The Principal Investigator for the Implementation Science Capacity Building grant, Prof. Moses Kamya (Left) being bestowed upon the Elise and Walter A. Haas International Award by the University of California, Berkeley. Photo: MakIms-MakBSSR
Strengthening Implementation and Behavioural Social Sciences in HIV research
Local healthcare providers see the impact of HIV/AIDS, its associated comorbidities and stigma across different age spectrums daily. As research into the development of an HIV cure continues to advance globally, the field has expanded to include implementation science and behavioral social sciences research.
We know that HIV/AIDS is intricately interwoven with an individual’s behavior and social context. Therefore, addressing it solely through biomedical interventions such as drugs and vaccines would be falling short of bringing the epidemic under control. Involving aspects of behavioral and social sciences is critical in helping us to understand how health attitudes, social cognitions and personal habits shape one’s decisions and practices as regards HIV prevention and treatment.
Under the Makerere University Behavioral Social Sciences Research (BSSR) program, we are training a number of early career researchers in order to leverage on the benefits of BSSR to lower HIV incidence and increase treatment coverage rates. As reflected in the various stories shared in this newsletter, fellows research on issues such as the interplay between alcohol use and HIV care is helping to integrate evidence based social behavioral approaches into biomedical care.
Similarly, implementation science is an expanding field within HIV/AIDS research and public health practice. Through it, researchers aim to close the gap between theory and practice by addressing barriers that delay uptake of proven health interventions. Through the Makerere University Implementation Science (ImS) Program, more than 50 young scientists are being trained to optimize the public health impact of efficacious interventions such as test-and-treat and pre-exposure prophylaxis (PrEP) for eligible populations. In this newsletter, you’ll acquaint yourself with the ImS program aims, activities and fellows’ research.
As our fellows on the BSSR and ImS program continue to excel, we envision enhancing capacity for HIV research and care in Uganda and Africa at large. I am pleased to present to you the novel ImS/BSSR newsletter that brings you exhilarating insights into the programs’ activities and achievements. Enjoy your reading!
Highlights
Prof. Moses Kamya Awarded the Elise and Walter A. Haas International Award
Prof. Kamya was awarded for his outstanding contribution in the field of research and teaching infectious diseases with a particular interest in malaria and HIV. He is past chair of the Department of Medicine and past Dean of the Makerere University School of Medicine in Kampala, Uganda. He is a founding member of the Makerere University Joint AIDS Program (MJAP), the Infectious Diseases Institute (IDI), and the Infectious Diseases Research Collaboration (IDRC) in Uganda.
Building Implementation Science Capacity to Strengthen the Response to the HIV/AIDS Epidemic in Uganda
The Makerere University School of Medicine Implementation Science (Mak-ImS) Training program, funded by the United States National Institutes of Health-Fogarty International Center is a collaboration between Makerere University College of Health Sciences (MakCHS) and University of California San Francisco (UCSF)-USA. This program focuses and integrating ImS as a field of study at Makerere University; influencing HIV practices and enhancing the cascade of HIV care in Uganda.
ImS Program staff hold two-day training for Walter Reed Staff
On November 14 and 15 2022, Directors, Heads of Department and departmental staff of Makerere University Walter Reed Program (MUWRP) underwent an intense training in implementation science (ImS), a field of study that enables research uptake into practice. The training purposed to equip MUWRP staff with knowledge on various concepts of implementation science such as its principles, study designs and evaluation frameworks.
Dr. Geetha Bansal visits ImS fellows in Uganda
On Thursday 18 May 2023, fellows, mentors and mentees on the Implementation Science Program met and interacted with Dr. Geetha Bansal, Program Director, HIV Research and Training Programs at the National Institutes of Health.
Emerging researchers share exciting study projects
On Friday the 13th of October 2023, the Makerere-Implementation Science (MakImS) program conducted a trainees’ progress review meeting to track advancement of trainees’ PhD, masters and fellowship research projects. The review meeting attracted over 40 participants including trainees, principal investigators, university faculty and mentors.
Dr. Amadriyo presents abstract @ the 18th AOGU Conference
Dr. Emma Amadriyo, a master’s trainee on the ImS program presented her abstract titled, titled “Missed opportunities for eMTCT among mothers living with HIV whose infants seroconverted in Masaka Regional Referral Hospital – A retrospective cohort analysis” at the 18th annual scientific conference of the Association of Obstetricians and Gynaecologists of Uganda (AOGU)
Testimonials from ImS -Alumni
SSUNA BASHIR, postdoctoral fellow at Yale University and Makerere University
AHMED KATUMBA, Supply Chain Specialist in QED Group LLC.
SUSAN NAKUBULWA, applying ImS Frameworks in research and the utilization of Community Engaged Research to enable smoother translation of evidence into practice
JOAN NANGENDO, Training Coordinator, Mak-ImS program
DR. NELSON KALEMA, mentoring and supporting scientists towards the application of implementation science approaches
DR. LILLIAN TUGUME, used knowledge and skills to complete Mmed dissertation that explored the willingness of serodiscordant couples to accept pre-exposure prophylaxis
Strengthening Behavioral and Social science Research capacity to address evolving challenges in HIV care and prevention in Uganda
Spearheaded by Professors Moses Kamya, Anne Ruhweza Katahoire and Carol Suzanne Camlin, MakBSSR leverages on existing collaborations among social, behavioral, and biomedical scientists at Makerere University and its HIV programs, and the University of California, San Francisco (UCSF). Currently, five PhD candidates, 14 masters’ fellows and eight fellowship candidates are being supported by the project.
Q&A With Dr. Namisi Charles Patrick
Dr. Namisi’s PhD study, funded by the Behavioral Social Science Research (BSSR) Program of Makerere University, seeks to develop and validate a stigma mastery model for PLHIV. He is the acting Dean of the Mother Kevin Post Graduate Medical School of Uganda Martyrs University, Nkozi.
Musanje aims to develop a customized mindfulness intervention for adolescents living with HIV
This research aims to culturally adapt a mindfulness and acceptance therapy in Uganda; explore acceptability of a Mindfulness and Acceptance Based Interventions (MABI) among adolescents (15-19 years) in Uganda; evaluate the effectiveness of a MABI on improving mental health among ALHIV and evaluate the effectiveness of a MABI on improving adherence to antiretroviral treatment among ALHIV. The research was conducted at Kisenyi Health Centre IV and Kitebi Health Centre III.
Regina Ndagire credits the BSSR Program for equipping her for the working world
She is applying the research skills obtained on the program in her current role as a research officer at Clarke International University. Here, she supports students and faculty in research; conducts research training; supervises research and engages in the writing of research policy documents and grants.
Using virtual support groups to improve ART adherence among adolescents – Kiirya’s Journey
Her study seeks to explore the acceptability, feasibility and effectiveness of online peer support groups to improve adherence among YLHIVA in Kampala. It is being conducted among 402 youths attached to Kisenyi and Kawaala Health Centre IVs and Kiswa and Komamboga Health Centre IIIs.
Lived experiences, perceptions & HIV care outcomes among young people living with HIV in South Western Uganda
Dr. Raymond Felix Odokonyero is psychiatrist at Mulago National Referral Hospital and lecturer at Makerere University’s College of Health Sciences. His research interests lie in understanding the interplay between alcohol use and HIV care among young people living with HIV (YPLHIV).
Nante Rachel Wangi
Wangi interested herself in studying Assisted Partner Notification (APN) among people who have severe mental illness (SMI), who are living with HIV (PLHIV) at Butabika National Referral Mental Hospital. She conducted a mixed methods study, quantitatively examining 125 medical files of PLHIV with a diagnosis of SMI between 2018 and 2021. Additionally, ten in-depth interviews with patients and six key informant interviews with health workers were conducted to determine socio-cultural barriers to APN uptake.
Students and researchers from Makerere University and other institutions pitched 12 innovations addressing challenges in healthcare, clean energy, agriculture, waste management and community resilience during the inaugural Falling Walls Lab Kampala, held at the School of Public Health Auditorium, Makerere University.
The competition brought together emerging innovators to present solutions to practical challenges through a three minute pitch, followed by questions from a panel of judges.
Modelled on the Falling Walls format that originated in Berlin, the event required each participant to identify a “wall” a problem or barrier, and demonstrate how their innovation seeks to break it down.
Mudhasi wins with newborn jaundice screening device
Andrew Mudhasi of Makerere University emerged as the overall winner with a score of 90 per cent for a low cost medical device designed to improve newborn jaundice screening across different skin tones.
Overall competition winner Andrew Mudhasi (left) receives his first Place award certificate for his innovation
Mudhasi explained that the device uses optical sensor technology and a skin tone targeting algorithm to provide a rapid reading, with the aim of helping nurses and clinicians identify jaundice more efficiently.
During questions from the jury, Mudhasi said the device had not yet been tested on actual babies but had undergone laboratory testing using simulated skin tones.
He reported an accuracy rate of 94 per cent when the device was compared with laboratory spectrophotometers.
The innovation is intended initially for use in clinics and hospitals, with Mudhasi saying the team is also considering a version that could eventually allow mothers to screen babies at home.
Mudhasi’s innovation has previously received recognition at the African Business Concept Challenge and the iF Design Student Award, according to his presentation.
Rhonda’s innovation tackles diaper waste
Rhoda John of the University of Nairobi emerged in second place with 89.6 per cent for an innovation addressing the problem of used diaper waste.
Rhondah John pitches her innovation repurposing diaper waste into soil moisture retention
Under the theme “Breaking the wall of diaper waste and drug soils,” Rhonda explained that her team extracts sodium polyacrylate, the absorbent polymer found in diapers, and replaces the sodium with potassium.
The resulting potassium based superabsorbent material is designed to act as a “water battery” in soil by absorbing and retaining water for plants during dry periods.
John said testing showed a 99 per cent increase in germination and a 23 per cent increase in drought resistance.
The innovation also seeks to reduce the amount of used diapers ending up in landfills and the environmental effects associated with their decomposition.
During the question and answer session, John explained that her team was working with government environmental officials in Nairobi on a pilot collection system to address the challenge of gathering used diapers at scale.
Mahera takes third place with herbal peptic ulcer treatment
Stuart Mahera of Makerere University finished third with 86.2 per cent for a herbal formulation targeting peptic ulcers.
Stuart Mayira (left) receives his 3rd Place award certicate at the school of Public Health Auditorium.
Presenting under the theme “Breaking the wall of Nature and Modern Medicine,” Mahera argued that conventional treatment for peptic ulcers can involve multiple medicines and may be associated with side effects and antimicrobial resistance.
His proposed formulation, MARAC capsules, is intended as a monotherapy, combining properties required for peptic-ulcer treatment in a single capsule.
Mahera said his team had carried out quality control work, including characterisation and dose quantification, and had conducted preclinical trials on laboratory mice.
He also told the jury that an application had been submitted to the National Drug Authority as the team awaits the next stage of the regulatory process.
According to Mahera, the proposed seven day treatment would cost about Shs21,000, compared with the existing 14 day treatment approach.
Innovators present solutions to practical challenges
The remaining presentations covered a wide range of challenges.
Esther Nakungu of Utamu University presented Agri-Track, a digital record keeping solution intended to improve visibility, accountability and management of farm operations and financial information.
Dr. Jimmy Chachiga, a Makerere University participant, presented a solar photovoltaic cooker with a heat storage system designed to provide a cleaner and more reliable cooking option during both sunny and non sunny periods.
His presentation focused on reducing dependence on biomass fuels and addressing the challenges associated with intermittent solar energy.
Abdul Noor Luttamaguzi, a PhD student and senior government fisheries officer, presented a mobile application aimed at helping fish farmers and extension officers report, track and manage disease outbreaks.
Henry Duke Tamale presented a herbal cream targeting antibiotic resistant biofilm infections associated with diabetic foot ulcers.
Marvin Seruwu proposed adapting existing near infrared brain monitoring technology to help detect extra-axial brain bleeds in health facilities where access to CT and MRI equipment is limited.
His proposal seeks to repurpose existing technology towards a diagnostic need that could be particularly important in settings where advanced imaging facilities are not readily available.
Kennedy Kisame presented a poultry alert and diagnosis system combining satellite weather information with computer vision disease detection. The proposed system could be accessed through a smartphone application, SMS or USSD, making it potentially usable by farmers with limited internet access.
Frank Atwiine proposed a solar powered mobile diagnostic van designed to bring ultrasound and other diagnostic services closer to rural communities.
Johnson Makmot, a software and blockchain developer, presented a platform that combines GPS tracking and blockchain-based tokens to incentivise and verify plastic-waste collection in Kampala.
Dr. Nelson Ndugu, from a partner university, presented an artificial intelligence tool designed to translate agricultural research publications into local Ugandan languages and generate voice notes for radio-based extension delivery.
The final presentation came from Dr. Juliet Akola, a Ugandan post doctoral researcher at Mangosuthu University of Technology in South Africa.
Akola presented a community digital resilience initiative focused on mapping risks in Kampala’s informal settlements, including flooding, fire, poor sanitation, waste management and inadequate infrastructure.
Her proposal seeks to combine local community knowledge with geographical information systems and link identified risks to action plans involving municipalities and other stakeholders.
Nawangwe calls for more investment in innovation
Closing the event, Prof. Nawangwe congratulated all the participants and described their presentations as an important beginning for Makerere University, Uganda and the wider region.
Vice Chancellor, Prof. Banabas Nawangwe giving his remarks
Drawing on his experience attending the Falling Walls conference in Berlin, the Vice Chancellor said initiatives of this nature are important because innovation will play a major role in determining the future of countries.
He encouraged participants to make their pitches more precise by clearly identifying the problem they are addressing, explaining their proposed solution and demonstrating what they have already achieved.
Prof. Nawangwe also welcomed the participation of innovators from other universities and countries, noting that the Kampala event had attracted participants beyond Makerere.
He thanked the Africa Office of the Falling Walls Foundation for its role in bringing the initiative to Makerere and encouraged continued support for innovation.
The Vice Chancellor further linked innovation to Uganda’s growing youth population and the need to develop home-grown solutions to address challenges such as youth unemployment.
The inaugural Falling Walls Lab Kampala ultimately provided a platform for innovators to move ideas beyond the classroom and laboratory and demonstrate how research, technology and creativity can be applied to challenges affecting communities.
What will it take for Uganda’s health financing to match the scale of its ambitions? How does a nation ensure that the systems it builds are ones the government can fully own, sustain, and grow? And who are the leaders being shaped today to carry this work into the future?
The inaugural issue of the Makerere University School of Public Health (MakSPH) newsletter follows these questions through six months of research, partnership, and institutional growth. Inside: MakSPH’s role in the national dialogue on sustainable health financing; the milestone handover of 16 MakSPH-METS digital health systems, built over 15 years, to Ministry of Health stewardship; and the research and academic investment shaping the School’s next phase of growth.
The edition also covers Vice-Chancellor’s Research Excellence Awards for MakSPH faculty, a new CARTA doctoral cohort, progress on the School’s new building, fresh leadership in the Department of Disease Control and Environmental Health, expanding partnerships in malaria, environmental health, and maternal care, and MakSPH students stepping into leadership across Makerere‘s 92nd Guild Government.
Research has the greatest value when it moves beyond publication to improve lives.
At Makerere University’s Centre of Excellence for Maternal, Newborn and Child Health (MNCH Centre) housed at Makerere University School of Public Health, research, partnerships and innovation are being translated into action to strengthen reproductive, maternal, newborn, child and adolescent health (RMNCAH) in Uganda and beyond.
Welcome to the September MNCH Centre e-Post 135.
This month, we spotlight how evidence is informing action across reproductive, maternal, newborn, child and adolescent health (RMNCAH) at the centre.
Explore how Centre researchers and partners are advancing innovations to reduce early perinatal mortality, how Makerere University through the Centre and WHO are strengthening capacity to monitor health inequalities, and how the Centre and its partners are leveraging AI to strengthen health systems and improve malaria surveillance.
Discover what these innovations could mean for scale, stronger health systems and greater impact.