Rabies Exposure Assessment & Contact Tracing App (REACT), another milestone in rabies surveillance in Uganda; A status update of the implementation of the eRabies project
The eRabies project was launched in March 2023 at the Centre for Biosecurity and Global Health, Makerere University. To date, a lot has been realized through several stakeholders working together toward the global goal of eliminating dog-mediated rabies by 2030.
This project is a collaboration between Makerere University‘s College of Veterinary Medicine, Animal Resources and Biosecurity, and the Universities of Zurich and Bern, and funded by the Swiss National Science Foundation.
The four-year intervention through its seven work streams was initially implemented in the Districts of Kampala, Soroti, and Kyegegwa and has stretched to include Arua, courtesy of other stakeholders including the NGO Mission Rabies that came on board along the way.
By the time of the launch, the stakeholders involved included Makerere University College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), School of Public Health, College of Health Sciences, and the Infectious Diseases Institute (IDI), working in collaboration with the Universities of Bern and Zurich from Switzerland.
Prof. Sonja Hartnack from the University of Zurich spoke at the project launch at CoVAB.
According to Prof. Sonja Hartnack, from the Vetsuisse Faculty, University of Zurich, the project has addressed several work packages in addition to the initial Surveillance systems and integrated dog bite case management. During a project brief with staff at the College of Veterinary Medicine, Animal Resources and Biosecurity recently, it was revealed that the four-year project has made great strides as evidenced by the outcomes of several workshops conducted.
Prof. Sonja Hartnack said further to efforts towards the electronic surveillance of dog bites which started with the launch workshop held in August 2023, another workshop was held in Arua on May 2-3, 2024 for the pilot of the REACT App, a tool created by CDC and Mission Rabies for Integrated Bite Case Management. REACT is the abbreviation for Rabies Exposure Assessment & Contact Tracing App. The workshop brought together stakeholders from both animal and human health sectors, drawn from the district to national levels. During the workshop, there were in-depth discussions regarding the current rabies surveillance system across the four target districts in Uganda. The meeting explored how the REACT App can enhance the integrated bite case management system and data management process in rabies.
Participants at the e-rabies surveillance workshop in Arua, May 2nd -3rd, 2024. (Courtesy photo)
Prof. Sonja Hartnack who was in the company of CoVAB’s Terrence Odoch and Prof. Clovice Kankya said the pilot was to focus on integrated bite case management. This is the very first part which is still ongoing and there were concrete follow-up plans to try and foster this integrated bite case management. The Data to be collected was from both the point of view of the human-dog bite victim, but also captures whether the dog was vaccinated, provoked, killed, and a sample taken, all adding up in a true multi-sectoral and one health approach, she observed.
For the second work package which is about community engagement for rabies vaccination and dog bite prevention, she said there was already one Master’s student thesis submitted following both a qualitative and quantitative approach, and currently the student was finalizing the manuscript. Similarly, a paper on the Barriers to Vaccination at the community level and responsible dog ownership on the perceptions of dog owners was also written.
Participants discussed strategies for effective implementation of the intervention.
The other studies she said, focused on the identification of one strategy through a sensitization campaign. This would include many respects including mobilizing dog owners to bring their dogs for mass vaccination on selected days and places. Such places like Schools, she said, would enable educating the children. The other option would be conducting mass vaccination campaigns integrated with livestock activities whereby the communities will be asked to come with their dogs close to a point in the farm or to organize jointly with the human health activities.
Participants from the implementing districts of Kyegegwa, Soroti, and Kampala where some of the interventions are ongoing.
Makerere University convened a symposium to explore bacteriophage applications in combating antimicrobial resistance (AMR) and addressing health, agricultural, and environmental challenges. Organized by The Alliance for Phage Research and Development Uganda Ltd (PhageTeam Uganda), the event brought together researchers from Makerere University, Kyambogo University, Kampala International University, and Ian Clarke International University, and other players, highlighting a collaborative approach to tackling global and local issues.
Day two of the symposium saw researchers and policy makers together with partners from the UK and USA hold a discourse on the best way forward in the promotion of bacteriophage research and production in the country to support efforts against anti-microbial resistance.
Dr. Jesca Nakavuma, the lead phage researcher from the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), gave the background to the workshop.
Speaking at the event held at Hilton Garden Inn, Dr. Jesca Nakavuma, the lead phage researcher from the College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, stressed the urgent need for alternative antimicrobial agents due to the rise in drug resistance and limited discovery of new antibiotics. Bacteriophages, natural viruses that target bacteria, she said, were identified as a promising solution to revolutionize disease control, treatment, and food security. She said research in this area was key because humankind was at risk of the impending calamity of life-threatening treatment failure.
Prof. Robert Wamala, represented the VC, Prof. Barnabas Nawangwe.
Prof. Robert Wamala, Makerere University‘s Director for Research, Innovations, and Partnerships, who spoke on behalf of the Vice Chancellor, Prof. Barnabas Nawangwe, underscored the importance of building local capacity in phage research. He noted that such efforts could enhance Uganda’s resilience against AMR and yield homegrown solutions for human, animal, and crop health.
As the world grapples with the growing threat of antimicrobial resistance (AMR), bacteriophage research offers a promising alternative. Phages, which are natural enemies of bacteria, have the potential to revolutionize the approach to treatment, disease control, and food security, he noted. He said building local expertise in phage application can enhance Uganda’s resilience against AMR and produce sustainable homegrown solutions to health and environmental challenges.
A section of the stakeholders who participated in the discourse listened attentively.
Prof. Robert Wamala said Makerere University was committed to supporting cutting-edge research and innovation that addresses national and global challenges in line with the university’s role in knowledge generation, technology advancement, and policy influence. The importance of regulatory institutions, he said, cannot be overemphasized in this endeavor, since they enforce compliance, uphold ethical standards, and foster an enabling environment for impactful research and innovation. He said the engagement presented an opportunity to strengthen collaboration between researchers, institutions, and regulatory bodies to ensure that the outcomes are scientifically sound and are aligned to the national development priorities and global best practices.
Dr. Claire M. Mugasa, the Dean of the School of Biosecurity, Biotechnical and Laboratory Sciences (SBLS), CoVAB reiterated the fact that antimicrobial resistance was on the rise in Uganda and Africa, more than elsewhere in the world. She said it was time now that efforts be intensified in looking for sustainable options to curb the dangerous trends. She said this cuts across the human and the animals. She said it was an opportune time for players to come together to find ways of getting the required alternative. She said by coming together, the different ideas developed individually would in a concerted effort, pulling resources together for a way forward.
Dr. Claire M. Mugasa, the Dean of the School of Biosecurity, Biotechnical and Laboratory Sciences (SBLS) addressed the meeting.
During the discourse, several subjects were addressed, including an introduction to antimicrobial resistance, phage biology, phage application, and lessons learnt from the establishment of a phage research centre in the UK, which was presented by Prof. Martha Clokie from the University of Leicester. This initiative reflects a commitment to fostering innovation, collaboration, and regulatory compliance, positioning Uganda as a leader in sustainable solutions for global challenges.
The symposium was sponsored by Global AMR Innovation Fund (GAMRIF), through a grant to the UK Medicines and Healthcare products Regulatory Agency (MHRA) in partnership with Phages for Global Health.
Bacteriophage research and its applications were the focal point of the 1st Symposium on Bacteriophage Research and Applications, convened by Makerere University‘s College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB) on Thursday, March 27, 2025. This landmark event showcased Uganda’s strides in harnessing bacteriophages as innovative solutions to antimicrobial resistance (AMR) and other pressing health and agricultural challenges.
Tobi Elaine Nagel, the President of Phages for Global Health (USA), was one of the presenters.
Key speakers included Dr. Jesca Nakavuma, CoVAB (Makerere University), who showcased Uganda’s pioneering phage research initiatives and vision. Tobi Elaine Nagel, the President of Phages for Global Health (USA), discussed the global significance of phage research. Prof. Martha Clokie, from the University of Leicester’s Centre for Phage Research (UK), shared insights into the latest advancements in phage therapy. Dr. Robert Blasdel, representing VASALE (Belgium), presented innovative solutions using bacteriophages. Ms. Abigail Riggs, from the Foreign, Commonwealth and Development Office (UK), emphasized international partnerships and policy development.
Prof. Robert Wamala, Director, Directorate of Research, Innovation and Partnerships addressed the participants.
Speaking at the event, Prof. Edward Wamala, Makerere University’s Director of Research, Innovation and Partnerships, who represented the Vice Chancellor Prof. Barnabas Nawangwe at the event, highlighted the critical role of bacteriophage research in addressing the global threat of antimicrobial resistance (AMR). He explained how the misuse and overuse of antibiotics in human health, agriculture, and aquaculture have accelerated the emergence of drug-resistant bacterial strains, rendering standard treatments ineffective. Citing statistics from the World Health Organization, he pointed out that AMR claims over 1.3 million lives annually, a number expected to rise without urgent action. He lamented the stagnation of new antibiotic development due to high research costs and rapid bacterial resistance, making bacteriophage therapy a powerful and promising alternative.
A Section of the stakeholders that participated in the engagement.
Prof. Wamala expressed Makerere University’s commitment to advancing research that addresses critical societal challenges, aligning with its mission of generating transformative knowledge and fostering sustainable development. He emphasized Uganda’s potential to lead in bacteriophage research, driven by multi-disciplinary partnerships and capacity building. He also highlighted ongoing studies into aquaculture-specific bacteriophages at CoVAB as an example of how phage technology can revolutionize sectors like agriculture while addressing AMR. Through such efforts, the university aims to position Uganda as a global leader in innovative solutions to combat antimicrobial resistance and enhance public health.
Dr. Jesca Nakavuma, from the College of Veterinary Medicine, Animal Resources, and Biosecurity.
Dr. Jesca Nakavuma, widely regarded as the mother of phages in Uganda, delivered a compelling presentation at the Symposium, where she detailed the impressive progress of phage research in Uganda since its inception in 2017. She highlighted Makerere University’s pioneering efforts, starting with a cohort of five undergraduate students, which have since expanded into groundbreaking research addressing challenges in agriculture, clinical health, food safety, and environmental safety. Key achievements include advancements in E. coli and Salmonella detection, tackling avian colibacillosis, and innovations in decontamination methods, underscoring the transformative potential of phage technology in combating antimicrobial resistance and enhancing public health.
The University leadership included Prof. Robert Wamala (R) and Assoc. Prof. James Acai Okwee (C), Deputy Principal CoVAB.
The symposium honored collaborative efforts, including the establishment and accomplishments of Phage Team Uganda, which developed a repository of 125 characterized phage isolates and trained over 20 PhDs, MScs, and BSc students. Partnerships with international organizations such as IDRC InnoVet AMR and AU Safe Fish have significantly contributed to advancements in antimicrobial resistance and aquaculture.
The participants were actively involved in the discussions.
Despite these achievements, Dr. Nakavuma noted challenges such as insufficient facilities for large-scale phage production, regulatory limitations, and financial constraints. She affirmed that despite the challenges, the team remained ambitious, envisioning the creation of a fully equipped Phage Research and Development Center, the commercialization of phage products, and the establishment of policy frameworks to support the use of phages in Uganda.
The Deputy Principal of CoVAB, Prof. James Acai Okwee, warmly welcomed the partners to the conference and acknowledged their invaluable contributions to the college’s research efforts. He emphasized the importance of collaboration in driving innovation and achieving impactful results, highlighting the pivotal role that partnerships play in fostering academic and scientific growth. Prof. Okwee’s remarks set an encouraging tone for the conference, reinforcing the college’s commitment to advancing research initiatives and creating opportunities for shared learning and development.
Part of the audience at the symposium.
The event that attracted the participation of various stakeholders including academia, civil society, and policy makers, concluded with acknowledgments of the efforts of Phage Team Uganda, collaborators, and funders, setting the stage for an exciting future in Uganda’s journey to combat antimicrobial resistance and ensure food and environmental safety.
The Makerere University Biomedical Laboratory Technology Students Association (MUBLISA) recently organized a transformative mentorship meeting at the College of Veterinary Medicine, Animal Resources, and Biosecurity (CoVAB) at Makerere University, inspiring students to excel in biomedical laboratory technology. The mentorship session aimed to bridge the gap between academic knowledge and real-world application while promoting diversity, inclusion, and professional development.
Two accomplished alumni were present at the event and they shared invaluable insights into thriving in the professional landscape beyond academic lectures. Their stories resonated with attendees, providing practical advice and motivation to navigate the challenges of building successful careers. It was also attended by the Dean, of the School of Biosecurity, Biotechnology and Laboratory Sciences (SBLS), Dr. Claire M. Mugasa.
Dr. Kiyemba Stephen Kaggwa, the distinguished director of Ebenezer Laboratories, delivered an uplifting keynote address that left a lasting impression on students and professionals alike. Known for his groundbreaking contributions to biomedical laboratory technology, Dr. Kaggwa encouraged aspiring professionals to explore their field’s untapped potential and underscored the transformative role of mentorship in fostering personal and professional growth.
Dr. Kaggwa (Left), flanked by the Dean SBLS. Dr. Claire M. Mugasa.
Dr. Kaggwa, who leads Ebenezer Laboratories, an institution celebrated for its dedication to accurate diagnostics and advancing medical science in the region as a prominent clinical laboratory based in Kampala, further demonstrated his commitment to healthcare innovation and patient-centered care. The inspiring event served as a powerful reminder of the importance of leadership, mentorship, and innovation in shaping the next generation of professionals. It left students motivated to not only succeed but also to make a meaningful impact in their chosen fields.
Ms. Eunice Ainomugisha, the Vice Chair of the Allied Health Professionals Council addressed the BLT students.
The other speaker, Ms. Eunice Ainomugisha, the Vice Chair of the Allied Health Professionals Council where she represents the medical laboratory reiterated the value of building meaningful relationships and staying organized to seize opportunities. Ainomugisha who illustrated her points by using her own experience as a struggling young girl to seize the available opportunities in the field, encourages the students to dream big and seek out the best for themselves despite the circumstances.
Dr. Gabriel Tumwine, representing the head of the Biomedical Laboratory Technology Department, Dr. Kato Drago highlighted the need for mentorship alongside academic training. He commended MUBLISA for taking the lead in empowering students to develop connections and skills essential for their careers. Students were inspired by the event’s message of perseverance, hard work, and the “power of right connections.” This pioneering mentorship program set the stage for many more initiatives aimed at equipping biomedical laboratory technology students with tools for success in academia, research, and industry.
Dr. Gabriel Tumwine explained the importance of having mentors as students.
The mentorship meeting not only celebrated the achievements of the department but also served as a powerful reminder of the impact Makerere University‘s graduates continue to make in advancing health and scientific research.