urgent need for strategic reforms. These findings underscore the necessity of revitalizing the farm to reclaim its status as Uganda’s premier veterinary training institution.
Among the issues highlighted were the lack of student housing, a crumbling administration block, and deteriorated animal units. Other challenges included poor water supply system and animal welfare concerns, including disease outbreaks, poor pasture management, and lack of contingency plans for dry seasons. The farm also faces Governance gaps, with most workers not formally employed by the university and rigid recruitment policies leaving key roles vacant.
A section of the College and Audit Committee members during a de brief meeting following the inspection of facilities at Buyana.
The handover event was attended by key stakeholders including Prof. Frank Norbert Mwiine (Principal, CoVAB), Prof. James Acai Okwee (Deputy Principal), Ms. Nyakato Barbara (Human Resource Officer), and Prof. Robert Tweyongyere (Dean, School of Veterinary Medicine and Animal Resources).
As Ms. Nansubuga Frances assumes leadership, stakeholders have emphasized the need for a blend of technical expertise and a deep commitment to animal welfare. The transition is expected to usher in a new era of revitalization, with plans for infrastructure upgrades, improved governance, and a renewed focus on research and outreach.
Renowned academic Prof. John B. Kaneene has called for sweeping structural reforms across Ugandan universities, including Makerere University, to enhance their global competitiveness and research output. Speaking at a forum on science and innovation, held on August 26th at the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Prof. Kaneene emphasized the urgent need for improved facilities to support active research participation.
He urged institutions to revamp their reward systems, noting that scholars who achieve significant milestones should be recognized in line with their contributions. “Success must be incentivized,” he said, adding that such recognition would motivate researchers and elevate academic standards.
The guest lecture was held under the theme “Industrial Biomedical Research and Innovation: Lessons from Michigan State University for Uganda’s New Industrial STI Dispensation.” The session explored the transformative role of universities in enhancing human wellbeing, societal development, and economic growth. It offered critical insights into institutional frameworks such as tenure and promotion, innovation and research ecosystems, and mentoring and incentive structures—drawing valuable lessons from Michigan State University to inform Uganda’s evolving science, technology, and innovation landscape.
Prof. John B. Kaneene from Michigan State University was the Guest Speaker at the Science and Innovation forum at CoVAB, Tuesday, 26th August 2025.
At the discourse attended by scientists, prodigy Scientists, administrators, and regulators of Scientists, Prof. Kaneene also criticized the current promotion framework, calling for stricter, merit-based criteria free from political interference. He proposed a more rigorous system for academic progression, from Assistant Lecturer to Lecturer, Senior Lecturer, and ultimately Professor. “The title of Professor should be earned through demonstrable excellence in both research and teaching,” he stated, arguing that current standards fall short.
In addition to structural reforms, Prof. Kaneene highlighted the need to improve the quality and quantity of academic publications. He advocated for a shift from basic science to industrial and translational research, where universities produce innovations that directly benefit public health and economic development. “We must bridge the gap between research and real-world solutions,” he said.
Prof. Kaneene concluded by urging the Ugandan government to recognize universities as engines of national progress. He called for increased funding, better infrastructure, and targeted support for top scientists. “With the right investment, our universities can drive economic growth and improve the health of our communities,” he affirmed.
Speaking at the opening of the event, Ms. Brenda Nakazibwe, Bureau Chief, Pathogen Economy at the Science, Technology and Innovation (STI) Secretariat under the Ministry of Science, Technology and Innovation, reiterated the government’s commitment to advancing Uganda’s pathogen economy and strengthening its scientific research ecosystem. She highlighted the Secretariat’s role in supporting research development and fostering ecosystem establishment as Uganda moves toward sustainable growth. She emphasized that the bureau is actively working to position science and innovation as key drivers of economic transformation.
Ms. Nakazibwe commended the presentation by Prof. John B. Kaneene, a distinguished U.S.-based academic, describing his insights as highly relevant to both scientists and the general public. She acknowledged his longstanding contributions to Uganda’s scientific landscape, particularly his involvement in the foundation of the STI Open Platform (STI OP), formerly known as the Presidential Scientific Initiative on Epidemics (PRESIDE). The PRESIDE initiative was instrumental in fast-tracking research and innovation in vaccines, drugs, and therapeutics in response to emerging diseases and public health threats.
She further emphasized the importance of the issues raised during the discussion, including innovation, research incentives, academic tenure, and promotion systems. Ms. Nakazibwe described these as “tangible and actionable areas” that must be addressed across all levels of Uganda’s scientific and academic institutions.
“These are not abstract ideas and practical reforms that can strengthen our research culture and ensure our scientists are empowered to deliver solutions for national development,” she stated.
(L) Prof. Enock Matovu, Director CEBIGH, where the discourse was hosted.
While introducing Prof. John B. Kaneene, Prof. John David Kabasa emphasized that the discourse stemmed from a longstanding consortium between universities in the United States and Africa. This partnership has been instrumental in driving major advancements in Uganda’s veterinary and biosecurity sectors. Speaking at the strategic engagement on science and innovation, Prof. Kabasa highlighted the consortium’s focus on capacity building in the integrated management of transboundary diseases and zoonoses, noting that it laid the foundation for transformative change in the country’s scientific and academic landscape.
He noted that the partnership’s strength and future-oriented vision led Makerere University to approve a development strategy and investment plan that upgraded its Faculty of Veterinary Medicine into the College of Veterinary Medicine, Animal Resources and Biosecurity. “Biosecurity became central to our mission because we are focused on global biosecurity,” Prof. Kabasa said.
Prof. John David Kabasa explained that the discourse stemmed from a longstanding consortium between universities in the United States and Africa.
Over the past 15 years, he said, the consortium has yielded significant milestones, including the establishment of a Master’s program in Biosecurity, ongoing development of a PhD in Biosecurity, and the creation of a Centre for Biosecurity and Global Health. These efforts are now being aligned with the Ministry of Science, Technology, and Innovation to promote Industrial Biomedical Research and Innovation, key pillars of Uganda’s emerging industrial bioeconomy under the pathogen economy framework championed by His Excellency, the President of Uganda.
Prof. Kabasa, alongside Prof. John B. Kaneene and other founding scientists, announced plans to elevate the consortium’s work to a new level, with a renewed focus on global biosecurity and industrial bioeconomy. He revealed that partners mentored through the original initiative, including directors from the National Agricultural Research Organisation (NARO), senior scientists at the ministry level, and academics from other universities, are injecting fresh energy into the collaboration.
“We are now engaging to define how universities can lead national transformation, and what strategic steps they must take to reposition themselves,” Prof. Kabasa stated. He confirmed that a series of follow-up meetings will be held to chart the path forward.
Dr. Monica Namayanja, Centre Manager CEBIGH.
The Centre for Biosecurity and Global Health (CEBIGH) is one of the specialized units established at Makerere University, whose creation is part of a broader vision to develop a regional veterinary college through the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB). As a key research and development entity, CEBIGH is instrumental in repositioning CoVAB as a leading driver of scientific innovation, strategic research, and public service nationally and globally. Through its work, CEBIGH is emerging as a major contributor to Uganda’s growing pathogen economy.
A team of scientists under the regional research initiative “Building Capacity for Innovation and Advancement of Climate Smart Agriculture in East and Southern Africa” (CICSA-E&SA) visited Mr. Mugisha Jonan, an urban farmer and environmentalist in Sentema Wakiso District, whose adoption of innovative practices is redefining the feasibility of farming in densely populated urban settings.
Mr. Mugisa, a farmer and environmentalist explains how he started his farm and took on the use of the innovation.
Through the Nutrient Recycling Innovation, Mr. Mugisha has not only resolved the persistent issue of odor from his dairy farm, but is also unlocking more profitable outcomes by embracing climate-smart agricultural techniques. Central to his approach is the use of VTC Technology, a system designed to recover nutrients from diverse waste streams, including farm and market waste, and return them to their original sources. This transformative method was introduced to him by Dr. Herbert Mukiibi, a renowned scientist from the College of Veterinary Medicine, Animal Resources and Biosecurity at Makerere University.
The Scientists inspect the innovation where wastes are dumped and will eventually turn into manure.
Based on the demonstration on the farm, the innovative practice will help in reshaping urban agriculture by enhancing sustainable food production while simultaneously addressing critical environmental challenges such as waste management and odor control. Mr. Mugisha’s work stands as a compelling example of how local science-driven solutions can empower urban farmers and contribute to greener, more resilient cities.
Prof. Asaete, Dr. Nampanzira, Dr. Herbet Mukiibi were conducted around the vegetable garden where the manure is applied.
Dr. Dorothy Nampanzira Kalule led a team that included Dr. Herbert Mukiibi, the innovator who collaborated directly with Mr. Mugisha to implement the nutrient recycling innovation. Also part of the team was Prof. Josephine Esaete from the College of Education and External Studies, part of the members of the bigger project research team that includes Prof. Robert Stephen Tabuti and Prof. Vincent Muwanika, both from the College of Agricultural and Environmental Sciences (CAES) at Makerere University.
“Mr. Mugisha’s work exemplifies the kind of innovation we aim to capture, document and validate as solutions that are proven to work, locally driven, environmentally sound, and socially inclusive,” said Dr. Nampanzira, following a tour of the project site nestled within a densely populated urban residential area.
Dr. Nampanzira said the reason for the visit to the farmer was because through the project, scientists were looking out for farmers doing unique things that actually give them good results which are not known to the scientists. She said the purpose was to validate such practices and have them promoted.
A vegetable garden with a high yield.
The project, Building Capacity for Innovation and Advancement of Climate-Smart Agriculture in East and Southern Africa (CICSA-E&SA), continues to engage with farmers who have adopted some climate-smart agricultural practices by identifying and supporting solutions that work for farmers on the ground. Through hands-on engagement and collaboration, the initiative focuses on practical innovations that address real challenges, ensuring that climate-smart agriculture is not only sustainable, but also accessible and effective for local communities.
While describing the innovation demonstrated by Mr. Mugisha, Dr. Herbert Mukiibi explained that the Nutrient Recycling Technology is designed to recover nutrients from various waste streams such as domestic, farm, hospital, schools or market waste and return them to their original source. If the nutrients came from the garden, the ultimate goal is to return them to the garden, Dr. Mukiibi noted. He said that most systems release nutrients through waste, which wastes are often mistreated because people don’t realize they are valuable resources. He said through such interventions, they were coming in to tap on these wastes and return them to the garden in a ready form that can be used by the crops for better yields without necessarily using inorganic forms of fertilizers.
Dr. Mukiibi emphasized that this technology not only promotes sustainable agriculture but also transforms public perception of waste, from a nuisance into a valuable resource thereby encouraging more responsible and productive environmental practices. He commended Mr. Mugisha, the farmer behind the initiative, for embracing the technology and personally financing its development. Thanks to Mr. Mugisha’s commitment, the project has advanced to the point where it is nearly ready to produce, package, and sell organic manure, marking a significant milestone in practical nutrient recycling.
“We want to document the various innovations that promote climate-smart agriculture while simultaneously addressing farmers’ real-world challenges,” said Prof. Asaete Josephine, who is part of the research team. “The innovation demonstrated by Mr. Mugisha not only solved his initial problem, the unpleasant smell of dung that was causing concern in the neighborhood, but also evolved into a broader solution. What began as an effort to manage odor has also addressed nutrient deficiencies. That’s where the climate-smart aspect comes in, she noted. Instead of spending resources on inorganic fertilizers, the farmer is now benefiting from nutrient recycling, which promotes faster plant growth while tackling the original issue of odor.”, she noted.
Mr. Mugisha explains the Innovation that has helped him resolve the challenge of waste and odor management on his farm.
Mr. Mugisha informed the visiting team that he initially started the farm to meet his family’s nutritional needs. However, as the farm grew, he encountered significant challenges related to waste management, which led him to connect with Dr. Herbert Mukiibi, whose expertise helped guide him toward innovative solutions. He said he first adopted biogas technology yet, odor problem persisted, leading him to explored more sustainable options and eventually embraced the nutrient recycling innovation. He said transforming waste into organic manure enabled him resolve the environmental concerns but also enhanced the productivity of his vegetable gardens, and is moving towards packaging and sale of organic manure.
The team interacts with Mrs. Mugisha (R). In the background is the slab where the manure will be dried before further processing and packaging.
The CICSA-E&SA project is a multi-institutional collaboration led by Makerere University, in partnership with the Norwegian University of Life Sciences (Norway), Maseno University (Kenya), and LUANAR and DARS (Malawi). The project is funded by the Norwegian Agency for International Cooperation and Quality Enhancement in Higher Education (Diku) and aims to promote climate-resilient agricultural practices across East and Southern Africa.