Uganda’s latest national HIV survey reveals lower viral suppression among adolescents and young adults living with HIV than among older adults, even as the country records substantial improvements in controlling the virus. The findings come from Uganda Population-Based HIV Impact Assessment (UPHIA 2025), a national household survey examining HIV prevalence and whether people living with the virus know their status, receive treatment, and achieve viral suppression.

Releasing the preliminary UPHIA 2025 findings at the Uganda Media Centre on 1 October 2026, Minister of Health Hon. Dr. Chris Baryomunsi called for earlier prevention and testing, particularly among adolescent girls and young women, alongside support for treatment adherence. “We must reach out to the young people, ensure that they have information, they test, take treatment, and adhere to the treatment guidance,” he urged.

Hon. Baryomunsi recalled how fear had discouraged testing during his university years: “I remember when we were at university, we went for testing at the university hospital. We sat there for three hours. Some of us left without even testing because it was scary.” Today, he explained, “even if you test HIV positive, you can be initiated on treatment, and you live normally like the rest of those who don’t have HIV.”

UPHIA 2025 was locally led under the Ministry of Health’s overall leadership, with Makerere University School of Public Health serving as the prime implementer, a role ICAP at Columbia University held in the previous two surveys. The Uganda Bureau of Statistics led sampling, while the Uganda Virus Research Institute and National Health Laboratory and Diagnostic Services led laboratory operations. Regional referral hospitals and local governments supported implementation, and the U.S. government provided US$10 million through PEPFAR, along with technical assistance from the U.S. CDC.

UPHIA collected data from July to September 2025 among people aged 15 and above, including those outside routine treatment services. Of 6,283 eligible households, 94.4% completed interviews. Researchers interviewed 13,801 people and tested 13,477 for HIV.

Testing followed Uganda’s national algorithm, with laboratory confirmation of positive samples, viral-load measurement, and checks for antiretroviral medicines to establish treatment use. Researchers weighted the estimates to account for the sampling design. Participants received counselling and results, and those who tested positive were referred for treatment.

Hon. Baryomunsi thanked participants and their families for welcoming survey staff and contributing their time, information and samples, without which the national evidence would not have been available.

National progress and the youth gap

The survey estimated HIV prevalence, which means the proportion of people living with HIV, at 5.9% among those aged 15 and above, corresponding to about 1.496 million people in this age group nationwide. Prevalence was 7.3% among women and 4.1% among men, ranging from 1.3% in Karamoja to 8% in the South Western region.

Among people aged 15 and above living with HIV, 86% had achieved viral suppression, meaning a low amount of HIV in the blood, measured in UPHIA as fewer than 1,000 copies per millilitre. Suppression stood at 69.3% among adolescents and young adults aged 15–24 living with HIV, compared with 89.9% among those aged 50 and above. These estimates cover people living with HIV regardless of whether they know their status or receive treatment.

HIV prevalence among people aged 15–24 was 1.5%, including 2% among young women and 1% among young men. Among young women, prevalence was 1.3% at ages 15–19 and 2.8% at ages 20–24. These differences support attention to earlier prevention and testing, although they do not establish when infections occurred.

The highest prevalence estimates occurred among middle-aged adults: 15.7% among women aged 40–44 and 11.7% among men aged 45–49. Lower suppression among young people therefore requires attention alongside the higher HIV prevalence among middle-aged adults. Comparing the same age group across both surveys, viral suppression among people aged 15–64 increased from 74.9% in 2020–21 to 86.1% in 2025, while HIV prevalence remained at 5.9%.

Diagnosis and the path to 2030

The treatment results identify diagnosis as the main national gap. Among people aged 15 and above living with HIV, 85.3% knew their status. Of those aware, 99.1% were receiving treatment; among those receiving treatment, 96.5% had achieved suppression.

The 95-95-95 targets aimed for 95% of people living with HIV to know their status, 95% of those diagnosed to receive treatment, and 95% of those receiving treatment to achieve viral suppression by 2025. Among people aged 15 and above, Uganda exceeded the treatment and suppression targets, while diagnosis remained below target. UNAIDS’s Global AIDS Strategy 2026–2031 retains these targets towards ending AIDS as a public health threat by 2030.

According to WHO, viral suppression protects health and helps prevent HIV transmission. Uncontrolled HIV weakens the immune system, increasing the risk of serious illness. With continued treatment as prescribed, sexual transmission risk is negligible when HIV remains suppressed but detectable, and zero when undetectable. The Uganda AIDS Commission estimated over 34,000 new HIV infections in 2025, underscoring the importance of early diagnosis, timely treatment, and sustained suppression alongside other prevention measures.

The demographic stakes are substantial. People aged 15–24 constituted 21.2% of Uganda’s population in the 2024 census. The country’s Fourth National Development Plan, covering 2025–2030, prioritises a healthy, knowledgeable, skilled and productive population and reducing HIV through primary health care. Protecting young people’s health, therefore, supports their participation in education, work, and national development; UPHIA helps identify where services need greater attention.

Turning evidence into action

The study’s conclusions identify three priorities: sustain treatment outcomes, find people unaware of their status, and improve suppression among younger people. Permanent Secretary Dr. Diana Atwine connected the findings to the Ministry’s planning.

“We do believe that these results are a true reflection of what is happening in our country as far as the HIV status is concerned, and we do believe that it will give us a very clear direction and the roadmap that we are going to take in the next five years to target and to get our targets achieved.”

Acting on these priorities requires funding for services and research. Hon. Baryomunsi outlined plans to target resources where needs are greatest, strengthen district services and align partner support with government priorities. Responding to journalists’ questions, he noted the government’s intention to increase domestic funding for the HIV response, including research.

“The HIV/AIDS response, including research and surveys such as this one, has largely been funded by partners in the past. The government of Uganda is committed to allocating more resources from our domestic budget to support the response and research,” he noted.

For the first time in the UPHIA series, the survey assessed selected noncommunicable disease indicators among people aged 15 and above: 15.5% had elevated blood pressure, 24.8% were overweight or obese, and 0.9% had raised random blood glucose. These screening findings align with the Ministry’s integration agenda and Hon. Baryomunsi’s call to bring HIV and chronic care services together to address people’s wider health needs.

Speaking at the release of the preliminary results, U.S. Embassy Chargé d’Affaires Mikael (Mika) Cleverley described UPHIA 2025 as the first Population-Based HIV Impact Assessment worldwide fully led and implemented by the country itself.

“The study was led by Ugandan scientists, Ugandan managers, Ugandan public servants, Ugandan field teams, from design to data collection to analysis. And this is what two decades of focused strategic U.S. foreign investments in the public health sector was meant to produce, is to reinforce Ugandan leadership and Ugandan-led efforts.”

At the survey launch on 29 May 2025, MakSPH Dean Prof. Rhoda Wanyenze highlighted the partnership’s contribution: “The partnership between Makerere University and CDC has not only helped build national capacity in surveillance and epidemiology, but has also strengthened our ability to lead high-quality, large-scale national surveys.”

The Dean added: “After two decades of joint work, we are proud that UPHIA is now a fully Ugandan-led effort. This is critical to the sustainability of the skills and knowledge generation to inform our local response.”

UPHIA 2025 shows how far Uganda’s HIV response has advanced and where gaps remain. As the country works towards ending AIDS as a public health threat by 2030, reaching young people with testing, treatment, and continued care will be essential to extending those gains.

Read the full UPHIA 2025 summary results here:

UPHIA 2025 SUMMARY SHEET

The Directorate of Graduate Training (DGT) invites applications from eligible PhD candidates at Makerere University for the PhD Completion Grant Programme for the Fiscal Year 2026/2027.

This grant is specifically designed to support doctoral candidates who are at an advanced stage of their research and are on the verge of finalising their thesis/dissertation, but who do not have an alternative source of funding for the requested period.

Please see download below for the detailed call.

Deadline: Friday 16^th October 2026, 5:00PM EAT

For communities living along Uganda’s lakes and rivers, water hyacinth is more than an invasive weed. Its rapid spread can choke waterways, disrupt fishing and transportation, restrict access to water and interfere with livelihoods and essential community services.

But what has for years been viewed primarily as an environmental menace could also become a source of economic opportunity.

Turning an environmental challenge into an opportunity

Researchers at Makerere University, with support from the Government of Uganda through the Makerere University Research and Innovations Fund (MakRIF), have demonstrated how water hyacinth can be harvested and transformed into useful, value-added products through a small-scale community bio-refining approach.

Their project, titled “From World’s Worst Water Weed to Worth: Small-scale Community Bio-refining of Water Hyacinth to Produce Value-added Commercially Valuable Products,” sought to shift the focus from simply removing and disposing of the invasive plant to exploring opportunities for value addition, innovation and enterprise.

Led by Dr. Alice Nabatanzi from the Department of Plant Sciences, Microbiology and Biotechnology at the College of Natural Sciences (CoNAS), Makerere University, the research was inspired by the experiences of communities affected by water hyacinth, including residents of Katosi Ward in Mukono District, where the weed has had significant socio-ecological impacts.

According to a community assessment conducted as part of the research, 68.7% of the respondents reported extreme impacts on fishing, while 65.0% reported extreme impacts on water transport.

During community engagements, residents described how the proliferation of water hyacinth had blocked waterways, disrupted fishing and transportation, affected access to water and created significant challenges for household livelihoods. In some instances, obstructed waterways affected children’s access to essential services.

These experiences provided an important starting point for the research team.

Through different processing methods, the team successfully developed three products from the harvested biomass: a bio-fertilizer, briquettes, and biodegradable sanitary pads.

Water hyacinth transformed into bio-fertilizer

One of the products developed by the researchers was a bio-fertilizer made from water hyacinth biomass.

The process began with harvesting the weed from affected water bodies and shredding the biomass to facilitate processing. The researchers explored biological processing approaches, including composting, vermicomposting and anaerobic digestion, to break down the plant material and release its organic matter and nutrients.

Following processing and curing, the resulting material was developed into an organic soil amendment, providing a productive use for harvested water hyacinth while returning organic matter and nutrients to the soil.

 Briquettes offer an alternative solid fuel

The project team also developed briquettes from water hyacinth biomass, demonstrating its potential as an alternative solid fuel.

The innovation could, with further research, development and appropriate commercialization pathways, contribute to community-based enterprises.

 From water hyacinth fibre to biodegradable sanitary pads

Another distinctive innovation emerging from the research is a biodegradable sanitary pad.

To produce the absorbent material, researchers extracted cellulose-rich fibre from the petioles of water hyacinth and combined it with other locally available plant fibres, including banana fibre and papyrus.

The resulting plant-based material was incorporated into sanitary pads that were subsequently developed and tested to assess their performance as a menstrual hygiene product.

According to the research findings, the water-hyacinth-based pads demonstrated higher liquid absorption capacity and potential health and safety advantages compared with conventional pads. Their use of locally available plant fibres also offers potential to reduce production costs and improve accessibility.

Research generating scientific knowledge

In addition to developing value-added products, the project has generated scientific knowledge on the socio-ecological effects of water hyacinth on affected communities.

The research findings have been published in Scientific Reports, Springer Nature Journal, in a peer-reviewed paper by Nabatanzi, A., Nambejja, C. and Byarugaba, I. (2026) titled “Socio-ecological impacts of water hyacinth (Pontederia crassipes (Mart) Solm) on livelihoods in Katosi Ward, Uganda.”

The study provides evidence of the impacts of water hyacinth on livelihoods, while the wider project demonstrates how the same invasive resource can be investigated as a potential source of useful products.

Other research outputs: Production of personal care and wellness products from different plant materials

Beyond their work on value-added products from water hyacinth, Dr. Alice Nabatanzi and her research team are also translating scientific research into a growing range of locally developed skincare, personal care and wellness products under AURENE AURA, a Ugandan innovation emerging from the Makerere University Plant Sciences, Microbiology and Biotechnology (PMB) Product Development Hub.

Built around the integration of research, nature and innovation, AURENE AURA brings together botanical ingredients and formulation science to develop products designed for diverse skincare and personal wellness needs. The growing collection includes medicated acne-control bars, radiant and brightening soaps and lotions, hypoallergenic goat-milk cleansing bars, moisturizing shower gels, baby-care jelly, lip balms and lip gloss, liquid soaps and other personal-care formulations.

The portfolio also extends to fragrances and botanical perfume mists, herbal respiratory wellness products, and botanical teas and wellness blends, demonstrating the team’s efforts to explore the potential of locally sourced natural ingredients beyond conventional applications.

According to the team, the products are developed through a research-to-product process that involves identifying specific user needs, selecting appropriate botanical and active ingredients, formulation, testing, refinement and packaging. This approach seeks to combine the benefits of botanical ingredients with formulation science, product stability and user safety.

 Research dissemination workshop

Dr. Nabatanzi and her research team presented the findings and innovations to the Makerere University community and key stakeholders during a research dissemination workshop held on 22^nd September 2026 at the Department of Plant Sciences, Microbiology and Biotechnology.

The seminar provided a platform for the team to share the research outcomes, demonstrate the innovations and discuss pathways for translating the findings into practical solutions with environmental, social and economic value.

Remarks from the Chair, MakRIF

Representing the Chairperson of the Makerere University Research and Innovations Fund (MakRIF), Dr. Michael Owor commended the research team for moving beyond documenting the water hyacinth challenge to developing practical innovations with potential community and commercial applications.

He noted that the project exemplifies MakRIF’s mandate, established by the Government of Uganda to support research and innovation that responds to national development challenges.

 “This project exemplifies that mandate by moving beyond describing the problem of water hyacinth to developing practical solutions that communities, enterprises and public institutions can potentially adopt,” he said.

He, however, noted that research findings and prototypes do not automatically translate into sustainable impact, stressing the need for stronger collaboration amongst stakeholders to advance product validation, safety, quality, affordability, regulatory compliance, intellectual property protection and market access.

He urged stakeholders to use the workshop to agree on concrete pathways for advancing the innovations, including further testing, standards development, community-based production, manufacturing and distribution partnerships, and resource mobilisation for scale-up.

Regarding the biodegradable sanitary pads, Dr. Owor stressed the need for sustained engagement with women and girls, schools, health professionals and relevant regulatory institutions to ensure that the product is safe, acceptable, affordable and responsive to the users’ needs.

He further challenged the research team to develop a clear post-project action plan.

“Dissemination should not mark the end of the project; it should serve as a transition from research findings to adoption, enterprise development and demonstrable community impact,” he said.

On behalf of the MakRIF Grants Management Committee, Dr. Owor appreciated the Government of Uganda for its continued investment in research and innovation through the MakRIF, and acknowledged the University Management for providing an enabling environment for the research.

He also recognized the contribution of the participating communities and stakeholders whose knowledge and experiences informed the project.

CoNAS: Turning knowledge into solutions for society – Remarks by the College leaders

On behalf of the Principal of the College of Natural Sciences (CoNAS), the Deputy Principal, Prof. Godwin Kakuba, congratulated Dr. Nabatanzi and her team on undertaking impactful, transformative and accessible research that demonstrates how a persistent environmental challenge can be turned into an opportunity for innovation, livelihoods and sustainable development.

Referring to the priorities of Uganda’s National Development Plan IV (NDP IV), Prof. Kakuba emphasized the importance of harnessing the country’s innovation capacity to drive socio-economic transformation. “Such research demonstrates how university-generated knowledge can contribute to addressing real-world environmental and socio-economic challenges.”

He commended Dr. Nabatanzi for involving communities and students in the research process, noting that such engagements strengthen the relevance of university research while providing students with practical opportunities to apply scientific knowledge to challenges affecting society. He further underscored the need to strengthen industry-academia partnerships to facilitate the translation of research findings into products and technologies that can be adopted.

Prof. Kakuba also linked the initiative to the principles of competency-based learning, noting that practical, problem-solving research equips students with skills beyond the classroom and prepares them to contribute meaningfully to national development.

He urged Dr. Nabatanzi and the research team to widely disseminate their findings to increase awareness, uptake and potential commercialisation of the innovations. He also called for increased support to enable the project to progress beyond research and product development towards further validation, refinement, scaling and potential adoption by communities and industry.

 The Head of the Department of Plant Sciences, Microbiology and Biotechnology at CoNAS, Dr. Jamilu Ssenku, equally commended Dr. Nabatanzi and her team for undertaking impactful research that demonstrates the potential of science to address pressing environmental and socio-economic challenges. He noted that the project contributes to the department’s growing body of impactful research, which continues to generate practical solutions and innovations with relevance to communities, industry and national development.

MUTIC support

The Acting Manager of the Makerere University Technology and Innovation Centre (MUTIC), Prof. Michael Lubwama, commended the research team for its innovative approach to research and effective dissemination of the findings, noting that the project provides a valuable model that could be benchmarked by other research projects. He appreciated the contributions of the stakeholders, particularly the local communities whose participation was central to the success of the project. Prof. Lubwama further pledged MUTIC’s support in advancing the innovations towards product development, commercialization and wider community impact.

Innovation, commercialization and intellectual property

Ms. Esther Kabinga from the Makerere University Intellectual Property Management Office congratulated Dr. Nabatanzi and her team on the achievement and urged them to prioritise intellectual property protection as they advance the innovations towards wider use and commercialisation. She highlighted the need to formally register the innovations to safeguard them against unauthorised use, imitation and misappropriation, and pledged support in securing the necessary intellectual property rights.

Inspiring young women and advancing menstrual dignity

The Guild President of Makerere University, H.E. Gracious Kadondi, represented by the Guild Minister for Academic Affairs, Ms. Kalazani Neena Elsie, equally applauded Dr. Alice Nabatanzi and her research team for the achievements.

She particularly commended the development of biodegradable sanitary pads, noting that the innovation could help promote menstrual dignity among women and girls, especially those from economically disadvantaged backgrounds.

Ms. Kalazani also described Dr. Nabatanzi’s achievement as an important source of inspiration for young women and students pursuing science and research. She called for greater involvement of students and young people in research and innovation, noting that such opportunities can nurture the next generation of scientists and innovators capable of developing solutions to challenges affecting their communities.

Communities at the centre of research impact

On behalf of the Najjembe community in Buikwe District, Ms. Nabukeera Sylvia expressed gratitude to Dr. Alice Nabatanzi, MakRIF, and the wider University community for the continued support extended to local communities through the Alice Mabira Foundation (AMAF) and other research initiatives undertaken in the area.

Ms. Nabukeera said the community had greatly benefited from Dr. Nabatanzi’s work and the support provided through the Alice Mabira Foundation, which she established to empower households to develop home-based enterprises and cottage industries. Through the Foundation, community members have gained practical skills in baking, processing food and medicinal products, and preserving and sustainably utilising important tree species.

She noted that these initiatives have enabled community members to turn knowledge and locally available resources into livelihood opportunities and solutions to everyday challenges, demonstrating the value of research that responds directly to community needs. She expressed gratitude to the researchers and partners for their continued engagement with the Najjembe Community and called for sustained collaboration to ensure that the innovations generated through university research continue to reach communities and create tangible social and economic benefits.

Future prospects

The research has laid the groundwork for transforming water hyacinth from an environmental challenge into a potential source of community enterprise and sustainable livelihoods through bio-refineries and circular bio-economies.

Moving the innovations from research to wider application will require collaboration among researchers, communities, government, industry and other stakeholders to refine the technologies, assess production and market opportunities, strengthen quality standards and establish pathways for scale-up and commercialisation.

Beyond the three products already developed, the research also opens opportunities for exploring additional value chains, including animal feed, crafts and other potentially marketable products, subject to further research to establish their safety, technical feasibility and economic viability.

If successfully scaled, the innovations could create new opportunities for employment, income generation and community enterprise, while contributing to the sustainable management of water hyacinth and the restoration of affected waterways.

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