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Veterinary & Biosecurity

Rabies Exposure Assessment & Contact Tracing App (REACT), another milestone in rabies surveillance in Uganda; A status update of the implementation of the eRabies project

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The eRabies project was launched in March 2023 at the Centre for Biosecurity and Global Health, Makerere University. To date, a lot has been realized through several stakeholders working together toward the global goal of eliminating dog-mediated rabies by 2030.

This project is a collaboration between Makerere University‘s College of Veterinary Medicine, Animal Resources and Biosecurity, and the Universities of Zurich and Bern, and funded by the Swiss National Science Foundation.

The four-year intervention through its seven work streams was initially implemented in the Districts of Kampala, Soroti, and Kyegegwa and has stretched to include Arua, courtesy of other stakeholders including the NGO Mission Rabies that came on board along the way.

By the time of the launch, the stakeholders involved included Makerere University College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), School of Public Health, College of Health Sciences, and the Infectious Diseases Institute (IDI), working in collaboration with the Universities of Bern and Zurich from Switzerland.

Prof. Sonja Hartnack from the University of Zurich spoke at the project launch at CoVAB. College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala Uganda and the Universities of Zurich and Bern, funded by the Swiss National Science Foundation, eRabies project, Rabies Exposure Assessment & Contact Tracing (REACT) App Pilot, 2nd - 3rd May 2024, Arua District, Uganda, East Africa.
Prof. Sonja Hartnack from the University of Zurich spoke at the project launch at CoVAB.

According to Prof. Sonja Hartnack, from the Vetsuisse Faculty, University of Zurich, the project has addressed several work packages in addition to the initial Surveillance systems and integrated dog bite case management. During a project brief with staff at the College of Veterinary Medicine, Animal Resources and Biosecurity recently, it was revealed that the four-year project has made great strides as evidenced by the outcomes of several workshops conducted.

Prof. Sonja Hartnack said further to efforts towards the electronic surveillance of dog bites which started with the launch workshop held in August 2023, another workshop was held in Arua on May 2-3, 2024 for the pilot of the REACT App, a tool created by CDC and Mission Rabies for Integrated Bite Case Management. REACT is the abbreviation for Rabies Exposure Assessment & Contact Tracing App. The workshop brought together stakeholders from both animal and human health sectors, drawn from the district to national levels.  During the workshop, there were in-depth discussions regarding the current rabies surveillance system across the four target districts in Uganda.  The meeting explored how the REACT App can enhance the integrated bite case management system and data management process in rabies.

Participants at the e-rabies surveillance workshop in Arua, May 2nd -3rd, 2024. (Courtesy photo) College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala Uganda and the Universities of Zurich and Bern, funded by the Swiss National Science Foundation, eRabies project, Rabies Exposure Assessment & Contact Tracing (REACT) App Pilot, 2nd - 3rd May 2024, Arua District, Uganda, East Africa.
Participants at the e-rabies surveillance workshop in Arua, May 2nd -3rd, 2024. (Courtesy photo)

Prof. Sonja Hartnack who was in the company of CoVAB’s Terrence Odoch and Prof. Clovice Kankya said the pilot was to focus on integrated bite case management. This is the very first part which is still ongoing and there were concrete follow-up plans to try and foster this integrated bite case management. The Data to be collected was from both the point of view of the human-dog bite victim, but also captures whether the dog was vaccinated, provoked, killed, and a sample taken, all adding up in a true multi-sectoral and one health approach, she observed.

For the second work package which is about community engagement for rabies vaccination and dog bite prevention, she said there was already one Master’s student thesis submitted following both a qualitative and quantitative approach, and currently the student was finalizing the manuscript. Similarly, a paper on the Barriers to Vaccination at the community level and responsible dog ownership on the perceptions of dog owners was also written.

Participants discussed strategies for effective implementation of the intervention. College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala Uganda and the Universities of Zurich and Bern, funded by the Swiss National Science Foundation, eRabies project, Rabies Exposure Assessment & Contact Tracing (REACT) App Pilot, 2nd - 3rd May 2024, Arua District, Uganda, East Africa.
Participants discussed strategies for effective implementation of the intervention.

The other studies she said, focused on the identification of one strategy through a sensitization campaign.  This would include many respects including mobilizing dog owners to bring their dogs for mass vaccination on selected days and places. Such places like Schools, she said, would enable educating the children.  The other option would be conducting mass vaccination campaigns integrated with livestock activities whereby the communities will be asked to come with their dogs close to a point in the farm or to organize jointly with the human health activities.

Participants from the implementing districts of Kyegegwa, Soroti, and Kampala where some of the interventions are ongoing. College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala Uganda and the Universities of Zurich and Bern, funded by the Swiss National Science Foundation, eRabies project, Rabies Exposure Assessment & Contact Tracing (REACT) App Pilot, 2nd - 3rd May 2024, Arua District, Uganda, East Africa.
Participants from the implementing districts of Kyegegwa, Soroti, and Kampala where some of the interventions are ongoing.

Harriet Musinguzi

Veterinary & Biosecurity

Mak Hosts INSSPIRE Project Workshop on Enhancing Evidence-Based Education on Food Systems and Climate Change

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Written by Jacinta Nakaye

Kampala, Uganda – October 14, 2024 – Makerere University’s College of Veterinary Medicine, Animal Resources and Biosecurity (COVAB) is hosting a five-day Training of Trainers workshop for the Collaborative Online International Learning (COIL) model.  This is part of the Innovation for Sustainability and Societal relevance (INSSPIRE) project, which focuses on enhancing evidence-based education in food systems and climate change.

The workshop that brought together partners and stakeholders from various higher education institutions across Southern and Northern Africa to brainstorm innovative strategies for addressing these pressing global challenges.

During the opening session held at the Centre for Biosecurity and Global Health (CEBIGH) at CoVAB, stakeholders demonstrated their progress in implementing Real Life Learning Labs (RLLL), an experiential learning approach designed to foster interdisciplinary collaboration on real-world development projects. These labs aim to tackle relevant issues in agriculture, industry, and society by equipping students with practical skills and problem-solving capabilities.

Assoc. Prof.r Robert Wamala, Director of Research and Graduate Training represented the Vice Chancellor Prof. Barnabas Nawangwe at  the opening ceremony .

Associate Professor Robert Wamala, Makerere University’s Director of Research and Graduate Training delivered a keynote address on behalf of Vice Chancellor Makerere University Prof. Barnabas Nawangwe. He emphasized the severe impact of climate change on global food systems, particularly in vulnerable regions. “Climate change disrupts food systems globally, aggravating food security by impacting agricultural production through extreme weather events and shifting rainy seasons,” he stated. Prof. Wamala highlighted the need for transformative solutions that address the intertwined issues of food security and environmental degradation, which was on the areas to be addressed through the intervention.

The INSSPIRE project aims to stimulate innovative education and build inter-university capacity through international partnerships. By focusing on capacity building in higher education, the initiative supports staff development at participating universities in Kenya and Uganda thereby enhancing the delivery of educational modules on food systems and climate change.

Dr. Denyse Snelder, a senior advisor in Food and Nutrition Security and Sustainable Land & Water Management at the Centre for International Cooperation- Vrije Universiteit Amsterdam (CIS-VU) makes a presentation during the workshop.

 Dr. Kato Charles Drago from CoVAB who is the team lead for the INSSPIRE project at Makerere University, coordinated the workshop, which attracted  participation from institutions such as South Eastern Kenya University, the Institute for Innovation & Development of the University of Ljubljana, Mbarara University of Science and Technology, Maseno University, the University for Development Studies (UDS) in Tamale, Ghana, and the University of Energy and Natural Resources (UENR) in Sunyani, Ghana.

Prof. Frank Norbert Mwiine, the Principal of COVAB made his remarks and promised total support to the project.
Prof. Frank Norbert Mwiine, the Principal of COVAB made his remarks and promised total support to the project.

Prof. Frank Norbert Mwiine, the Principal of COVAB, in his address to the participants noted that Uganda’s economy largely depends on agriculture and the sector supports several families and employs a big part of the population both formally and informally including graduates from Makerere University across several disciplines. He said food systems in the country were rapidly evolving as a result of population demands amidst the increasing challenge of climate change. ‘We are glad that the INSSPIRE project plans to address this gap by strengthening food systems and adapting them to the challenges of climate change, he said.

Some of the participants in the workshop have a look at one of the posters spelling out activities of Real-Life Learning Labs

Prof. Mwiine appreciated the support that CoVAB will receive from the project in enriching curricula for two courses under the Bachelor of Animal Production Technology (BAP) by building the capacity of  staff  to deliver modules on food systems, which he said, would make the graduates competitive in the ever-changing job market. The training of staff in curriculum enrichment and new course delivery approaches like the Collaborative Online International Learning (COIL), and gamification will help improve teaching and aid student’s interest and understanding of agriculture-based courses. He observed. While addressing himself on the real life-learning labs pioneered by the INSSPIRE project, he said the model will facilitate students to acquire practical skills and hence enhance their relevance in the community as the students and staff support communities to identify real-life challenges and tackle them holistically. He reaffirmed the commitment of the college leadership in moving these innovations forward, as demonstrated and that the college was ready to engage further in resource mobilization drives to propel the innovations forward.

Sabina di Prima (right), a Sustainable Food Systems specialist and Manager of International Cooperation Projects at the Centre for International Cooperation- Vrije Universiteit Amsterdam (CIS-VU) leads a group of participants during an experiential demo

As the workshop unfolds over the coming days, participants will deliberate on innovative strategies to transform food systems and advance climate change education, underscoring the critical importance of multidisciplinary approaches in fostering sustainable development.

Harriet Musinguzi

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FPAIC calls for collective responsibility in resource allocation and utilization at CoVAB

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Mr. Bruce Kabaasa (Centre) addressed the meeting at CoVAB. Makerere University Finance Planning, Administration, and Investment Committee (FPAIC) of Council led by Mr. Bruce Kabaasa inspection visit to the College of Veterinary Medicine, Animal Resources, and Biosecurity (CoVAB), Makerere University, Kampala Uganda, East Africa.

Makerere University Finance Planning, Administration, and Investment Committee (FPAIC) led by Mr. Bruce Kabaasa conducted an inspection visit to the College of Veterinary Medicine, Animal Resources, and Biosecurity as part of their university-wide tour on August 27th, 2024. The interface was part of the evaluation of budget execution for the 2023/2024 financial year.

While at CoVAB, the committee interacted with the management and staff of the college led by the Principal, Prof. Frank Norbert Mwiine, including the Deans of the two Schools, Heads of Departments, Principal Investigators of several projects, at the meeting convened in the CEBIGH conference hall.

Mr. Bruce Kabaasa, who was in the company of the Deputy Vice Chancellor of Finance and Administration Prof. Henry Alinaitwe, and other members of the committee noted that the university was moving towards denying researchers grants that do not respond to the needs of the university or the college.  ‘Those running grants try to ensure the project activities have a relationship with the host discipline for instance by improving the lab equipment to be used in teaching and learning. The center cannot continue considering issues of sanitation yet we have some overheads accruing from some projects in the units, he said, adding that the colleges needed to operate as a human body, where what happens in one area is felt everywhere with the principal on top of the game, and involving all stakeholders who must take a keen interest in what is going on.

A section of CoVAB staff that attended the meeting. Makerere University Finance Planning, Administration, and Investment Committee (FPAIC) of Council led by Mr. Bruce Kabaasa inspection visit to the College of Veterinary Medicine, Animal Resources, and Biosecurity (CoVAB), Makerere University, Kampala Uganda, East Africa.
A section of CoVAB staff that attended the meeting.

The FPAIC’s visit to CoVAB was part of its broader mandate to ensure financial accountability, effective planning, and proper administration within the university. The discussions that followed a presentation on the budgetary allocations of the year 2023/24 focused on the utilization of funds across various schools and departments. The meeting also reviewed the performance report for the main and off-budget expenditures, highlighting key achievements, compliance issues, challenges, and proposed solutions.

Bruce Kabaasa in his remarks emphasized the need for the college to ensure that the Grants received follow the laid down structure of the institution to benefit the ongoing teaching and learning activities. He cautioned the college that funding next year was likely to be limited hence the need to use all available resources cautiously.  Regarding requests for extra staff, he said there was no way the university was going to give extra staff without establishing what those on the ground were doing. He informed the meeting that the university was to provide some funding to improve the state of labs CAES and CoVAB.

The team noted with concern that despite the resources allocated to improve E-learning in the university, this was not moving as expected. He urged the college to make its priorities including IT-related needs known to facilitate timely and adequate planning. ‘We are here to make sure that you demand what you need, and we want everybody to play their roles, he said while emphasizing the need for teamwork in the college.  He further explained that the uptake of MakRIF funds was henceforth going to be based on the relationship between the grant received and the unit outputs like teaching and learning.

(R-L) The Principal Prof Frank Norbert Mwiine, Deputy Principal, Dr. James Acai-Okwee, Dean SVA, Prof. Robert Tweyongyere, Procurement officer, and other staff attended the meeting. Makerere University Finance Planning, Administration, and Investment Committee (FPAIC) of Council led by Mr. Bruce Kabaasa inspection visit to the College of Veterinary Medicine, Animal Resources, and Biosecurity (CoVAB), Makerere University, Kampala Uganda, East Africa.
(R-L) The Principal Prof Frank Norbert Mwiine, Deputy Principal, Dr. James Acai-Okwee, Dean SVA, Prof. Robert Tweyongyere, Procurement officer, and other staff attended the meeting.

The Principal CoVAB Prof. Frank Norbert Mwiine pointed out several areas that needed to be addressed including the road accessing the Centre for Biosecurity and Global Health, the training centers at Buyana and Nakyesasa that needed to be invigorated, as well as transport challenges to enable students to go to the field for practical exposures in the field.

FPAIC mandate includes making reviews and approving proposed budget estimates from cost centers for council approval, overseeing the university’s banking and investment operations, and monitoring all expenditures under approved annual estimates. It also reviews requests for expenditures beyond approved estimates, makes recommendations, and prepares and submits the Development plans to the council.

The other role played by FPAIC is making proposals for fees and other rates to the Council, monitoring approved development programs to ensure they meet the university’s objectives, as well as maintaining an accurate, comprehensive inventory of university property. The committee also keeps records of the university’s staff establishments, conducts annual reviews of staff establishments, and makes recommendations for changes.

FPAIC members and other staff that attended the meeting. Makerere University Finance Planning, Administration, and Investment Committee (FPAIC) of Council led by Mr. Bruce Kabaasa inspection visit to the College of Veterinary Medicine, Animal Resources, and Biosecurity (CoVAB), Makerere University, Kampala Uganda, East Africa.
FPAIC members and other staff that attended the meeting.

Harriet Musinguzi

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Mak and UVRI Pilot Cyberbiosecurity Project to Safeguard Laboratory Facilities

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A group photo of participants during the Cyberbiosecurity Workshop on 16th August, 2024 at the Centre for Biosecurity and Global Health, CoVAB, Makerere University. Makerere University and Uganda Virus Research Institute Pilot Cyberbiosecurity Project to Safeguard Laboratory Facilities, Workshop, 16th August 2024, Centre for Biosecurity and Global Health, Kampala Uganda, East Africa.

By Joseph Odoi

A consortium of researchers from Makerere University‘s College of Veterinary Medicine, Animal Resources, and Biosecurity (COVAB) and the Uganda Virus Research Institute (UVRI), with support from CRDF Global have piloted a cyberbiosecurity project to address the growing threat of cyberattacks on laboratories handling high-risk biological materials.

As per  the International Federation of Biosafety Associations (IFBA), CyberBiosecurity is the “safeguarding and mitigation of misuse, exploitation, damage to or disruption of valuable information, data, databases, equipment, and facilities at the interface of the biological laboratory, related life sciences facilities, and digital worlds.”

The project, titled “Establishment of Cyber Biosecurity Inventory and Procedures for Effective Safety and Administrative Controls for COVAB and UVRI Laboratories in Uganda,” is led by Associate Professor Lawrence Mugisha from COVAB, Makerere University, and Dr. Stephen Balinandi from UVRI.

While hosting the workshop on August 16, 2024  at the  Centre for Biosecurity and Global Health, Makerere University ,  Professor Mugisha  in a special way welcomed the participants  to the workshop. He noted that; Cyber threats and attacks have become a  serious threat to many establishments including (government institutions, business enterprises and other critical facilities like financial and health facilities) across the global disrupting services and causing serious financial losses in addition to individual and institutional safety.

Associate Professor Lawrence Mugisha giving an overview of the project. Makerere University and Uganda Virus Research Institute Pilot Cyberbiosecurity Project to Safeguard Laboratory Facilities, Workshop, 16th August 2024, Centre for Biosecurity and Global Health, Kampala Uganda, East Africa.
Associate Professor Lawrence Mugisha giving an overview of the project.

‘’ More recently these attacks have extended and targeted laboratories handling biological materials including high risk and highly pathogenic organisms like anthrax, ebola, SARS-CoV2 viruses with potential for bioterrorism.

To contribute to data driven interventions  aimed at securing and protecting laboratory facilities handling high consequence/risk pathogens from cyber-attacks and the need for cyberbiosecurity,  Makerere University led by College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB) in collaboration with Uganda Virus Research Institute (UVRI) is implementing the first pilot project in Uganda on Cyberbiosecurity.

This collaborative project  is aimed at  mapping and identifying  potential cybersecurity threats to the biological laboratories at Makerere University and UVRI by conducting a thorough information and communication Technology (ICT) risk assessments.  The project will then develop comprehensive Cybersecurity Standard Operating Procedures, guidelines and manuals with a goal of establishing  Cyberbiosecurity Policy.  Furthermore, the project is aimed at  creating awareness about  cyber threats, cyber biosecurity, biosafety and biosecurity among staff, scientists/researchers and management at the two institutions to promote Cyber security best practices’’ explained Prof. Mugisha

In his opening remarks, CoVAB Principal Prof. Frank Norbert Mwiine emphasized the reality of cyberbiosecurity threats, sharing that he himself has been a victim of a cybersecurity breach involving his atm. He urged the team to consider developing training projects focused on cyberbiosecurity and to build a strong cybersecurity research team within CoVAB and UVRI. Prof. Mwiine also called on the team to actively seek research opportunities around cyberbiosecurity adding that   CoVAB is open to collaborations.

CoVAB Principal Prof. Frank Norbert Mwiine sharing insights on cyberbiosecurity  at the Workshop. Makerere University and Uganda Virus Research Institute Pilot Cyberbiosecurity Project to Safeguard Laboratory Facilities, Workshop, 16th August 2024, Centre for Biosecurity and Global Health, Kampala Uganda, East Africa.
CoVAB Principal Prof. Frank Norbert Mwiine sharing insights on cyberbiosecurity  at the Workshop.

Furthermore, Prof. Mwiine expressed his gratitude to Prof.  Mugisha for his tireless efforts in coordination and leading activities and projects  advancing ethics, bioethics and biosafety in Uganda, noting that Prof. Mugisha played a key role in establishing Institutional Animal Care and Use Committee (IACUC) and Institutional Biosafety Committee (IBC) at Makerere University. Prof. Mwiine also reiterated Makerere University’s commitment to cyberbiosecurity and biosecurity, highlighting the ongoing research collaboration between CoVAB and UVRI.

In her presentation centered around Dual-Use Research of Concern (DURC), Sandra Matinyi, Co-founder and Executive Director of Nuo Bioscience, shared critical insights on the global guidance framework for the responsible use of life sciences. This framework, published by the World Health Organization (WHO) in 2022, focuses on mitigating biorisks and governing dual-use research.

Sandra Matinyi, Co-founder and Executive Director of Nuo Bioscience, sharing critical insights on the global guidance framework for the responsible use of life sciences. Makerere University and Uganda Virus Research Institute Pilot Cyberbiosecurity Project to Safeguard Laboratory Facilities, Workshop, 16th August 2024, Centre for Biosecurity and Global Health, Kampala Uganda, East Africa.
Sandra Matinyi, Co-founder and Executive Director of Nuo Bioscience, sharing critical insights on the global guidance framework for the responsible use of life sciences.

‘’With the emergence of new technologies and rapid advancements in life sciences research, there was previously no global guidance for identifying or mitigating risks related to dual-use research of concern until the WHO introduced this framework in 2022.’’

She noted that Uganda, while still lacking a specific policy on DURC, is among the first countries to pilot the introduction of the WHO framework. This positions Uganda at the forefront of adopting international standards for biosecurity, which is essential given the global nature of these concerns.

“As a country, Uganda has not yet developed a specific policy, but we are among the first to pilot the introduction of this framework.

‘’Mitigating biorisks and governing dual use research is a global issue as we live in a global village. Its a shared responsibility and everyone has a role to play including scientists, researchers, the public among others. The framework is based on a one health approach and it does not assume a one fits it all approach. We ought to customize framework to the Ugandan context.’’” added.

A Participant making a submission at the workshop. Makerere University and Uganda Virus Research Institute Pilot Cyberbiosecurity Project to Safeguard Laboratory Facilities, Workshop, 16th August 2024, Centre for Biosecurity and Global Health, Kampala Uganda, East Africa.
A Participant making a submission at the workshop.

In her presentation, Dr. Monica Namayanja highlighted the critical importance of establishing a Bio-Risk Management Committee, the role of dedicated biosafety officers, and the need for specialized laboratory managers. She emphasized that the involvement of top management is crucial for effective bio-risk management, noting that continuous improvement in this area is essential for maintaining best practices.

During the workshop, participants and project team shared   lessons and facility based best practices desired for cybersecurity focusing on pertinent aspects of safeguarding digital and biological infrastructures.

The presentations also explored emerging topics in biosecurity including Dual Research (DUR), Dual Research of Concern (DURC) and Know Your Collaborator |(KYC)

The project, which started in April 2024 and is set to conclude in September 2024, was made possible with support from CRDF Global (Strengthening Individuals | Building Relationships | Improving Our World).

For More Information, please contact project Principal Investigator, Prof. Lawrence Mugisha, Tel.+256772566551, email: mugishalaw@gmail.com/lawrence.mugisha@mak.ac.ug

Mak Editor

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